Serum concentration of selected angiogenesis-related molecules differs among molecular subtypes, body mass index and menopausal status in breast cancer patients
Background: Angiogenesis is a hallmark of breast cancer (BC) and is mediated by the vascular endothelial growth factor (VEGF) signaling axis. It is regulated by different proangiogenic factors, including platelet-derived growth factor-CC (PDGF-CC) and heparin-binding EGF-like growth factor (HB-EGF),...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 July 2022
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| In: |
Journal of Clinical Medicine
Year: 2022, Jahrgang: 11, Heft: 14, Pages: 1-13 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm11144079 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm11144079 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/11/14/4079 
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| Verfasserangaben: | Dimitrios Balalis, Dimitrios Tsakogiannis, Eleni Kalogera, Stefania Kokkali, Elli Tripodaki, Alexandros Ardavanis, Dimitrios Manatakis, Dionysios Dimas, Nektarios Koufopoulos, Florentia Fostira, Dimitrios Korkolis, Ioannis Misitzis, Nikolaos Vassos, Chara Spiliopoulou, Dimitrios Vlachodimitropoulos, Garyfalia Bletsa and Nikolaos Arkadopoulos |
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| 245 | 1 | 0 | |a Serum concentration of selected angiogenesis-related molecules differs among molecular subtypes, body mass index and menopausal status in breast cancer patients |c Dimitrios Balalis, Dimitrios Tsakogiannis, Eleni Kalogera, Stefania Kokkali, Elli Tripodaki, Alexandros Ardavanis, Dimitrios Manatakis, Dionysios Dimas, Nektarios Koufopoulos, Florentia Fostira, Dimitrios Korkolis, Ioannis Misitzis, Nikolaos Vassos, Chara Spiliopoulou, Dimitrios Vlachodimitropoulos, Garyfalia Bletsa and Nikolaos Arkadopoulos |
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| 520 | |a Background: Angiogenesis is a hallmark of breast cancer (BC) and is mediated by the vascular endothelial growth factor (VEGF) signaling axis. It is regulated by different proangiogenic factors, including platelet-derived growth factor-CC (PDGF-CC) and heparin-binding EGF-like growth factor (HB-EGF), as well as co-receptors, such as neuropilin-1, which could have prognostic implications in BC patients. Patients and methods: We assessed the serum levels of VEGF, HB-EGF, PDGF-CC and neuropilin-1 in 205 patients with early BC (invasive, n = 187; in situ, n = 18) and in 31 healthy donors (HD) and investigated the potential associations with clinical and histopathological parameters. Results: VEGF serum levels were significantly higher in patients with invasive versus ductal carcinomas in situ. PDGF-CC serum concentrations varied among BC molecular subtypes. Furthermore, we observed a differential expression of most biomarkers between overweight/obese (body mass index (BMI) ≥ 25 kg/m2) and non-obese patients among the BC molecular subtypes. Finally, the classification of subjects according to menopausal status revealed a significant difference in specific biomarker levels between patients and HD. Conclusion: The serum concentrations of angiogenic molecules differ among breast cancer molecular subtypes and are affected by the BMI and menopausal status, which could have possible clinical or prognostic implications. | ||
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| 650 | 4 | |a body mass index | |
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