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Retroviral vector performance in defined chromosomal loci of modular packaging cell lines

Gamma-Norton and colleagues utilize a technology that relies on the use of packaging cell lines with predefined integration sites to evaluate the performance of several retroviral vectors. According to the authors, this approach enables the systematic design and evaluation of the efficiency and safe...

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Main Authors: Gama-Norton, Leonor (Author) , Herrmann, S. (Author) , Schucht, R. (Author) , Coroadinha, A. S. (Author) , Löw, R. (Author) , Alves, P. M. (Author) , Bartholomä, Cynthia C. (Author) , Schmidt, Manfred (Author) , Baum, C. (Author) , Schambach, A. (Author) , Hauser, H. (Author) , Wirth, D. (Author)
Format: Article (Journal)
Language:English
Published: June 18, 2010
In: Human gene therapy
Year: 2010, Volume: 21, Issue: 8, Pages: 979-991
ISSN:1557-7422
DOI:10.1089/hum.2009.089
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1089/hum.2009.089
Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/hum.2009.089
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Author Notes:L. Gama-Norton, S. Herrmann, R. Schucht, A.S. Coroadinha, R. Löw, P.M. Alves, C.C. Bartholomae, M. Schmidt, C. Baum, A. Schambach, H. Hauser, and D. Wirth
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Summary:Gamma-Norton and colleagues utilize a technology that relies on the use of packaging cell lines with predefined integration sites to evaluate the performance of several retroviral vectors. According to the authors, this approach enables the systematic design and evaluation of the efficiency and safety of retroviral vectors optimized for a given producer cell line.
Item Description:Gesehen am 14.11.2023
Physical Description:Online Resource
ISSN:1557-7422
DOI:10.1089/hum.2009.089

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