Medikamentöse Therapie der Sepsis = Pharmacological therapy of sepsis
The interaction of immunocompetent cells with the vascular endothelium is of prime importance for the development of septic multiple organ failure. There is evidence from in-vitro studies that the methylxanthine derivative pentoxifylline can attenuate the extent of inflammatory reactions by amplific...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | German |
| Published: |
1994
|
| In: |
Der Anaesthesist
Year: 1994, Volume: 43, Issue: 4, Pages: 249-256 |
| ISSN: | 1432-055X |
| DOI: | 10.1007/s001010050055 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s001010050055
|
| Author Notes: | M. Thiel, H.J. Bardenheuer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1870227980 | ||
| 003 | DE-627 | ||
| 005 | 20240311163424.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231114s1994 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.1007/s001010050055 |2 doi | |
| 035 | |a (DE-627)1870227980 | ||
| 035 | |a (DE-599)KXP1870227980 | ||
| 035 | |a (OCoLC)1425896927 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a ger | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Thiel, Manfred |d 1959- |e VerfasserIn |0 (DE-588)1029136874 |0 (DE-627)732482313 |0 (DE-576)376589213 |4 aut | |
| 245 | 1 | 0 | |a Medikamentöse Therapie der Sepsis |b = Pharmacological therapy of sepsis |c M. Thiel, H.J. Bardenheuer |
| 246 | 3 | 1 | |a Pharmacological therapy of sepsis |
| 264 | 1 | |c 1994 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.11.2023 | ||
| 520 | |a The interaction of immunocompetent cells with the vascular endothelium is of prime importance for the development of septic multiple organ failure. There is evidence from in-vitro studies that the methylxanthine derivative pentoxifylline can attenuate the extent of inflammatory reactions by amplification of cell-derived endogenous regulators. For instance, pentoxifylline potentiates the anti-inflammatory actions of adenosine, prostacycline, and prostaglandins of the E series by its synergistic action on intracellular cyclic AMP. By this mechanism, pentoxifylline inhibits the oxygen-radical production of polymorphonuclear leukocytes, the aggregation of platelets, disseminated intravascular coagulation, and the production of cytokines. Consequently, pentoxifylline improves perfusion in the microcirculation as well as tissue oxygenation. Further studies will clarify whether the promising results obtained with pentoxifylline in experimental septic shock will be confirmed under clinical conditions. | ||
| 650 | 4 | |a Key words: Adenosine - Pentoxifylline - cAMP - Sepsis - Therapy | |
| 650 | 4 | |a Schlüsselwörter: Adenosin - Pentoxifyllin - cAMP - Sepsis - Therapie | |
| 700 | 1 | |a Bardenheuer, Hubert J. |e VerfasserIn |0 (DE-588)1064859208 |0 (DE-627)815238819 |0 (DE-576)424204681 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Der Anaesthesist |d Berlin : Springer, 1994 |g 43(1994), 4, Seite 249-256 |h Online-Ressource |w (DE-627)253389771 |w (DE-600)1458421-9 |w (DE-576)072283122 |x 1432-055X |7 nnas |a Medikamentöse Therapie der Sepsis = Pharmacological therapy of sepsis |
| 773 | 1 | 8 | |g volume:43 |g year:1994 |g number:4 |g pages:249-256 |g extent:8 |a Medikamentöse Therapie der Sepsis = Pharmacological therapy of sepsis |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s001010050055 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231114 | ||
| 993 | |a Article | ||
| 994 | |a 1994 | ||
| 998 | |g 1064859208 |a Bardenheuer, Hubert J. |m 1064859208:Bardenheuer, Hubert J. |d 910000 |d 910300 |e 910000PB1064859208 |e 910300PB1064859208 |k 0/910000/ |k 1/910000/910300/ |p 2 |y j | ||
| 999 | |a KXP-PPN1870227980 |e 4406472967 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["ger"],"note":["Gesehen am 14.11.2023"],"id":{"doi":["10.1007/s001010050055"],"eki":["1870227980"]},"physDesc":[{"extent":"8 S."}],"titleTranslated":[{"translated":"Pharmacological therapy of sepsis"}],"title":[{"title_sort":"Medikamentöse Therapie der Sepsis","subtitle":" = Pharmacological therapy of sepsis","title":"Medikamentöse Therapie der Sepsis"}],"origin":[{"dateIssuedKey":"1994","dateIssuedDisp":"1994"}],"relHost":[{"note":["Gesehen am 05.07.2022","Ungezählte Beil. ab 46.1997: Supplement"],"pubHistory":["Volume 43, issue 1 (January 1994) [?]-volume 71, issue 5 (May 2022)"],"language":["ger","eng"],"part":{"text":"43(1994), 4, Seite 249-256","issue":"4","pages":"249-256","extent":"8","year":"1994","volume":"43"},"disp":"Medikamentöse Therapie der Sepsis = Pharmacological therapy of sepsisDer Anaesthesist","type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"253389771","origin":[{"publisherPlace":"Berlin ; Heidelberg ; New York","publisher":"Springer","dateIssuedDisp":"[1994?-2022]"}],"title":[{"title_sort":"Anaesthesist","subtitle":"Zeitschrift für Anästhesie, Intensivmedizin, Notfall- und Katastrophenmedizin, Schmerztherapie ; Organ der Österreichischen Gesellschaft für Anaesthesiologie, Reanimation und Intensivtherapie ; Deutschen Gesellschaft für Anaesthesiologie u. Intensivmedizin ; Schweizerischen Gesellschaft für Anaesthesiologie und Reanimation","title":"Der Anaesthesist"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1458421-9"],"eki":["253389771"],"issn":["1432-055X"]}}],"name":{"displayForm":["M. Thiel, H.J. Bardenheuer"]},"person":[{"role":"aut","family":"Thiel","given":"Manfred","display":"Thiel, Manfred"},{"given":"Hubert J.","display":"Bardenheuer, Hubert J.","family":"Bardenheuer","role":"aut"}],"recId":"1870227980"} | ||
| SRT | |a THIELMANFRMEDIKAMENT1994 | ||