Comprehensive genomic profiling of carcinoma of unknown primary origin: retrospective molecular classification considering the CUPISCO study design
Background. Carcinoma of unknown primary origin (CUP) accounts for 2%-5% of newly diagnosed advanced malignancies, with chemotherapy as the standard of care. CUPISCO (NCT03498521) is an ongoing randomized trial using comprehensive genomic profiling (CGP) to assign patients with CUP to targeted or imm...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2021
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| In: |
The oncologist
Year: 2021, Jahrgang: 26, Heft: 3, Pages: e394-e402 |
| ISSN: | 1549-490X |
| DOI: | 10.1002/onco.13597 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/onco.13597 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/oncolo/article/26/3/e394/6445517 
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| Verfasserangaben: | Jeffrey S. Ross, Ethan S. Sokol, Holger Moch, Linda Mileshkin, Giulia Baciarello, Ferran Losa, Andreas Beringer, Marlene Thomas, Julia A. Elvin, Nhu Ngo, Dexter X. Jin, Alwin Krämer |
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| 520 | |a Background. Carcinoma of unknown primary origin (CUP) accounts for 2%-5% of newly diagnosed advanced malignancies, with chemotherapy as the standard of care. CUPISCO (NCT03498521) is an ongoing randomized trial using comprehensive genomic profiling (CGP) to assign patients with CUP to targeted or immunotherapy treatment arms based on genomic profiling. We performed a retrospective analysis of CUP cases referred for CGP to determine how many were potentially eligible for enrollment into an experimental CUPISCO arm. | ||
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| 700 | 1 | |a Mileshkin, Linda |e VerfasserIn |0 (DE-588)126632755X |0 (DE-627)1815171863 |4 aut | |
| 700 | 1 | |a Baciarello, Giulia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Losa, Ferran |e VerfasserIn |4 aut | |
| 700 | 1 | |a Beringer, Andreas |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Jin, Dexter X. |e VerfasserIn |4 aut | |
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