Pervasive prophage recombination occurs during evolution of spore-forming Bacilli
Phages are the main source of within-species bacterial diversity and drivers of horizontal gene transfer, but we know little about the mechanisms that drive genetic diversity of these mobile genetic elements (MGEs). Recently, we showed that a sporulation selection regime promotes evolutionary change...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
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| In: |
The ISME journal
Year: 2021, Jahrgang: 15, Heft: 5, Pages: 1344-1358 |
| ISSN: | 1751-7370 |
| DOI: | 10.1038/s41396-020-00854-1 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41396-020-00854-1 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41396-020-00854-1 
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| Verfasserangaben: | Anna Dragoš, B. Priyadarshini, Zahraa Hasan, Mikael Lenz Strube, Paul J. Kempen, Gergely Maróti, Charlotte Kaspar, Baundauna Bose, Briana M. Burton, Ilka B. Bischofs, Ákos T. Kovács |
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| 245 | 1 | 0 | |a Pervasive prophage recombination occurs during evolution of spore-forming Bacilli |c Anna Dragoš, B. Priyadarshini, Zahraa Hasan, Mikael Lenz Strube, Paul J. Kempen, Gergely Maróti, Charlotte Kaspar, Baundauna Bose, Briana M. Burton, Ilka B. Bischofs, Ákos T. Kovács |
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| 520 | |a Phages are the main source of within-species bacterial diversity and drivers of horizontal gene transfer, but we know little about the mechanisms that drive genetic diversity of these mobile genetic elements (MGEs). Recently, we showed that a sporulation selection regime promotes evolutionary changes within SPβ prophage of Bacillus subtilis, leading to direct antagonistic interactions within the population. Herein, we reveal that under a sporulation selection regime, SPβ recombines with low copy number phi3Ts phage DNA present within the B. subtilis population. Recombination results in a new prophage occupying a different integration site, as well as the spontaneous release of virulent phage hybrids. Analysis of Bacillus sp. strains suggests that SPβ and phi3T belong to a distinct cluster of unusually large phages inserted into sporulation-related genes that are equipped with a spore-related genetic arsenal. Comparison of Bacillus sp. genomes indicates that similar diversification of SPβ-like phages takes place in nature. Our work is a stepping stone toward empirical studies on phage evolution, and understanding the eco-evolutionary relationships between bacteria and their phages. By capturing the first steps of new phage evolution, we reveal striking relationship between survival strategy of bacteria and evolution of their phages. | ||
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