Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events
Background Rheumatic immune-related adverse events (R-irAEs) occur in 5-15% of patients receiving immune checkpoint inhibitors (ICI) and, unlike other irAEs, tend to be chronic. Herein, we investigate the factors influencing cancer and R-irAEs outcomes with particular focus on adverse effects of ant...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 19, 2023
|
| In: |
Journal for ImmunoTherapy of Cancer
Year: 2023, Volume: 11, Issue: 9, Pages: 1-15 |
| ISSN: | 2051-1426 |
| DOI: | 10.1136/jitc-2023-007557 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1136/jitc-2023-007557 Verlag, kostenfrei, Volltext: https://jitc.bmj.com/content/11/9/e007557 
|
| Author Notes: | Karolina Gente, Leonore Diekmann, Lea Daniello, Julia Will, Manuel Feisst, Victor Olsavszky, Janine Günther, Hanns-Martin Lorenz, M. Margarida Souto-Carneiro, Jessica C. Hassel, Petros Christopoulos, Jan Leipe |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1871296382 | ||
| 003 | DE-627 | ||
| 005 | 20240926162855.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231127s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/jitc-2023-007557 |2 doi | |
| 035 | |a (DE-627)1871296382 | ||
| 035 | |a (DE-599)KXP1871296382 | ||
| 035 | |a (OCoLC)1425209221 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gente, Karolina |d 1986- |e VerfasserIn |0 (DE-588)1066617481 |0 (DE-627)817734120 |0 (DE-576)426070216 |4 aut | |
| 245 | 1 | 0 | |a Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events |c Karolina Gente, Leonore Diekmann, Lea Daniello, Julia Will, Manuel Feisst, Victor Olsavszky, Janine Günther, Hanns-Martin Lorenz, M. Margarida Souto-Carneiro, Jessica C. Hassel, Petros Christopoulos, Jan Leipe |
| 264 | 1 | |c September 19, 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 19. September 2023 | ||
| 500 | |a Gesehen am 27.11.2023 | ||
| 520 | |a Background Rheumatic immune-related adverse events (R-irAEs) occur in 5-15% of patients receiving immune checkpoint inhibitors (ICI) and, unlike other irAEs, tend to be chronic. Herein, we investigate the factors influencing cancer and R-irAEs outcomes with particular focus on adverse effects of anti-inflammatory treatment. - Methods In this prospective, multicenter, long-term, observational study, R-irAEs were comprehensively analyzed in patients with malignant melanoma (MM, n=50) and non-small cell lung cancer (NSCLC, n=41) receiving ICI therapy who were enrolled in the study between August 1, 2018, and December 11, 2022. - Results After a median follow-up of 33 months, progressive disease or death occurred in 66.0% and 30.0% of MM and 63.4% and 39.0% of patients with NSCLC. Male sex (progression-free survival (PFS): p=0.013, and overall survival (OS): p=0.009), flare of a pre-existing condition (vs de novo R-irAE, PFS: p=0.010) and in trend maximum glucocorticoid (GC) doses >10 mg and particularly ≥1 mg/kg prednisolone equivalent (sex-adjusted PFS: p=0.056, OS: p=0.051) were associated with worse cancer outcomes. Patients receiving disease-modifying antirheumatic drugs (DMARDs) showed significantly longer PFS (n=14, p=0.011) and OS (n=20, p=0.018). Effects of these variables on PFS and/or OS persisted in adjusted Cox regression models. Additionally, GC treatment negatively correlated with the time from diagnosis of malignancy and the latency from ICI start until R-irAE onset (all p<0.05). R-irAE features and outcomes were independent of other baseline patient characteristics in both studied cancer entities. - Conclusion Male sex, flare of pre-existing rheumatologic conditions and extensive GC treatment appeared to be linked with unfavorable cancer outcomes, while DMARD use had a favorable impact. These findings challenge the current dogma of restrictive DMARD use for R-irAE and thus may pave the way to better strategies and randomized controlled trials for the growing number of patients with R-irAE. | ||
| 650 | 4 | |a Immune Checkpoint Inhibitors | |
| 650 | 4 | |a Immunotherapy | |
| 650 | 4 | |a Melanoma | |
| 650 | 4 | |a Non-Small Cell Lung Cancer | |
| 650 | 4 | |a rheumatic immune-related adverse event | |
| 700 | 1 | |a Diekmann, Leonore |d 1995- |e VerfasserIn |0 (DE-588)1292592443 |0 (DE-627)1848810164 |4 aut | |
| 700 | 1 | |a Daniello, Lea |d 1997- |e VerfasserIn |0 (DE-588)1238304303 |0 (DE-627)1765667739 |4 aut | |
| 700 | 1 | |a Will, Julia |e VerfasserIn |0 (DE-588)1311319336 |0 (DE-627)1871297338 |4 aut | |
| 700 | 1 | |a Feißt, Manuel |d 1989- |e VerfasserIn |0 (DE-588)1158520948 |0 (DE-627)1020533544 |0 (DE-576)504012312 |4 aut | |
| 700 | 1 | |a Olsavszky, Victor |d 1988- |e VerfasserIn |0 (DE-588)1157102999 |0 (DE-627)1020140542 |0 (DE-576)306357585 |4 aut | |
| 700 | 1 | |a Günther, Janine |e VerfasserIn |0 (DE-588)1210873311 |0 (DE-627)1698736061 |4 aut | |
| 700 | 1 | |a Lorenz, Hanns-Martin |d 1962- |e VerfasserIn |0 (DE-588)112253865 |0 (DE-627)627277845 |0 (DE-576)167601369 |4 aut | |
| 700 | 1 | |a Souto-Carneiro, Maria Margarida |d 1973- |e VerfasserIn |0 (DE-588)122890698 |0 (DE-627)082217696 |0 (DE-576)293465649 |4 aut | |
| 700 | 1 | |a Hassel, Jessica C. |d 1975- |e VerfasserIn |0 (DE-588)129790702 |0 (DE-627)480399069 |0 (DE-576)29783715X |4 aut | |
| 700 | 1 | |a Christopoulos, Petros |d 1977- |e VerfasserIn |0 (DE-588)138659702 |0 (DE-627)604886756 |0 (DE-576)308488067 |4 aut | |
| 700 | 1 | |a Leipe, Jan |d 1976- |e VerfasserIn |0 (DE-588)131797824 |0 (DE-627)51426280X |0 (DE-576)298758563 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal for ImmunoTherapy of Cancer |d London : BioMed Central, 2013 |g 11(2023), 9, Artikel-ID e007557, Seite 1-15 |h Online-Ressource |w (DE-627)750086335 |w (DE-600)2719863-7 |w (DE-576)383767369 |x 2051-1426 |7 nnas |a Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events |
| 773 | 1 | 8 | |g volume:11 |g year:2023 |g number:9 |g elocationid:e007557 |g pages:1-15 |g extent:15 |a Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events |
| 856 | 4 | 0 | |u https://doi.org/10.1136/jitc-2023-007557 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://jitc.bmj.com/content/11/9/e007557 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231127 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 131797824 |a Leipe, Jan |m 131797824:Leipe, Jan |d 60000 |d 61400 |e 60000PL131797824 |e 61400PL131797824 |k 0/60000/ |k 1/60000/61400/ |p 12 |y j | ||
| 998 | |g 138659702 |a Christopoulos, Petros |m 138659702:Christopoulos, Petros |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PC138659702 |e 950000PC138659702 |e 950900PC138659702 |e 50000PC138659702 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 11 | ||
| 998 | |g 129790702 |a Hassel, Jessica C. |m 129790702:Hassel, Jessica C. |d 910000 |d 911300 |d 50000 |e 910000PH129790702 |e 911300PH129790702 |e 50000PH129790702 |k 0/910000/ |k 1/910000/911300/ |k 0/50000/ |p 10 | ||
| 998 | |g 122890698 |a Souto-Carneiro, Maria Margarida |m 122890698:Souto-Carneiro, Maria Margarida |d 910000 |d 910100 |e 910000PS122890698 |e 910100PS122890698 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 112253865 |a Lorenz, Hanns-Martin |m 112253865:Lorenz, Hanns-Martin |d 910000 |d 910100 |e 910000PL112253865 |e 910100PL112253865 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 1210873311 |a Günther, Janine |m 1210873311:Günther, Janine |p 7 | ||
| 998 | |g 1157102999 |a Olsavszky, Victor |m 1157102999:Olsavszky, Victor |d 60000 |d 61900 |e 60000PO1157102999 |e 61900PO1157102999 |k 0/60000/ |k 1/60000/61900/ |p 6 | ||
| 998 | |g 1158520948 |a Feißt, Manuel |m 1158520948:Feißt, Manuel |d 910000 |d 911800 |e 910000PF1158520948 |e 911800PF1158520948 |k 0/910000/ |k 1/910000/911800/ |p 5 | ||
| 998 | |g 1311319336 |a Will, Julia |m 1311319336:Will, Julia |p 4 | ||
| 998 | |g 1238304303 |a Daniello, Lea |m 1238304303:Daniello, Lea |d 910000 |d 910100 |e 910000PD1238304303 |e 910100PD1238304303 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1066617481 |a Gente, Karolina |m 1066617481:Gente, Karolina |d 910000 |d 910100 |e 910000PG1066617481 |e 910100PG1066617481 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1871296382 |e 4418493514 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Online veröffentlicht: 19. September 2023","Gesehen am 27.11.2023"],"relHost":[{"recId":"750086335","disp":"Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse eventsJournal for ImmunoTherapy of Cancer","language":["eng"],"pubHistory":["1.2013 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedKey":"2013","publisherPlace":"London","publisher":"BioMed Central","dateIssuedDisp":"2013-"}],"title":[{"title":"Journal for ImmunoTherapy of Cancer","title_sort":"Journal for ImmunoTherapy of Cancer","subtitle":"official journal of the Society for Immunotherapy of Cancer (SITC)"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["750086335"],"zdb":["2719863-7"],"issn":["2051-1426"]},"part":{"issue":"9","extent":"15","text":"11(2023), 9, Artikel-ID e007557, Seite 1-15","volume":"11","pages":"1-15","year":"2023"},"note":["Gesehen am 29.06.20"]}],"physDesc":[{"extent":"15 S.","noteIll":"Illustrationen"}],"id":{"eki":["1871296382"],"doi":["10.1136/jitc-2023-007557"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events","title_sort":"Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events"}],"language":["eng"],"person":[{"role":"aut","given":"Karolina","display":"Gente, Karolina","family":"Gente"},{"role":"aut","family":"Diekmann","display":"Diekmann, Leonore","given":"Leonore"},{"role":"aut","family":"Daniello","display":"Daniello, Lea","given":"Lea"},{"role":"aut","given":"Julia","display":"Will, Julia","family":"Will"},{"given":"Manuel","display":"Feißt, Manuel","family":"Feißt","role":"aut"},{"role":"aut","display":"Olsavszky, Victor","given":"Victor","family":"Olsavszky"},{"role":"aut","family":"Günther","given":"Janine","display":"Günther, Janine"},{"role":"aut","display":"Lorenz, Hanns-Martin","given":"Hanns-Martin","family":"Lorenz"},{"family":"Souto-Carneiro","given":"Maria Margarida","display":"Souto-Carneiro, Maria Margarida","role":"aut"},{"family":"Hassel","display":"Hassel, Jessica C.","given":"Jessica C.","role":"aut"},{"role":"aut","family":"Christopoulos","given":"Petros","display":"Christopoulos, Petros"},{"family":"Leipe","given":"Jan","display":"Leipe, Jan","role":"aut"}],"origin":[{"dateIssuedDisp":"September 19, 2023","dateIssuedKey":"2023"}],"name":{"displayForm":["Karolina Gente, Leonore Diekmann, Lea Daniello, Julia Will, Manuel Feisst, Victor Olsavszky, Janine Günther, Hanns-Martin Lorenz, M. Margarida Souto-Carneiro, Jessica C. Hassel, Petros Christopoulos, Jan Leipe"]},"recId":"1871296382"} | ||
| SRT | |a GENTEKAROLSEXANDANTI1920 | ||