Impact of etiology on disease course in chronic pancreatitis
Background: Complications in chronic pancreatitis (CP) can be grouped in inflammatory (ICC) and fibrotic (FCC) clusters and pancreatic insufficiency cluster (PIC). However, the association between etiological risk factors and the development of complication clusters remains obscure. In this study, the...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 June 2023
|
| In: |
Pancreatology
Year: 2023, Jahrgang: 23, Heft: 6, Pages: 582-588 |
| ISSN: | 1424-3911 |
| DOI: | 10.1016/j.pan.2023.06.015 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.pan.2023.06.015 Verlag, lizenzpflichtig, Volltext: https://linkinghub.elsevier.com/retrieve/pii/S1424390323005732 
|
| Verfasserangaben: | Katharina Murillo, Onur Simsek, Philipp Göltl, Maximilian Wekerle, Philip Hardt, Natalia Gubergrits, Svetlana Hetjens, Matthias P. Ebert, Alexander Schneider, Michael Hirth |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1871303605 | ||
| 003 | DE-627 | ||
| 005 | 20240314153112.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231127s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pan.2023.06.015 |2 doi | |
| 035 | |a (DE-627)1871303605 | ||
| 035 | |a (DE-599)KXP1871303605 | ||
| 035 | |a (OCoLC)1425209219 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Murillo, Katharina |d 1989- |e VerfasserIn |0 (DE-588)1168754798 |0 (DE-627)1032529148 |0 (DE-576)511718713 |4 aut | |
| 245 | 1 | 0 | |a Impact of etiology on disease course in chronic pancreatitis |c Katharina Murillo, Onur Simsek, Philipp Göltl, Maximilian Wekerle, Philip Hardt, Natalia Gubergrits, Svetlana Hetjens, Matthias P. Ebert, Alexander Schneider, Michael Hirth |
| 264 | 1 | |c 26 June 2023 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.11.2023 | ||
| 520 | |a Background: Complications in chronic pancreatitis (CP) can be grouped in inflammatory (ICC) and fibrotic (FCC) clusters and pancreatic insufficiency cluster (PIC). However, the association between etiological risk factors and the development of complication clusters remains obscure. In this study, the impact of the etiology and disease duration on disease onset and development of complications was investigated. - Methods: This cross-sectional study recruited patients with CP from Mannheim/Germany (n ¼ 870), Gieben/Germany (n ¼ 100) und Donetsk/Ukraine (n ¼ 104). Etiological risk factors, disease stage, age at disease onset, complications, need for hospitalization and surgery were noted. - Results: In 1074 patients diagnosed with CP, main risk factors were alcohol and nicotine abuse. An earlier onset of the disease was observed upon nicotine abuse (À4.0 years). Alcohol abuse was only associated with an earlier onset of the definite stage of CP. Alcohol abuse was the major risk factor for the development of ICC (p < 0.0001, multiple regression modeling). Abstinence of alcohol reduced ICC, whereas abstinence of nicotine showed no association. PIC correlated with efferent duct abnormalities and the disease duration. In contrast, FCC was mainly dependent on the disease duration (p < 0.0001; t-test). The presence of any complication cluster correlated with the need for surgery (p < 0.01; X2-test). However, only ICC correlated with a prolonged hospital stay (p < 0.05; t-test). - Conclusions: ICC is mainly dependent on alcohol abuse. In contrast, FCC and PIC are mainly dependent on the disease duration. The etiology and disease duration can be used as predictors of the course of disease to provide individual treatment and surveillance strategies. | ||
| 700 | 1 | |a Simsek, Onur |d 1987- |e VerfasserIn |0 (DE-588)1323488197 |0 (DE-627)1883458870 |4 aut | |
| 700 | 1 | |a Göltl, Philipp |d 1995- |e VerfasserIn |0 (DE-588)1323488413 |0 (DE-627)1883459362 |4 aut | |
| 700 | 1 | |a Wekerle, Maximilian |d 1994- |e VerfasserIn |0 (DE-588)1323488634 |0 (DE-627)1883459869 |4 aut | |
| 700 | 1 | |a Hardt, Philip |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gubergrits, Natalia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hetjens, Svetlana |d 1983- |e VerfasserIn |0 (DE-588)1031801979 |0 (DE-627)737600284 |0 (DE-576)379534223 |4 aut | |
| 700 | 1 | |a Ebert, Matthias |d 1968- |e VerfasserIn |0 (DE-588)1030133522 |0 (DE-627)734827083 |0 (DE-576)377938432 |4 aut | |
| 700 | 1 | |a Schneider, Alexander |d 1971- |e VerfasserIn |0 (DE-588)120533448 |0 (DE-627)696757583 |0 (DE-576)250454335 |4 aut | |
| 700 | 1 | |a Hirth, Michael |d 1986- |e VerfasserIn |0 (DE-588)1051645808 |0 (DE-627)786507624 |0 (DE-576)406937281 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pancreatology |d Amsterdam : Elsevier, 2001 |g 23(2023), 6, Seite 582-588 |h Online-Ressource |w (DE-627)32764432X |w (DE-600)2043694-4 |w (DE-576)110513657 |x 1424-3911 |7 nnas |a Impact of etiology on disease course in chronic pancreatitis |
| 773 | 1 | 8 | |g volume:23 |g year:2023 |g number:6 |g pages:582-588 |g extent:7 |a Impact of etiology on disease course in chronic pancreatitis |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.pan.2023.06.015 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://linkinghub.elsevier.com/retrieve/pii/S1424390323005732 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231127 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1051645808 |a Hirth, Michael |m 1051645808:Hirth, Michael |d 60000 |e 60000PH1051645808 |k 0/60000/ |p 10 |y j | ||
| 998 | |g 120533448 |a Schneider, Alexander |m 120533448:Schneider, Alexander |d 60000 |e 60000PS120533448 |k 0/60000/ |p 9 | ||
| 998 | |g 1030133522 |a Ebert, Matthias |m 1030133522:Ebert, Matthias |d 60000 |d 61100 |e 60000PE1030133522 |e 61100PE1030133522 |k 0/60000/ |k 1/60000/61100/ |p 8 | ||
| 998 | |g 1323488634 |a Wekerle, Maximilian |m 1323488634:Wekerle, Maximilian |d 60000 |d 61100 |e 60000PW1323488634 |e 61100PW1323488634 |k 0/60000/ |k 1/60000/61100/ |p 4 | ||
| 998 | |g 1323488413 |a Göltl, Philipp |m 1323488413:Göltl, Philipp |d 60000 |d 61100 |e 60000PG1323488413 |e 61100PG1323488413 |k 0/60000/ |k 1/60000/61100/ |p 3 | ||
| 998 | |g 1323488197 |a Simsek, Onur |m 1323488197:Simsek, Onur |p 2 | ||
| 998 | |g 1031801979 |a Hetjens, Svetlana |m 1031801979:Hetjens, Svetlana |d 60000 |d 60200 |d 60250 |e 60000PH1031801979 |e 60200PH1031801979 |e 60250PH1031801979 |k 0/60000/ |k 1/60000/60200/ |k 2/60000/60200/60250/ |p 7 | ||
| 998 | |g 1168754798 |a Murillo, Katharina |m 1168754798:Murillo, Katharina |d 60000 |d 61100 |e 60000PM1168754798 |e 61100PM1168754798 |k 0/60000/ |k 1/60000/61100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1871303605 |e 4418510303 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Impact of etiology on disease course in chronic pancreatitis","title_sort":"Impact of etiology on disease course in chronic pancreatitis"}],"person":[{"role":"aut","display":"Murillo, Katharina","given":"Katharina","family":"Murillo"},{"family":"Simsek","given":"Onur","display":"Simsek, Onur","role":"aut"},{"display":"Göltl, Philipp","family":"Göltl","given":"Philipp","role":"aut"},{"role":"aut","family":"Wekerle","given":"Maximilian","display":"Wekerle, Maximilian"},{"role":"aut","display":"Hardt, Philip","family":"Hardt","given":"Philip"},{"role":"aut","display":"Gubergrits, Natalia","family":"Gubergrits","given":"Natalia"},{"family":"Hetjens","given":"Svetlana","display":"Hetjens, Svetlana","role":"aut"},{"role":"aut","family":"Ebert","given":"Matthias","display":"Ebert, Matthias"},{"role":"aut","family":"Schneider","given":"Alexander","display":"Schneider, Alexander"},{"given":"Michael","family":"Hirth","display":"Hirth, Michael","role":"aut"}],"origin":[{"dateIssuedDisp":"26 June 2023","dateIssuedKey":"2023"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 27.11.2023"],"id":{"eki":["1871303605"],"doi":["10.1016/j.pan.2023.06.015"]},"recId":"1871303605","name":{"displayForm":["Katharina Murillo, Onur Simsek, Philipp Göltl, Maximilian Wekerle, Philip Hardt, Natalia Gubergrits, Svetlana Hetjens, Matthias P. Ebert, Alexander Schneider, Michael Hirth"]},"relHost":[{"language":["eng"],"part":{"text":"23(2023), 6, Seite 582-588","issue":"6","year":"2023","extent":"7","pages":"582-588","volume":"23"},"disp":"Impact of etiology on disease course in chronic pancreatitisPancreatology","physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2043694-4"],"issn":["1424-3911"],"eki":["32764432X"]},"recId":"32764432X","note":["Gesehen am 09.01.2019"],"origin":[{"dateIssuedKey":"2001","publisher":"Elsevier ; Karger","dateIssuedDisp":"2001-","publisherPlace":"Amsterdam ; Basel"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2001 -"],"title":[{"title":"Pancreatology","title_sort":"Pancreatology","subtitle":"official journal of the International Association of Pancreatology (IAP) and the European Pancreatic Club (EPC)"}]}],"physDesc":[{"extent":"7 S."}],"language":["eng"]} | ||
| SRT | |a MURILLOKATIMPACTOFET2620 | ||