Cover Image

Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Background - Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney. - Method - We aimed to document a potential association between 25-hydroxyvitamin D [25(OH)D...

Full description

Saved in:
Bibliographic Details
Main Authors: Tomaschitz, Andreas (Author) , Pilz, Stefan (Author) , Ritz, Eberhard (Author) , Grammer, Tanja B. (Author) , Drechsler, Christiane (Author) , Boehm, Bernhard O. (Author) , März, Winfried (Author)
Format: Article (Journal)
Language:English
Published: 1 June 2010
In: Clinica chimica acta
Year: 2010, Volume: 411, Issue: 17/18, Pages: 1354-1360
ISSN:1873-3492
DOI:10.1016/j.cca.2010.05.037
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cca.2010.05.037
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0009898110003700
Get full text
Author Notes:Andreas Tomaschitz, Stefan Pilz, Eberhard Ritz, Tanja Grammer, Christiane Drechsler, Bernhard O. Boehm, Winfried März

MARC

LEADER 00000caa a2200000 c 4500
001 1871444314
003 DE-627
005 20240311121258.0
007 cr uuu---uuuuu
008 231128s2010 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.cca.2010.05.037  |2 doi 
035 |a (DE-627)1871444314 
035 |a (DE-599)KXP1871444314 
035 |a (OCoLC)1425872899 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 30  |2 sdnb 
100 1 |a Tomaschitz, Andreas  |e VerfasserIn  |0 (DE-588)106940036X  |0 (DE-627)821859072  |0 (DE-576)428670458  |4 aut 
245 1 0 |a Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system  |b the Ludwigshafen Risk and Cardiovascular Health (LURIC) study  |c Andreas Tomaschitz, Stefan Pilz, Eberhard Ritz, Tanja Grammer, Christiane Drechsler, Bernhard O. Boehm, Winfried März 
264 1 |c 1 June 2010 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 28.11.2023 
520 |a Background - Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney. - Method - We aimed to document a potential association between 25-hydroxyvitamin D [25(OH)D], 1,25(OH)2D and the circulating renin-angiotensin system (RAS) in a large cohort of patients referred (n=3316) to coronary angiography. - Results - Of the 3316 subjects, 3296 (median age: 63.5 (56.3-70.6)years; 30.2% women) had a baseline measurement of 25(OH)D [median: 15.6(10.1-23.0)µg/L)], 1,25(OH)2D [median: 33.2(25.2-42.9)pg/mL], plasma renin concentration [PRC; median: 11.4(6.0-24.6)pg/mL] and angiotensin 2 [median: 20.0(12.0-35.0)ng/L]. Multivariate adjusted ANCOVA showed a steady increase of PRC values across declining deciles of 25(OH)D and 1,25(OH)2D values (P=0.013 and P=0.045), respectively. Additionally, mean angiotensin 2 values increased significantly across decreasing 25(OH)D and 1,25(OH)2D values (P=0.020 and P=0.024, respectively). In contrast, multivariate adjusted ANCOVA revealed no significant associations between aldosterone, aldosterone-to-renin ratio and 25(OH)D/1,25(OH)2D values. In multivariate stepwise regression analyses both, 25(OH)D and 1,25(OH)2D emerged as independent predictors of plasma renin and angiotensin 2 concentrations. - Conclusions - Our data showed for the first time in humans that both, lower 25(OH)D and 1,25(OH)2D values are independently related to an upregulated circulating RAS. 
650 4 |a Renin-angiotensin system 
650 4 |a Vitamin D 
700 1 |a Pilz, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Ritz, Eberhard  |d 1938-2023  |e VerfasserIn  |0 (DE-588)106673386  |0 (DE-627)610528866  |0 (DE-576)311552501  |4 aut 
700 1 |a Grammer, Tanja B.  |d 1972-  |e VerfasserIn  |0 (DE-588)1030134952  |0 (DE-627)734830041  |0 (DE-576)377941018  |4 aut 
700 1 |a Drechsler, Christiane  |e VerfasserIn  |4 aut 
700 1 |a Boehm, Bernhard O.  |e VerfasserIn  |4 aut 
700 1 |a März, Winfried  |d 1958-  |e VerfasserIn  |0 (DE-588)1027603599  |0 (DE-627)729463605  |0 (DE-576)373454635  |4 aut 
773 0 8 |i Enthalten in  |t Clinica chimica acta  |d Amsterdam [u.a.] : Elsevier Science, 1956  |g 411(2010), 17/18, Seite 1354-1360  |h Online-Ressource  |w (DE-627)306654423  |w (DE-600)1499920-1  |w (DE-576)094531242  |x 1873-3492  |7 nnas  |a Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system the Ludwigshafen Risk and Cardiovascular Health (LURIC) study 
773 1 8 |g volume:411  |g year:2010  |g number:17/18  |g pages:1354-1360  |g extent:7  |a Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system the Ludwigshafen Risk and Cardiovascular Health (LURIC) study 
856 4 0 |u https://doi.org/10.1016/j.cca.2010.05.037  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0009898110003700  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20231128 
993 |a Article 
994 |a 2010 
998 |g 1027603599  |a März, Winfried  |m 1027603599:März, Winfried  |d 60000  |e 60000PM1027603599  |k 0/60000/  |p 7  |y j 
998 |g 1030134952  |a Grammer, Tanja B.  |m 1030134952:Grammer, Tanja B.  |d 60000  |e 60000PG1030134952  |k 0/60000/  |p 4 
998 |g 106673386  |a Ritz, Eberhard  |m 106673386:Ritz, Eberhard  |d 910000  |d 910100  |e 910000PR106673386  |e 910100PR106673386  |k 0/910000/  |k 1/910000/910100/  |p 3 
999 |a KXP-PPN1871444314  |e 4419225726 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"given":"Andreas","family":"Tomaschitz","role":"aut","display":"Tomaschitz, Andreas"},{"given":"Stefan","family":"Pilz","role":"aut","display":"Pilz, Stefan"},{"display":"Ritz, Eberhard","role":"aut","family":"Ritz","given":"Eberhard"},{"given":"Tanja B.","family":"Grammer","role":"aut","display":"Grammer, Tanja B."},{"family":"Drechsler","given":"Christiane","display":"Drechsler, Christiane","role":"aut"},{"role":"aut","display":"Boehm, Bernhard O.","given":"Bernhard O.","family":"Boehm"},{"display":"März, Winfried","role":"aut","family":"März","given":"Winfried"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1871444314"],"doi":["10.1016/j.cca.2010.05.037"]},"physDesc":[{"extent":"7 S."}],"relHost":[{"language":["eng"],"title":[{"title_sort":"Clinica chimica acta","title":"Clinica chimica acta","subtitle":"international journal of clinical chemistry and applied molecular biology"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system the Ludwigshafen Risk and Cardiovascular Health (LURIC) studyClinica chimica acta","note":["Gesehen am 04.02.20"],"part":{"text":"411(2010), 17/18, Seite 1354-1360","pages":"1354-1360","issue":"17/18","year":"2010","extent":"7","volume":"411"},"pubHistory":["1.1956 -"],"id":{"issn":["1873-3492"],"zdb":["1499920-1"],"eki":["306654423"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"306654423","origin":[{"dateIssuedDisp":"1956-","publisher":"Elsevier Science","dateIssuedKey":"1956","publisherPlace":"Amsterdam [u.a.]"}]}],"title":[{"title_sort":"Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system","subtitle":"the Ludwigshafen Risk and Cardiovascular Health (LURIC) study","title":"Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system"}],"name":{"displayForm":["Andreas Tomaschitz, Stefan Pilz, Eberhard Ritz, Tanja Grammer, Christiane Drechsler, Bernhard O. Boehm, Winfried März"]},"recId":"1871444314","note":["Gesehen am 28.11.2023"],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"1 June 2010"}]} 
SRT |a TOMASCHITZINDEPENDEN1201 

Similar Items