Sex-biased gene expression across mammalian organ development and evolution
Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using a resource of gene expression profiles in males and females throughout the develop...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
3 Nov 2023
|
| In: |
Science
Year: 2023, Volume: 382, Pages: 1-13 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.adf1046 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.adf1046 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.adf1046 
|
| Author Notes: | Leticia Rodríguez-Montes, Svetlana Ovchinnikova, Xuefei Yuan, Tania Studer, Ioannis Sarropoulos, Simon Anders, Henrik Kaessmann, Margarida Cardoso-Moreira |
| Summary: | Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using a resource of gene expression profiles in males and females throughout the development of five organs in five mammals (human, mouse, rat, rabbit, and opossum) and a bird (chicken). We found that sex-biased gene expression varied considerably across organs and species and was often cell-type specific. Sex differences increased abruptly around sexual maturity instead of increasing gradually during organ development. Finally, sex-biased gene expression evolved rapidly at the gene level, with differences between organs in the evolutionary mechanisms used, but more slowly at the cellular level, with the same cell types being sexually dimorphic across species. |
|---|---|
| Item Description: | Gesehen am 28.11.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.adf1046 |