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Immune responses in mice after immunization with antigens from different stages of the parasite schistosoma mansoni

Mice responses to immunization with Schistosoma mansoni antigens were investigated. Priming with cercarial antigen preparation (CAP) induced significant (P < 0.05) IgM, IgG, IgG2a, IgG2b, and IgA increases, while booster caused a significant IgG1 increase. A soluble worm antigen preparation (SWAP...

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Hauptverfasser: Gaber, Hanaa M. (VerfasserIn) , Maghraby, Amany S. (VerfasserIn) , Ahmed, Mohamed Bastawy (VerfasserIn) , Ruppel, Andreas (VerfasserIn) , Riad, Mahmoud (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2010
In: Zeitschrift für Naturforschung. C, a journal of biosciences
Year: 2010, Jahrgang: 65, Heft: 3/4, Pages: 289-302
ISSN:1865-7125
DOI:10.1515/znc-2010-3-419
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1515/znc-2010-3-419
Verlag, kostenfrei, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/znc-2010-3-419/html
Volltext
Verfasserangaben:Hanaa M. Gaber, Amany S. Maghraby, Mohamed Bastawy Ahmed, Andreas Ruppel, and Mahmoud M. Bahgat
Beschreibung
Zusammenfassung:Mice responses to immunization with Schistosoma mansoni antigens were investigated. Priming with cercarial antigen preparation (CAP) induced significant (P < 0.05) IgM, IgG, IgG2a, IgG2b, and IgA increases, while booster caused a significant IgG1 increase. A soluble worm antigen preparation (SWAP) caused significant IgG elevation. Priming with soluble egg antigen (SEA) caused significant IgM and IgG2a increases, while booster induced significant IgM, IgG and IgA increases. CAP-immunized mice sera (IMS) recognized CAP peptides ranging from 23 - 78 kDa. SWAP-IMS recognized SWAP peptides ranging from 40 - 75 kDa. SEA-IMS recognized SEA peptides ranging from 33 - 101 kDa. The cross-reactive peptides among the 3 antigens were identified. CAP caused significant increases in mesenteric lymph nodes (MLNs) CD 4,8 + , B lymphocytes, CD 8 + thymocytes, CD 4 + T and B splenocytes. SWAP priming caused significant increases in MLNs CD 4,8 + thymocytes and B splenocytes. SWAP booster caused significant increases in MLNs CD 8 + T and B lymphocytes, CD 4,8 + thymocytes and CD 4 + T and B splenocytes. SEA caused significant increase in CD 4 + T cells.
Beschreibung:Gesehen am 28.11.2023
Beschreibung:Online Resource
ISSN:1865-7125
DOI:10.1515/znc-2010-3-419

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