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Placental interleukin-15 expression in recurrent miscarriage

Citation Toth B, Haufe T, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U. Placental Interleukin-15 expression in recurrent miscarriage. Am J Reprod Immunol 2010; 64: 402-410 Problem Cytokines play a fundamental role at the feto-maternal interface. A dysregulation of the cytokin...

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Main Authors: Toth, Bettina (Author) , Haufe, Thomas (Author) , Scholz, Christoph (Author) , Kuhn, Christina (Author) , Friese, Klaus (Author) , Karamouti, Maria (Author) , Makrigiannakis, Antonis (Author) , Jeschke, Udo (Author)
Format: Article (Journal)
Language:English
Published: 03 November 2010
In: American journal of reproductive immunology
Year: 2010, Volume: 64, Issue: 6, Pages: 402-410
ISSN:1600-0897
DOI:10.1111/j.1600-0897.2010.00879.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0897.2010.00879.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0897.2010.00879.x
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Author Notes:Bettina Toth, Thomas Haufe, Christoph Scholz, Christina Kuhn, Klaus Friese, Maria Karamouti, Antonis Makrigiannakis, Udo Jeschke

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520 |a Citation Toth B, Haufe T, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U. Placental Interleukin-15 expression in recurrent miscarriage. Am J Reprod Immunol 2010; 64: 402-410 Problem Cytokines play a fundamental role at the feto-maternal interface. A dysregulation of the cytokine profile could be linked with fetal rejection. This study investigated differences in the expression of the Th1 cytokine interleukin-15 (IL-15) of normal and disturbed pregnancy. Method of study Analysis of IL-15 expression by immunohistochemistry and real-time RT-PCR in placental tissue from normal pregnancies, spontaneous miscarriage and recurrent miscarriage (RM) was performed. Results Expression of IL-15 was upregulated on mRNA and protein level in the placenta of miscarriage patients, especially in patients with RM. Immunohistochemistry and immunofluorescence double staining revealed extravillous trophoblast cells (EVT) as IL-15-expressing cells. Staining results were confirmed by real-time PCR (TaqMan). Conclusion Increased expression of IL-15 in the decidua of patients with RM may be linked to disturbed implantation and vascularization with consecutive placental and fetal rejection. 
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