Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma: a prospective multi-center study
Background: Patients with recurrent oral squamous cell carcinoma (OSCC) have limited treatment options. Salvage surgery offers potential curative therapy. The need for extensive ablative surgery together with microvascular reconstruction implies invasive and painful treatment with questionable funct...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 October 2023
|
| In: |
Journal of Clinical Medicine
Year: 2023, Jahrgang: 12, Heft: 20, Pages: 1-12 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm12206602 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm12206602 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/12/20/6602 
|
| Verfasserangaben: | Sven Zittel, Julius Moratin, Sinclair Awounvo, Thomas Rückschloß, Kolja Freier, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Christian Freudlsperger and Dominik Horn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1871573947 | ||
| 003 | DE-627 | ||
| 005 | 20240307035809.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231129s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/jcm12206602 |2 doi | |
| 035 | |a (DE-627)1871573947 | ||
| 035 | |a (DE-599)KXP1871573947 | ||
| 035 | |a (OCoLC)1425209104 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zittel, Sven |d 1986- |e VerfasserIn |0 (DE-588)1075611253 |0 (DE-627)83354859X |0 (DE-576)444404228 |4 aut | |
| 245 | 1 | 0 | |a Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma |b a prospective multi-center study |c Sven Zittel, Julius Moratin, Sinclair Awounvo, Thomas Rückschloß, Kolja Freier, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Christian Freudlsperger and Dominik Horn |
| 264 | 1 | |c 18 October 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.11.2023 | ||
| 520 | |a Background: Patients with recurrent oral squamous cell carcinoma (OSCC) have limited treatment options. Salvage surgery offers potential curative therapy. The need for extensive ablative surgery together with microvascular reconstruction implies invasive and painful treatment with questionable functional outcome. To address the impact of salvage surgery on the health-related quality of life (HRQoL) of patients suffering from recurrent OSCC, a multi-center prospective analysis was initiated. Material and Methods: Patients with recurrent OSCC from 2015 to 2022 at two German cancer centers were included. Interdisciplinary tumor board decisions determined surgery as the only curative treatment modality. HRQoL, was assessed via a EORTC questionnaire (European Organization for Research and Treatment of Cancer—EORTC: QLQ-C30 and QLQ-H&N35) in dependence of the recurrent tumor stage. Patients completed the questionnaires once before surgery (baseline) and then every 3 months during follow-up or up to the end of treatment. Results: In total, 55 patients were included. The mean follow-up period was 26.7 ± 19.3 months. Global health status showed superior mean scores after 12 months (60.83 ± 22.58) compared to baseline (53.33 ± 26.41) in stage 1 and 2 recurrent tumors. In advanced recurrent tumors’ mean scores for global health showed only minor positive differences after 12 months (55.13 ± 22.7) compared to baseline (53.2 ± 25.58). In terms of the mouth pain, mean scores were lower after salvage surgery in small recurrent tumors after 12 months (20.37 ± 17.73) compared to baseline (41.67 ± 33.07; Wilcoxon two-sample signed-rank test p = 0.028). In advanced recurrent tumors, a significant reduction in mean scores was detected 3 months after salvage surgery (29.7 ± 22.94) compared to baseline (47.76 ± 25.77; Wilcoxon two-sample signed-rank test p = 0.003). Up to 12 months, swallowing function was evaluated inferior compared to baseline independent of tumor stage (Mean score recurrent stage I/II: 12-months 48.15 ± 27.57, baseline 28.7 ± 22.87; stage III/IV: 12-months 49.36.42 ± 27.53; baseline 30.13 ± 26.25). Conclusion: Improved HRQoL could be obtained in advanced recurrent OSCC after salvage surgery despite reduced swallowing function. In small recurrent tumors, overall, HRQoL was superior to baseline. Salvage surgery positively affected pain burden. For advanced recurrent tumors, important pain relieve could be observed as soon as 3 months after surgery. | ||
| 650 | 4 | |a EORTC | |
| 650 | 4 | |a oral squamous cell carcinoma | |
| 650 | 4 | |a quality of life | |
| 650 | 4 | |a recurrent oral squamous cell carcinoma | |
| 650 | 4 | |a salvage surgery | |
| 700 | 1 | |a Moratin, Julius |d 1987- |e VerfasserIn |0 (DE-588)1048605442 |0 (DE-627)780714784 |0 (DE-576)402453190 |4 aut | |
| 700 | 1 | |a Awounvo Awounvo, Junior Sinclair |e VerfasserIn |0 (DE-588)1306960894 |0 (DE-627)1867294869 |4 aut | |
| 700 | 1 | |a Rückschloß, Thomas |d 1992- |e VerfasserIn |0 (DE-588)1136095136 |0 (DE-627)891242937 |0 (DE-576)49031838X |4 aut | |
| 700 | 1 | |a Freier, Kolja |d 1973- |e VerfasserIn |0 (DE-588)128789972 |0 (DE-627)380633396 |0 (DE-576)18748144X |4 aut | |
| 700 | 1 | |a Ristow, Oliver |e VerfasserIn |0 (DE-588)1064833276 |0 (DE-627)815203608 |0 (DE-576)424174545 |4 aut | |
| 700 | 1 | |a Engel, Michael |d 1972- |e VerfasserIn |0 (DE-588)132967367 |0 (DE-627)52919421X |0 (DE-576)264912454 |4 aut | |
| 700 | 1 | |a Hoffmann, Jürgen |d 1965- |e VerfasserIn |0 (DE-588)1032524456 |0 (DE-627)738520063 |0 (DE-576)380087189 |4 aut | |
| 700 | 1 | |a Freudlsperger, Christian |d 1977- |e VerfasserIn |0 (DE-588)130275913 |0 (DE-627)589450751 |0 (DE-576)301504105 |4 aut | |
| 700 | 1 | |a Horn, Dominik |d 1984- |e VerfasserIn |0 (DE-588)1036568628 |0 (DE-627)750560045 |0 (DE-576)384807445 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of Clinical Medicine |d Basel : MDPI, 2012 |g 12(2023), 20, Artikel-ID 6602, Seite 1-12 |h Online-Ressource |w (DE-627)718632478 |w (DE-600)2662592-1 |w (DE-576)365782718 |x 2077-0383 |7 nnas |a Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma a prospective multi-center study |
| 773 | 1 | 8 | |g volume:12 |g year:2023 |g number:20 |g elocationid:6602 |g pages:1-12 |g extent:12 |a Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma a prospective multi-center study |
| 856 | 4 | 0 | |u https://doi.org/10.3390/jcm12206602 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2077-0383/12/20/6602 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231129 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1036568628 |a Horn, Dominik |m 1036568628:Horn, Dominik |d 50000 |e 50000PH1036568628 |k 0/50000/ |p 10 |y j | ||
| 998 | |g 130275913 |a Freudlsperger, Christian |m 130275913:Freudlsperger, Christian |d 910000 |d 910800 |d 50000 |e 910000PF130275913 |e 910800PF130275913 |e 50000PF130275913 |k 0/910000/ |k 1/910000/910800/ |k 0/50000/ |p 9 | ||
| 998 | |g 1032524456 |a Hoffmann, Jürgen |m 1032524456:Hoffmann, Jürgen |d 910000 |d 910800 |e 910000PH1032524456 |e 910800PH1032524456 |k 0/910000/ |k 1/910000/910800/ |p 8 | ||
| 998 | |g 132967367 |a Engel, Michael |m 132967367:Engel, Michael |d 910000 |d 910800 |d 50000 |e 910000PE132967367 |e 910800PE132967367 |e 50000PE132967367 |k 0/910000/ |k 1/910000/910800/ |k 0/50000/ |p 7 | ||
| 998 | |g 1064833276 |a Ristow, Oliver |m 1064833276:Ristow, Oliver |d 910000 |d 910800 |d 50000 |e 910000PR1064833276 |e 910800PR1064833276 |e 50000PR1064833276 |k 0/910000/ |k 1/910000/910800/ |k 0/50000/ |p 6 | ||
| 998 | |g 128789972 |a Freier, Kolja |m 128789972:Freier, Kolja |d 50000 |e 50000PF128789972 |k 0/50000/ |p 5 | ||
| 998 | |g 1136095136 |a Rückschloß, Thomas |m 1136095136:Rückschloß, Thomas |d 910000 |d 910800 |e 910000PR1136095136 |e 910800PR1136095136 |k 0/910000/ |k 1/910000/910800/ |p 4 | ||
| 998 | |g 1306960894 |a Awounvo Awounvo, Junior Sinclair |m 1306960894:Awounvo Awounvo, Junior Sinclair |d 910000 |d 911800 |e 910000PA1306960894 |e 911800PA1306960894 |k 0/910000/ |k 1/910000/911800/ |p 3 | ||
| 998 | |g 1048605442 |a Moratin, Julius |m 1048605442:Moratin, Julius |d 910000 |d 910800 |e 910000PM1048605442 |e 910800PM1048605442 |k 0/910000/ |k 1/910000/910800/ |p 2 | ||
| 998 | |g 1075611253 |a Zittel, Sven |m 1075611253:Zittel, Sven |d 910000 |d 910800 |e 910000PZ1075611253 |e 910800PZ1075611253 |k 0/910000/ |k 1/910000/910800/ |p 1 |x j | ||
| 999 | |a KXP-PPN1871573947 |e 4421674486 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"18 October 2023"}],"id":{"eki":["1871573947"],"doi":["10.3390/jcm12206602"]},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Journal of Clinical Medicine","title":"Journal of Clinical Medicine","subtitle":"open access journal"}],"part":{"volume":"12","pages":"1-12","text":"12(2023), 20, Artikel-ID 6602, Seite 1-12","year":"2023","extent":"12","issue":"20"},"origin":[{"dateIssuedKey":"2012","publisher":"MDPI","dateIssuedDisp":"2012-","publisherPlace":"Basel"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["718632478"],"issn":["2077-0383"],"zdb":["2662592-1"]},"language":["eng"],"pubHistory":["1.2012 -"],"note":["Gesehen am 12.06.20"],"recId":"718632478","disp":"Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma a prospective multi-center studyJournal of Clinical Medicine"}],"physDesc":[{"extent":"12 S.","noteIll":"Illustrationen"}],"person":[{"role":"aut","given":"Sven","display":"Zittel, Sven","family":"Zittel"},{"role":"aut","family":"Moratin","display":"Moratin, Julius","given":"Julius"},{"role":"aut","display":"Awounvo Awounvo, Junior Sinclair","family":"Awounvo Awounvo","given":"Junior Sinclair"},{"display":"Rückschloß, Thomas","family":"Rückschloß","given":"Thomas","role":"aut"},{"role":"aut","given":"Kolja","family":"Freier","display":"Freier, Kolja"},{"display":"Ristow, Oliver","family":"Ristow","given":"Oliver","role":"aut"},{"given":"Michael","display":"Engel, Michael","family":"Engel","role":"aut"},{"given":"Jürgen","display":"Hoffmann, Jürgen","family":"Hoffmann","role":"aut"},{"role":"aut","family":"Freudlsperger","display":"Freudlsperger, Christian","given":"Christian"},{"family":"Horn","display":"Horn, Dominik","given":"Dominik","role":"aut"}],"title":[{"subtitle":"a prospective multi-center study","title":"Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma","title_sort":"Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma"}],"note":["Gesehen am 29.11.2023"],"recId":"1871573947","name":{"displayForm":["Sven Zittel, Julius Moratin, Sinclair Awounvo, Thomas Rückschloß, Kolja Freier, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Christian Freudlsperger and Dominik Horn"]}} | ||
| SRT | |a ZITTELSVENIMPACTOFSA1820 | ||