Buchumschlag

Immunolocalization of soluble guanylyl cyclase subunits in rat kidney

Stimulation of soluble guanylyl cyclase (SGC) by nitric oxide (NO) results in the generation of cyclic guanosine monophosphate (cGMP). We recently described expression of abundant nitric oxide synthase, the enzyme by which NO is generated froml-arginine, in macula densa cells of rat kidney at the pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Mundel, Peter (VerfasserIn) , Bachmann, Sebastian (VerfasserIn) , Kriz, Wilhelm (VerfasserIn) , Gambaryan, S. (VerfasserIn) , Koesling, D. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1995
In: Histochemistry and cell biology
Year: 1995, Jahrgang: 103, Heft: 1, Pages: 75-79
ISSN:1432-119X
DOI:10.1007/BF01464478
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF01464478
Volltext
Verfasserangaben:P. Mundel, S. Bachmann, W. Kriz, S. Gambaryan, D. Koesling

MARC

LEADER 00000caa a2200000 c 4500
001 1871682142
003 DE-627
005 20240311160320.0
007 cr uuu---uuuuu
008 231130s1995 xx |||||o 00| ||eng c
024 7 |a 10.1007/BF01464478  |2 doi 
035 |a (DE-627)1871682142 
035 |a (DE-599)KXP1871682142 
035 |a (OCoLC)1425892786 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Mundel, Peter  |e VerfasserIn  |0 (DE-588)1104518805  |0 (DE-627)861921275  |0 (DE-576)168963841  |4 aut 
245 1 0 |a Immunolocalization of soluble guanylyl cyclase subunits in rat kidney  |c P. Mundel, S. Bachmann, W. Kriz, S. Gambaryan, D. Koesling 
264 1 |c 1995 
300 |a 5 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 30.11.2023 
520 |a Stimulation of soluble guanylyl cyclase (SGC) by nitric oxide (NO) results in the generation of cyclic guanosine monophosphate (cGMP). We recently described expression of abundant nitric oxide synthase, the enzyme by which NO is generated froml-arginine, in macula densa cells of rat kidney at the protein and mRNA level. In the present study we looked for possible targets of NO in the kidney. By light and electron microscopy, we applied polyclonal antisera against four subunits (α1,α2, β1β2) of SGC in immunocytochemical studies of frozen sections of rat kidney. We demonstrate the presence of α1-subunit in glomerular podocytes and of β2-subunit in principal cells of the collecting duct. In both cell types a cytosolic localization was evident from ultrastructural analysis. Regarding the collecting duct, NO was shown by other authors to inhibit sodium reabsorption in cultured mouse cortical collecting duct principal cells. In podocytes NO may relax the contractile system of podocyte foot processes, the tone of which has been suggested to counteract the elastic distension of the capillary wall. 
650 4 |a Capillary Wall 
650 4 |a Guanosine 
650 4 |a Nitric Oxide 
650 4 |a Polyclonal Antiserum 
650 4 |a Principal Cell 
700 1 |a Bachmann, Sebastian  |e VerfasserIn  |0 (DE-588)1112676155  |0 (DE-627)866753087  |0 (DE-576)476715970  |4 aut 
700 1 |a Kriz, Wilhelm  |d 1936-  |e VerfasserIn  |0 (DE-588)172197570  |0 (DE-627)69711130X  |0 (DE-576)133067750  |4 aut 
700 1 |a Gambaryan, S.  |e VerfasserIn  |4 aut 
700 1 |a Koesling, D.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Histochemistry and cell biology  |d Berlin : Springer, 1995  |g 103(1995), 1, Seite 75-79  |h Online-Ressource  |w (DE-627)235503568  |w (DE-600)1398345-3  |w (DE-576)061936065  |x 1432-119X  |7 nnas  |a Immunolocalization of soluble guanylyl cyclase subunits in rat kidney 
773 1 8 |g volume:103  |g year:1995  |g number:1  |g pages:75-79  |g extent:5  |a Immunolocalization of soluble guanylyl cyclase subunits in rat kidney 
856 4 0 |u https://doi.org/10.1007/BF01464478  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20231130 
994 |a 1995 
998 |g 172197570  |a Kriz, Wilhelm  |m 172197570:Kriz, Wilhelm  |d 50000  |d 53100  |e 50000PK172197570  |e 53100PK172197570  |k 0/50000/  |k 1/50000/53100/  |p 3 
998 |g 1112676155  |a Bachmann, Sebastian  |m 1112676155:Bachmann, Sebastian  |d 50000  |d 53100  |e 50000PB1112676155  |e 53100PB1112676155  |k 0/50000/  |k 1/50000/53100/  |p 2 
998 |g 1104518805  |a Mundel, Peter  |m 1104518805:Mundel, Peter  |d 50000  |d 53100  |e 50000PM1104518805  |e 53100PM1104518805  |k 0/50000/  |k 1/50000/53100/  |p 1  |x j 
999 |a KXP-PPN1871682142  |e 4422229508 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"recId":"1871682142","note":["Gesehen am 30.11.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Peter","family":"Mundel","role":"aut","display":"Mundel, Peter","roleDisplay":"VerfasserIn"},{"given":"Sebastian","family":"Bachmann","role":"aut","display":"Bachmann, Sebastian","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kriz, Wilhelm","given":"Wilhelm","family":"Kriz"},{"roleDisplay":"VerfasserIn","display":"Gambaryan, S.","role":"aut","family":"Gambaryan","given":"S."},{"given":"D.","family":"Koesling","role":"aut","display":"Koesling, D.","roleDisplay":"VerfasserIn"}],"title":[{"title":"Immunolocalization of soluble guanylyl cyclase subunits in rat kidney","title_sort":"Immunolocalization of soluble guanylyl cyclase subunits in rat kidney"}],"relHost":[{"title":[{"title_sort":"Histochemistry and cell biology","title":"Histochemistry and cell biology","subtitle":"official journal of the Society for Histochemistry"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 06.02.25","Fortsetzung der Druck-Ausgabe"],"disp":"Immunolocalization of soluble guanylyl cyclase subunits in rat kidneyHistochemistry and cell biology","language":["eng"],"recId":"235503568","pubHistory":["Volume 103, issue 1 (January 1995)-"],"part":{"text":"103(1995), 1, Seite 75-79","volume":"103","extent":"5","year":"1995","issue":"1","pages":"75-79"},"origin":[{"publisherPlace":"Berlin ; Heidelberg","dateIssuedDisp":"1995-","publisher":"Springer","dateIssuedKey":"1995"}],"id":{"zdb":["1398345-3"],"eki":["235503568"],"issn":["1432-119X"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"5 S."}],"name":{"displayForm":["P. Mundel, S. Bachmann, W. Kriz, S. Gambaryan, D. Koesling"]},"id":{"doi":["10.1007/BF01464478"],"eki":["1871682142"]},"origin":[{"dateIssuedKey":"1995","dateIssuedDisp":"1995"}]} 
SRT |a MUNDELPETEIMMUNOLOCA1995 

Ähnliche Einträge