WD40 proteins propel cellular networks
Recent findings indicate that WD40 domains play central roles in biological processes by acting as hubs in cellular networks; however, they have been studied less intensely than other common domains, such as the kinase, PDZ or SH3 domains. As suggested by various interactome studies, they are among...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2010
|
| In: |
Trends in biochemical sciences
Year: 2010, Jahrgang: 35, Heft: 10, Pages: 565-574 |
| ISSN: | 1362-4326 |
| DOI: | 10.1016/j.tibs.2010.04.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tibs.2010.04.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0968000410000721 |
| Verfasserangaben: | Christian U. Stirnimann, Evangelia Petsalaki, Robert B. Russell and Christoph W. Müller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1872039197 | ||
| 003 | DE-627 | ||
| 005 | 20240311120856.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231205s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.tibs.2010.04.003 |2 doi | |
| 035 | |a (DE-627)1872039197 | ||
| 035 | |a (DE-599)KXP1872039197 | ||
| 035 | |a (OCoLC)1425872622 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Stirnimann, Christian Urs |d 1978- |e VerfasserIn |0 (DE-588)133995917 |0 (DE-627)691997187 |0 (DE-576)30024276X |4 aut | |
| 245 | 1 | 0 | |a WD40 proteins propel cellular networks |c Christian U. Stirnimann, Evangelia Petsalaki, Robert B. Russell and Christoph W. Müller |
| 246 | 3 | 3 | |a WD forty proteins propel cellular networks |
| 264 | 1 | |c October 2010 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.12.2023 | ||
| 520 | |a Recent findings indicate that WD40 domains play central roles in biological processes by acting as hubs in cellular networks; however, they have been studied less intensely than other common domains, such as the kinase, PDZ or SH3 domains. As suggested by various interactome studies, they are among the most promiscuous interactors. Structural studies suggest that this property stems from their ability, as scaffolds, to interact with diverse proteins, peptides or nucleic acids using multiple surfaces or modes of interaction. A general scaffolding role is supported by the fact that no WD40 domain has been found with intrinsic enzymatic activity despite often being part of large molecular machines. We discuss the WD40 domain distributions in protein networks and structures of WD40-containing assemblies to demonstrate their versatility in mediating critical cellular functions. | ||
| 700 | 1 | |a Petsalaki, Evangelia |d 1983- |e VerfasserIn |0 (DE-588)139010742 |0 (DE-627)703180142 |0 (DE-576)309378281 |4 aut | |
| 700 | 1 | |a Russell, Robert B. |e VerfasserIn |0 (DE-588)173751091 |0 (DE-627)698656334 |0 (DE-576)134591755 |4 aut | |
| 700 | 1 | |a Müller, Christoph W. |d 1960- |e VerfasserIn |0 (DE-588)1135746710 |0 (DE-627)890784477 |0 (DE-576)167743481 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Trends in biochemical sciences |d Amsterdam [u.a.] : Elsevier Science, 1976 |g 35(2010), 10, Seite 565-574 |h Online-Ressource |w (DE-627)306593068 |w (DE-600)1498901-3 |w (DE-576)094113513 |x 1362-4326 |7 nnas |a WD40 proteins propel cellular networks |
| 773 | 1 | 8 | |g volume:35 |g year:2010 |g number:10 |g pages:565-574 |g extent:10 |a WD40 proteins propel cellular networks |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.tibs.2010.04.003 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0968000410000721 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231205 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1135746710 |a Müller, Christoph W. |m 1135746710:Müller, Christoph W. |d 700000 |d 718000 |e 700000PM1135746710 |e 718000PM1135746710 |k 0/700000/ |k 1/700000/718000/ |p 4 |y j | ||
| 998 | |g 173751091 |a Russell, Robert B. |m 173751091:Russell, Robert B. |d 700000 |d 711000 |e 700000PR173751091 |e 711000PR173751091 |k 0/700000/ |k 1/700000/711000/ |p 3 | ||
| 999 | |a KXP-PPN1872039197 |e 4426296110 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"October 2010"}],"recId":"1872039197","titleAlt":[{"title":"WD forty proteins propel cellular networks"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1872039197"],"doi":["10.1016/j.tibs.2010.04.003"]},"note":["Gesehen am 05.12.2023"],"name":{"displayForm":["Christian U. Stirnimann, Evangelia Petsalaki, Robert B. Russell and Christoph W. Müller"]},"title":[{"title_sort":"WD40 proteins propel cellular networks","title":"WD40 proteins propel cellular networks"}],"relHost":[{"recId":"306593068","titleAlt":[{"title":"TIBS"}],"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1976","dateIssuedDisp":"1976-","publisher":"Elsevier Science"}],"id":{"zdb":["1498901-3"],"issn":["1362-4326"],"eki":["306593068"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1976 -"],"part":{"extent":"10","year":"2010","volume":"35","text":"35(2010), 10, Seite 565-574","issue":"10","pages":"565-574"},"name":{"displayForm":["publ. by the International Union of Biochemistry and Molecular Biology and Elsevier Trends Journals"]},"note":["Gesehen am 28.05.20"],"disp":"WD40 proteins propel cellular networksTrends in biochemical sciences","corporate":[{"display":"International Union of Biochemistry and Molecular Biology","role":"isb"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Trends in biochemical sciences","title":"Trends in biochemical sciences","subtitle":"TIBS"}]}],"physDesc":[{"extent":"10 S."}],"person":[{"given":"Christian Urs","family":"Stirnimann","role":"aut","display":"Stirnimann, Christian Urs"},{"given":"Evangelia","family":"Petsalaki","role":"aut","display":"Petsalaki, Evangelia"},{"display":"Russell, Robert B.","role":"aut","family":"Russell","given":"Robert B."},{"role":"aut","display":"Müller, Christoph W.","given":"Christoph W.","family":"Müller"}],"language":["eng"]} | ||
| SRT | |a STIRNIMANNWD40PROTEI2010 | ||