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Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years

In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to dementia-related biomarkers should be explored. Therefore, we examined t...

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Hauptverfasser: Stocker, Hannah (VerfasserIn) , Trares, Kira (VerfasserIn) , Beyer, Léon (VerfasserIn) , Perna, Laura (VerfasserIn) , Rujescu, Dan (VerfasserIn) , Holleczek, Bernd (VerfasserIn) , Beyreuther, Konrad (VerfasserIn) , Gerwert, Klaus (VerfasserIn) , Schöttker, Ben (VerfasserIn) , Brenner, Hermann (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 July 2023
In: Alzheimer's research & therapy
Year: 2023, Jahrgang: 15, Pages: 1-9
ISSN:1758-9193
DOI:10.1186/s13195-023-01277-8
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13195-023-01277-8
Verlag, kostenfrei, Volltext: https://alzres.biomedcentral.com/articles/10.1186/s13195-023-01277-8
Volltext
Verfasserangaben:Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker and Hermann Brenner
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Zusammenfassung:In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to dementia-related biomarkers should be explored. Therefore, we examined the association of APOE4 and various PRSs, based on training sets that utilized differing AD definitions, with incident AD and all-cause dementia (ACD) within 17 years, and with levels of phosphorylated tau181 (P-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) in blood. Secondarily, effect modification by APOE4 status and sex was examined.
Beschreibung:Gesehen am 07.12.2023
Beschreibung:Online Resource
ISSN:1758-9193
DOI:10.1186/s13195-023-01277-8

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