Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Background: Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the International...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 October 2023
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| In: |
Discover oncology
Year: 2023, Volume: 14, Pages: 1-10 |
| ISSN: | 2730-6011 |
| DOI: | 10.1007/s12672-023-00799-9 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12672-023-00799-9
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| Author Notes: | Karla Rubio, Jason M. Müller, Aditi Mehta, Iris Watermann, Till Olchers, Ina Koch, Sabine Wessels, Marc A. Schneider, Tania Araujo-Ramos, Indrabahadur Singh, Christian Kugler, Mircea Gabriel Stoleriu, Mark Kriegsmann, Martin Eichhorn, Thomas Muley, Olivia M. Merkel, Thomas Braun, Ole Ammerpohl, Martin Reck, Achim Tresch, Guillermo Barreto |
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| 245 | 1 | 0 | |a Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score |c Karla Rubio, Jason M. Müller, Aditi Mehta, Iris Watermann, Till Olchers, Ina Koch, Sabine Wessels, Marc A. Schneider, Tania Araujo-Ramos, Indrabahadur Singh, Christian Kugler, Mircea Gabriel Stoleriu, Mark Kriegsmann, Martin Eichhorn, Thomas Muley, Olivia M. Merkel, Thomas Braun, Ole Ammerpohl, Martin Reck, Achim Tresch, Guillermo Barreto |
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| 520 | |a Background: Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the International Association for the Study of Lung Cancer (IASLC) database indicates that early diagnosis is significantly associated with favorable outcome. However, since symptoms of LC at early stages are unspecific and resemble those of benign pathologies, current diagnostic approaches are mostly initiated at advanced LC stages. Methods: We developed a LC diagnosis test based on the analysis of distinct RNA isoforms expressed from the GATA6 and NKX2-1 gene loci, which are detected in exhaled breath condensates (EBCs). Levels of these transcript isoforms in EBCs were combined to calculate a diagnostic score (the LC score). In the present study, we aimed to confirm the applicability of the LC score for the diagnosis of early stage LC under clinical settings. Thus, we evaluated EBCs from patients with early stage, resectable non-small cell lung cancer (NSCLC), who were prospectively enrolled in the EMoLung study at three sites in Germany. Results: LC score-based classification of EBCs confirmed its performance under clinical conditions, achieving a sensitivity of 95.7%, 91.3% and 84.6% for LC detection at stages I, II and III, respectively. Conclusions: The LC score is an accurate and non-invasive option for early LC diagnosis and a valuable complement to LC screening procedures based on computed tomography. | ||
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