Oxytocin receptor expression patterns in the human brain across development
Oxytocin plays a vital role in social behavior and homeostatic processes, with animal models indicating that oxytocin receptor (OXTR) expression patterns in the brain influence behavior and physiology. However, the developmental trajectory of OXTR gene expression is unclear. By analyzing gene expres...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 March 2022
|
| In: |
Neuropsychopharmacology
Year: 2022, Jahrgang: 47, Heft: 8, Pages: 1550-1560 |
| ISSN: | 1740-634X |
| DOI: | 10.1038/s41386-022-01305-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41386-022-01305-5 Verlag, lizenzpflichtig, Volltext: http://www.nature.com/articles/s41386-022-01305-5 
|
| Verfasserangaben: | Jaroslav Rokicki, Tobias Kaufmann, Ann-Marie G. de Lange, Dennis van der Meer, Shahram Bahrami, Alina M. Sartorius, Unn K. Haukvik, Nils Eiel Steen, Emanuel Schwarz, Dan J. Stein, Terje Nærland, Ole A. Andreassen, Lars T. Westlye, and Daniel S. Quintana |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1873119380 | ||
| 003 | DE-627 | ||
| 005 | 20240307081111.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231212s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41386-022-01305-5 |2 doi | |
| 035 | |a (DE-627)1873119380 | ||
| 035 | |a (DE-599)KXP1873119380 | ||
| 035 | |a (OCoLC)1425216076 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rokicki, Jaroslav |e VerfasserIn |0 (DE-588)1238054455 |0 (DE-627)1765258936 |4 aut | |
| 245 | 1 | 0 | |a Oxytocin receptor expression patterns in the human brain across development |c Jaroslav Rokicki, Tobias Kaufmann, Ann-Marie G. de Lange, Dennis van der Meer, Shahram Bahrami, Alina M. Sartorius, Unn K. Haukvik, Nils Eiel Steen, Emanuel Schwarz, Dan J. Stein, Terje Nærland, Ole A. Andreassen, Lars T. Westlye, and Daniel S. Quintana |
| 264 | 1 | |c 28 March 2022 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.12.2023 | ||
| 520 | |a Oxytocin plays a vital role in social behavior and homeostatic processes, with animal models indicating that oxytocin receptor (OXTR) expression patterns in the brain influence behavior and physiology. However, the developmental trajectory of OXTR gene expression is unclear. By analyzing gene expression data in human post-mortem brain samples, from the prenatal period to late adulthood, we demonstrate distinct patterns of OXTR gene expression in the developing brain, with increasing OXTR expression along the course of the prenatal period culminating in a peak during early childhood. This early life OXTR expression peak pattern appears slightly earlier in a comparative macaque sample, which is consistent with the relative immaturity of the human brain during early life compared to macaques. We also show that a network of genes with strong spatiotemporal couplings with OXTR is enriched in several psychiatric illness and body composition phenotypes. Taken together, these results demonstrate that oxytocin signaling plays an important role in a diverse set of psychological and somatic processes across the lifespan. | ||
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Genetics of the nervous system | |
| 700 | 1 | |a Kaufmann, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a de Lange, Ann-Marie G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a van der Meer, Dennis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bahrami, Shahram |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sartorius, Alina M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haukvik, Unn K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steen, Nils Eiel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwarz, Emanuel |e VerfasserIn |0 (DE-588)1055051260 |0 (DE-627)792581040 |0 (DE-576)411121596 |4 aut | |
| 700 | 1 | |a Stein, Dan J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nærland, Terje |e VerfasserIn |4 aut | |
| 700 | 1 | |a Andreassen, Ole A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Westlye, Lars T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Quintana, Daniel S. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuropsychopharmacology |d London : Springer Nature, 1993 |g 47(2022), 8, Seite 1550-1560 |h Online-Ressource |w (DE-627)320469190 |w (DE-600)2008300-2 |w (DE-576)096188707 |x 1740-634X |7 nnas |a Oxytocin receptor expression patterns in the human brain across development |
| 773 | 1 | 8 | |g volume:47 |g year:2022 |g number:8 |g pages:1550-1560 |g extent:11 |a Oxytocin receptor expression patterns in the human brain across development |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41386-022-01305-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.nature.com/articles/s41386-022-01305-5 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231212 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1055051260 |a Schwarz, Emanuel |m 1055051260:Schwarz, Emanuel |d 60000 |e 60000PS1055051260 |k 0/60000/ |p 9 | ||
| 999 | |a KXP-PPN1873119380 |e 4431153144 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1038/s41386-022-01305-5"],"eki":["1873119380"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"28 March 2022"}],"person":[{"display":"Rokicki, Jaroslav","family":"Rokicki","role":"aut","given":"Jaroslav"},{"display":"Kaufmann, Tobias","role":"aut","given":"Tobias","family":"Kaufmann"},{"given":"Ann-Marie G.","role":"aut","family":"de Lange","display":"de Lange, Ann-Marie G."},{"display":"van der Meer, Dennis","family":"van der Meer","given":"Dennis","role":"aut"},{"display":"Bahrami, Shahram","role":"aut","given":"Shahram","family":"Bahrami"},{"display":"Sartorius, Alina M.","given":"Alina M.","role":"aut","family":"Sartorius"},{"display":"Haukvik, Unn K.","given":"Unn K.","role":"aut","family":"Haukvik"},{"display":"Steen, Nils Eiel","role":"aut","given":"Nils Eiel","family":"Steen"},{"display":"Schwarz, Emanuel","given":"Emanuel","role":"aut","family":"Schwarz"},{"family":"Stein","given":"Dan J.","role":"aut","display":"Stein, Dan J."},{"family":"Nærland","given":"Terje","role":"aut","display":"Nærland, Terje"},{"given":"Ole A.","role":"aut","family":"Andreassen","display":"Andreassen, Ole A."},{"display":"Westlye, Lars T.","given":"Lars T.","role":"aut","family":"Westlye"},{"role":"aut","given":"Daniel S.","family":"Quintana","display":"Quintana, Daniel S."}],"title":[{"title":"Oxytocin receptor expression patterns in the human brain across development","title_sort":"Oxytocin receptor expression patterns in the human brain across development"}],"note":["Gesehen am 12.12.2023"],"recId":"1873119380","language":["eng"],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"320469190","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"issue":"8","volume":"47","pages":"1550-1560","extent":"11","text":"47(2022), 8, Seite 1550-1560","year":"2022"},"id":{"eki":["320469190"],"issn":["1740-634X"],"zdb":["2008300-2"]},"origin":[{"dateIssuedKey":"1993","publisherPlace":"London ; Amsterdam [u.a.] ; London","dateIssuedDisp":"1993-","publisher":"Springer Nature ; Elsevier Science ; Nature Publ. Group"}],"pubHistory":["Nachgewiesen 8.1993 -"],"title":[{"title":"Neuropsychopharmacology","title_sort":"Neuropsychopharmacology","subtitle":"official publication of the American College of Neuropsychopharmacology"}],"note":["Ungezählte Beil.: Supplement"],"disp":"Oxytocin receptor expression patterns in the human brain across developmentNeuropsychopharmacology"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Jaroslav Rokicki, Tobias Kaufmann, Ann-Marie G. de Lange, Dennis van der Meer, Shahram Bahrami, Alina M. Sartorius, Unn K. Haukvik, Nils Eiel Steen, Emanuel Schwarz, Dan J. Stein, Terje Nærland, Ole A. Andreassen, Lars T. Westlye, and Daniel S. Quintana"]},"physDesc":[{"extent":"11 S.","noteIll":"Illustrationen"}]} | ||
| SRT | |a ROKICKIJAROXYTOCINRE2820 | ||