Cover Image

Gallbladder cancer risk and indigenous South American Mapuche ancestry: instrumental variable analysis using ancestry-informative markers

A strong association between the proportion of indigenous South American Mapuche ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest indigenous people in Chile. We set out...

Full description

Saved in:
Bibliographic Details
Main Authors: Zollner, Linda (Author) , Boekstegers, Felix (Author) , Barahona Ponce, Carol (Author) , Scherer, Dominique (Author) , Marcelain, Katherine (Author) , Gárate-Calderón, Valentina (Author) , Waldenberger, Melanie (Author) , Morales, Erik (Author) , Rojas, Armando (Author) , Munoz, César (Author) , Retamales, Javier (Author) , De Toro, Gonzalo (Author) , Kortmann, Allan Vera (Author) , Barajas, Olga (Author) , Rivera, María Teresa (Author) , Cortés, Analía (Author) , Loader, Denisse (Author) , Saavedra, Javiera (Author) , Gutiérrez, Lorena (Author) , Ortega, Alejandro (Author) , Bertrán, Maria Enriqueta (Author) , Bartolotti, Leonardo (Author) , Gabler, Fernando (Author) , Campos, Mónica (Author) , Alvarado, Juan (Author) , Moisán, Fabricio (Author) , Spencer, Loreto (Author) , Nervi, Bruno (Author) , Carvajal, Daniel (Author) , Losada, Héctor (Author) , Almau, Mauricio (Author) , Fernández, Plinio (Author) , Olloquequi, Jordi (Author) , Carter, Alice R. (Author) , Miquel Poblete, Juan Francisco (Author) , Bustos, Bernabe Ignacio (Author) , Fuentes Guajardo, Macarena (Author) , Gonzalez-Jose, Rolando (Author) , Bortolini, Maria Cátira (Author) , Acuña-Alonzo, Victor (Author) , Gallo, Carla (Author) , Ruiz Linares, Andres (Author) , Rothhammer, Francisco (Author) , Lorenzo Bermejo, Justo (Author)
Format: Article (Journal)
Language:English
Published: 9 August 2023
In: Cancers
Year: 2023, Volume: 15, Issue: 16, Pages: 1-17
ISSN:2072-6694
DOI:10.3390/cancers15164033
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers15164033
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/15/16/4033
Get full text
Author Notes:Linda Zollner, Felix Boekstegers, Carol Barahona Ponce, Dominique Scherer, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo De Toro, Allan Vera Kortmann, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Bertrán, Leonardo Bartolotti, Fernando Gabler, Mónica Campos, Juan Alvarado, Fabricio Moisán, Loreto Spencer, Bruno Nervi, Daniel Carvajal, Héctor Losada, Mauricio Almau, Plinio Fernández, Jordi Olloquequi, Alice R. Carter, Juan Francisco Miquel Poblete, Bernabe Ignacio Bustos, Macarena Fuentes Guajardo, Rolando Gonzalez-Jose, Maria Cátira Bortolini, Victor Acuña-Alonzo, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer and Justo Lorenzo Bermejo

MARC

LEADER 00000caa a2200000 c 4500
001 1873120079
003 DE-627
005 20240307033606.0
007 cr uuu---uuuuu
008 231212s2023 xx |||||o 00| ||eng c
024 7 |a 10.3390/cancers15164033  |2 doi 
035 |a (DE-627)1873120079 
035 |a (DE-599)KXP1873120079 
035 |a (OCoLC)1425208366 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Zollner, Linda  |d 1994-  |e VerfasserIn  |0 (DE-588)131306582X  |0 (DE-627)1873121369  |4 aut 
245 1 0 |a Gallbladder cancer risk and indigenous South American Mapuche ancestry  |b instrumental variable analysis using ancestry-informative markers  |c Linda Zollner, Felix Boekstegers, Carol Barahona Ponce, Dominique Scherer, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo De Toro, Allan Vera Kortmann, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Bertrán, Leonardo Bartolotti, Fernando Gabler, Mónica Campos, Juan Alvarado, Fabricio Moisán, Loreto Spencer, Bruno Nervi, Daniel Carvajal, Héctor Losada, Mauricio Almau, Plinio Fernández, Jordi Olloquequi, Alice R. Carter, Juan Francisco Miquel Poblete, Bernabe Ignacio Bustos, Macarena Fuentes Guajardo, Rolando Gonzalez-Jose, Maria Cátira Bortolini, Victor Acuña-Alonzo, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer and Justo Lorenzo Bermejo 
264 1 |c 9 August 2023 
300 |b Illustrationen 
300 |a 17 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online veröffentlicht: 9. August 2023 
500 |a Gesehen am 12.12.2023 
520 |a A strong association between the proportion of indigenous South American Mapuche ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest indigenous people in Chile. We set out to assess the confounding-free effect of the individual proportion of Mapuche ancestry on GBC risk and to investigate the mediating effects of gallstone disease and body mass index (BMI) on this association. Genetic markers of Mapuche ancestry were selected based on the informativeness for assignment measure, and then used as instrumental variables in two-sample Mendelian randomization analyses and complementary sensitivity analyses. Results suggested a putatively causal effect of Mapuche ancestry on GBC risk (inverse variance-weighted (IVW) risk increase of 0.8% per 1% increase in Mapuche ancestry proportion, 95% CI 0.4% to 1.2%, p = 6.7 × 10−5) and also on gallstone disease (3.6% IVW risk increase, 95% CI 3.1% to 4.0%), pointing to a mediating effect of gallstones on the association between Mapuche ancestry and GBC. In contrast, the proportion of Mapuche ancestry showed a negative effect on BMI (IVW estimate −0.006 kg/m2, 95% CI −0.009 to −0.003). The results presented here may have significant implications for GBC prevention and are important for future admixture mapping studies. Given that the association between the individual proportion of Mapuche ancestry and GBC risk previously noted in observational studies appears to be free of confounding, primary and secondary prevention strategies that consider genetic ancestry could be particularly efficient. 
650 4 |a ancestry-informative markers 
650 4 |a causal inference 
650 4 |a gallbladder cancer 
650 4 |a gallstone disease 
650 4 |a genetic admixture 
650 4 |a indigenous South American Mapuche ancestry 
650 4 |a instrumental variables 
650 4 |a Mendelian randomization 
700 1 |a Boekstegers, Felix  |d 1986-  |e VerfasserIn  |0 (DE-588)1135579415  |0 (DE-627)890491380  |0 (DE-576)489823823  |4 aut 
700 1 |a Barahona Ponce, Carol  |d 1987-  |e VerfasserIn  |0 (DE-588)1135580170  |0 (DE-627)890493081  |0 (DE-576)48982594X  |4 aut 
700 1 |a Scherer, Dominique  |d 1978-  |e VerfasserIn  |0 (DE-588)140126090  |0 (DE-627)616036647  |0 (DE-576)314697233  |4 aut 
700 1 |a Marcelain, Katherine  |e VerfasserIn  |4 aut 
700 1 |a Gárate-Calderón, Valentina  |e VerfasserIn  |4 aut 
700 1 |a Waldenberger, Melanie  |e VerfasserIn  |4 aut 
700 1 |a Morales, Erik  |e VerfasserIn  |4 aut 
700 1 |a Rojas, Armando  |e VerfasserIn  |4 aut 
700 1 |a Munoz, César  |e VerfasserIn  |4 aut 
700 1 |a Retamales, Javier  |e VerfasserIn  |4 aut 
700 1 |a De Toro, Gonzalo  |e VerfasserIn  |4 aut 
700 1 |a Kortmann, Allan Vera  |e VerfasserIn  |4 aut 
700 1 |a Barajas, Olga  |e VerfasserIn  |4 aut 
700 1 |a Rivera, María Teresa  |e VerfasserIn  |4 aut 
700 1 |a Cortés, Analía  |e VerfasserIn  |4 aut 
700 1 |a Loader, Denisse  |e VerfasserIn  |4 aut 
700 1 |a Saavedra, Javiera  |e VerfasserIn  |4 aut 
700 1 |a Gutiérrez, Lorena  |e VerfasserIn  |4 aut 
700 1 |a Ortega, Alejandro  |e VerfasserIn  |4 aut 
700 1 |a Bertrán, Maria Enriqueta  |e VerfasserIn  |4 aut 
700 1 |a Bartolotti, Leonardo  |e VerfasserIn  |4 aut 
700 1 |a Gabler, Fernando  |e VerfasserIn  |4 aut 
700 1 |a Campos, Mónica  |e VerfasserIn  |4 aut 
700 1 |a Alvarado, Juan  |e VerfasserIn  |4 aut 
700 1 |a Moisán, Fabricio  |e VerfasserIn  |4 aut 
700 1 |a Spencer, Loreto  |e VerfasserIn  |4 aut 
700 1 |a Nervi, Bruno  |e VerfasserIn  |4 aut 
700 1 |a Carvajal, Daniel  |e VerfasserIn  |4 aut 
700 1 |a Losada, Héctor  |e VerfasserIn  |4 aut 
700 1 |a Almau, Mauricio  |e VerfasserIn  |4 aut 
700 1 |a Fernández, Plinio  |e VerfasserIn  |4 aut 
700 1 |a Olloquequi, Jordi  |e VerfasserIn  |4 aut 
700 1 |a Carter, Alice R.  |e VerfasserIn  |4 aut 
700 1 |a Miquel Poblete, Juan Francisco  |e VerfasserIn  |4 aut 
700 1 |a Bustos, Bernabe Ignacio  |e VerfasserIn  |4 aut 
700 1 |a Fuentes Guajardo, Macarena  |e VerfasserIn  |4 aut 
700 1 |a Gonzalez-Jose, Rolando  |e VerfasserIn  |4 aut 
700 1 |a Bortolini, Maria Cátira  |e VerfasserIn  |4 aut 
700 1 |a Acuña-Alonzo, Victor  |e VerfasserIn  |4 aut 
700 1 |a Gallo, Carla  |e VerfasserIn  |4 aut 
700 1 |a Ruiz Linares, Andres  |e VerfasserIn  |4 aut 
700 1 |a Rothhammer, Francisco  |e VerfasserIn  |4 aut 
700 1 |a Lorenzo Bermejo, Justo  |d 1972-  |e VerfasserIn  |0 (DE-588)124754619  |0 (DE-627)706705572  |0 (DE-576)294483632  |4 aut 
773 0 8 |i Enthalten in  |t Cancers  |d Basel : MDPI, 2009  |g 15(2023), 16, Artikel-ID 4033, Seite 1-17  |h Online-Ressource  |w (DE-627)614095670  |w (DE-600)2527080-1  |w (DE-576)313958548  |x 2072-6694  |7 nnas  |a Gallbladder cancer risk and indigenous South American Mapuche ancestry instrumental variable analysis using ancestry-informative markers 
773 1 8 |g volume:15  |g year:2023  |g number:16  |g elocationid:4033  |g pages:1-17  |g extent:17  |a Gallbladder cancer risk and indigenous South American Mapuche ancestry instrumental variable analysis using ancestry-informative markers 
856 4 0 |u https://doi.org/10.3390/cancers15164033  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.mdpi.com/2072-6694/15/16/4033  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20231212 
993 |a Article 
994 |a 2023 
998 |g 124754619  |a Lorenzo Bermejo, Justo  |m 124754619:Lorenzo Bermejo, Justo  |d 910000  |d 911800  |d 50000  |e 910000PL124754619  |e 911800PL124754619  |e 50000PL124754619  |k 0/910000/  |k 1/910000/911800/  |k 0/50000/  |p 44  |y j 
998 |g 140126090  |a Scherer, Dominique  |m 140126090:Scherer, Dominique  |d 910000  |d 911800  |e 910000PS140126090  |e 911800PS140126090  |k 0/910000/  |k 1/910000/911800/  |p 4 
998 |g 1135580170  |a Barahona Ponce, Carol  |m 1135580170:Barahona Ponce, Carol  |d 910000  |d 911800  |e 910000PB1135580170  |e 911800PB1135580170  |k 0/910000/  |k 1/910000/911800/  |p 3 
998 |g 1135579415  |a Boekstegers, Felix  |m 1135579415:Boekstegers, Felix  |p 2 
998 |g 131306582X  |a Zollner, Linda  |m 131306582X:Zollner, Linda  |d 50000  |e 50000PZ131306582X  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1873120079  |e 4431177884 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"id":{"eki":["1873120079"],"doi":["10.3390/cancers15164033"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"9 August 2023"}],"physDesc":[{"extent":"17 S.","noteIll":"Illustrationen"}],"person":[{"given":"Linda","display":"Zollner, Linda","family":"Zollner","role":"aut"},{"role":"aut","family":"Boekstegers","display":"Boekstegers, Felix","given":"Felix"},{"family":"Barahona Ponce","display":"Barahona Ponce, Carol","given":"Carol","role":"aut"},{"family":"Scherer","display":"Scherer, Dominique","given":"Dominique","role":"aut"},{"role":"aut","family":"Marcelain","display":"Marcelain, Katherine","given":"Katherine"},{"role":"aut","given":"Valentina","family":"Gárate-Calderón","display":"Gárate-Calderón, Valentina"},{"family":"Waldenberger","display":"Waldenberger, Melanie","given":"Melanie","role":"aut"},{"given":"Erik","display":"Morales, Erik","family":"Morales","role":"aut"},{"family":"Rojas","display":"Rojas, Armando","given":"Armando","role":"aut"},{"role":"aut","given":"César","family":"Munoz","display":"Munoz, César"},{"given":"Javier","family":"Retamales","display":"Retamales, Javier","role":"aut"},{"role":"aut","family":"De Toro","display":"De Toro, Gonzalo","given":"Gonzalo"},{"given":"Allan Vera","family":"Kortmann","display":"Kortmann, Allan Vera","role":"aut"},{"role":"aut","given":"Olga","display":"Barajas, Olga","family":"Barajas"},{"display":"Rivera, María Teresa","family":"Rivera","given":"María Teresa","role":"aut"},{"given":"Analía","family":"Cortés","display":"Cortés, Analía","role":"aut"},{"family":"Loader","display":"Loader, Denisse","given":"Denisse","role":"aut"},{"role":"aut","given":"Javiera","display":"Saavedra, Javiera","family":"Saavedra"},{"given":"Lorena","family":"Gutiérrez","display":"Gutiérrez, Lorena","role":"aut"},{"given":"Alejandro","family":"Ortega","display":"Ortega, Alejandro","role":"aut"},{"given":"Maria Enriqueta","display":"Bertrán, Maria Enriqueta","family":"Bertrán","role":"aut"},{"given":"Leonardo","family":"Bartolotti","display":"Bartolotti, Leonardo","role":"aut"},{"display":"Gabler, Fernando","family":"Gabler","given":"Fernando","role":"aut"},{"role":"aut","given":"Mónica","family":"Campos","display":"Campos, Mónica"},{"role":"aut","given":"Juan","display":"Alvarado, Juan","family":"Alvarado"},{"role":"aut","display":"Moisán, Fabricio","family":"Moisán","given":"Fabricio"},{"display":"Spencer, Loreto","family":"Spencer","given":"Loreto","role":"aut"},{"given":"Bruno","display":"Nervi, Bruno","family":"Nervi","role":"aut"},{"role":"aut","family":"Carvajal","display":"Carvajal, Daniel","given":"Daniel"},{"role":"aut","display":"Losada, Héctor","family":"Losada","given":"Héctor"},{"family":"Almau","display":"Almau, Mauricio","given":"Mauricio","role":"aut"},{"given":"Plinio","family":"Fernández","display":"Fernández, Plinio","role":"aut"},{"family":"Olloquequi","display":"Olloquequi, Jordi","given":"Jordi","role":"aut"},{"family":"Carter","display":"Carter, Alice R.","given":"Alice R.","role":"aut"},{"role":"aut","family":"Miquel Poblete","display":"Miquel Poblete, Juan Francisco","given":"Juan Francisco"},{"display":"Bustos, Bernabe Ignacio","family":"Bustos","given":"Bernabe Ignacio","role":"aut"},{"display":"Fuentes Guajardo, Macarena","family":"Fuentes Guajardo","given":"Macarena","role":"aut"},{"family":"Gonzalez-Jose","display":"Gonzalez-Jose, Rolando","given":"Rolando","role":"aut"},{"given":"Maria Cátira","display":"Bortolini, Maria Cátira","family":"Bortolini","role":"aut"},{"role":"aut","family":"Acuña-Alonzo","display":"Acuña-Alonzo, Victor","given":"Victor"},{"given":"Carla","family":"Gallo","display":"Gallo, Carla","role":"aut"},{"family":"Ruiz Linares","display":"Ruiz Linares, Andres","given":"Andres","role":"aut"},{"role":"aut","given":"Francisco","family":"Rothhammer","display":"Rothhammer, Francisco"},{"role":"aut","family":"Lorenzo Bermejo","display":"Lorenzo Bermejo, Justo","given":"Justo"}],"title":[{"subtitle":"instrumental variable analysis using ancestry-informative markers","title":"Gallbladder cancer risk and indigenous South American Mapuche ancestry","title_sort":"Gallbladder cancer risk and indigenous South American Mapuche ancestry"}],"relHost":[{"disp":"Gallbladder cancer risk and indigenous South American Mapuche ancestry instrumental variable analysis using ancestry-informative markersCancers","recId":"614095670","pubHistory":["1.2009 -"],"note":["Gesehen am 27.05.2020"],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"origin":[{"dateIssuedKey":"2009","publisher":"MDPI","dateIssuedDisp":"2009-","publisherPlace":"Basel"}],"id":{"zdb":["2527080-1"],"issn":["2072-6694"],"eki":["614095670"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"part":{"volume":"15","text":"15(2023), 16, Artikel-ID 4033, Seite 1-17","pages":"1-17","extent":"17","year":"2023","issue":"16"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Cancers","title":"Cancers"}]}],"name":{"displayForm":["Linda Zollner, Felix Boekstegers, Carol Barahona Ponce, Dominique Scherer, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo De Toro, Allan Vera Kortmann, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Bertrán, Leonardo Bartolotti, Fernando Gabler, Mónica Campos, Juan Alvarado, Fabricio Moisán, Loreto Spencer, Bruno Nervi, Daniel Carvajal, Héctor Losada, Mauricio Almau, Plinio Fernández, Jordi Olloquequi, Alice R. Carter, Juan Francisco Miquel Poblete, Bernabe Ignacio Bustos, Macarena Fuentes Guajardo, Rolando Gonzalez-Jose, Maria Cátira Bortolini, Victor Acuña-Alonzo, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer and Justo Lorenzo Bermejo"]},"recId":"1873120079","note":["Online veröffentlicht: 9. August 2023","Gesehen am 12.12.2023"]} 
SRT |a ZOLLNERLINGALLBLADDE9202 

Similar Items