HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function
Failures to produce neutralizing antibodies upon HIV‐1 infection result in part from B‐cell dysfunction due to unspecific B‐cell activation. How HIV‐1 affects antigen‐specific B‐cell functions remains elusive. Using an adoptive transfer mouse model and ex vivo HIV infection of human tonsil tissue, w...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 November 2020
|
| In: |
The EMBO journal
Year: 2020, Jahrgang: 39, Heft: 24, Pages: 1-18 |
| ISSN: | 1460-2075 |
| DOI: | 10.15252/embj.2020105594 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15252/embj.2020105594 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.15252/embj.2020105594 
|
| Verfasserangaben: | Sheetal Kaw, Swetha Ananth, Nikolaos Tsopoulidis, Katharina Morath, Bahar M Coban, Ralph Hohenberger, Olcay C Bulut, Florian Klein, Bettina Stolp & Oliver T Fackler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1876317736 | ||
| 003 | DE-627 | ||
| 005 | 20240307094006.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231218s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/embj.2020105594 |2 doi | |
| 035 | |a (DE-627)1876317736 | ||
| 035 | |a (DE-599)KXP1876317736 | ||
| 035 | |a (OCoLC)1295679884 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kaw, Sheetal |e VerfasserIn |0 (DE-588)1172738106 |0 (DE-627)1041379153 |0 (DE-576)514766859 |4 aut | |
| 245 | 1 | 0 | |a HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function |c Sheetal Kaw, Swetha Ananth, Nikolaos Tsopoulidis, Katharina Morath, Bahar M Coban, Ralph Hohenberger, Olcay C Bulut, Florian Klein, Bettina Stolp & Oliver T Fackler |
| 264 | 1 | |c 4 November 2020 | |
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.12.2023 | ||
| 520 | |a Failures to produce neutralizing antibodies upon HIV‐1 infection result in part from B‐cell dysfunction due to unspecific B‐cell activation. How HIV‐1 affects antigen‐specific B‐cell functions remains elusive. Using an adoptive transfer mouse model and ex vivo HIV infection of human tonsil tissue, we found that expression of the HIV‐1 pathogenesis factor NEF in CD4 T cells undermines their helper function and impairs cognate B‐cell functions including mounting of efficient specific IgG responses. NEF interfered with T cell help via a specific protein interaction motif that prevents polarized cytokine secretion at the T‐cell-B‐cell immune synapse. This interference reduced B‐cell activation and proliferation and thus disrupted germinal center formation and affinity maturation. These results identify NEF as a key component for HIV‐mediated dysfunction of antigen‐specific B cells. Therapeutic targeting of the identified molecular surface in NEF will facilitate host control of HIV infection. | ||
| 650 | 4 | |a B‐cell dysfunction | |
| 650 | 4 | |a HIV‐1 infection | |
| 650 | 4 | |a immunological synapse | |
| 650 | 4 | |a intravital imaging | |
| 650 | 4 | |a NEF | |
| 700 | 1 | |a Ananth, Swetha |d 1993- |e VerfasserIn |0 (DE-588)1200056019 |0 (DE-627)168225092X |4 aut | |
| 700 | 1 | |a Tsopoulidis, Nikolaos |e VerfasserIn |0 (DE-588)1122119240 |0 (DE-627)875170927 |0 (DE-576)48113896X |4 aut | |
| 700 | 1 | |a Morath, Katharina |e VerfasserIn |0 (DE-588)1246985810 |0 (DE-627)1780397941 |4 aut | |
| 700 | 1 | |a Coban, Bahar M |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hohenberger, Ralph |d 1990- |e VerfasserIn |0 (DE-588)1137859903 |0 (DE-627)895138069 |0 (DE-576)491772025 |4 aut | |
| 700 | 1 | |a Bulut, Cem |d 1983- |e VerfasserIn |0 (DE-588)137442718 |0 (DE-627)592634116 |0 (DE-576)303564741 |4 aut | |
| 700 | 1 | |a Klein, Florian |d 1991- |e VerfasserIn |0 (DE-588)1198968052 |0 (DE-627)1681188961 |4 aut | |
| 700 | 1 | |a Stolp-Rastätter, Bettina |e VerfasserIn |0 (DE-588)143053744 |0 (DE-627)641866151 |0 (DE-576)334805457 |4 aut | |
| 700 | 1 | |a Fackler, Oliver Till |e VerfasserIn |0 (DE-588)1026682444 |0 (DE-627)727057391 |0 (DE-576)178094501 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t The EMBO journal |d [London] : Nature Publishing Group UK, 1982 |g 39(2020), 24, Artikel-ID e105594, Seite 1-18 |h Online-Ressource |w (DE-627)266022529 |w (DE-600)1467419-1 |w (DE-576)075961377 |x 1460-2075 |7 nnas |
| 773 | 1 | 8 | |g volume:39 |g year:2020 |g number:24 |g elocationid:e105594 |g pages:1-18 |g extent:18 |a HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function |
| 856 | 4 | 0 | |u https://doi.org/10.15252/embj.2020105594 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.embopress.org/doi/full/10.15252/embj.2020105594 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231218 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1026682444 |a Fackler, Oliver Till |m 1026682444:Fackler, Oliver Till |d 910000 |d 911700 |e 910000PF1026682444 |e 911700PF1026682444 |k 0/910000/ |k 1/910000/911700/ |p 10 |y j | ||
| 998 | |g 143053744 |a Stolp-Rastätter, Bettina |m 143053744:Stolp-Rastätter, Bettina |d 910000 |d 911700 |e 910000PS143053744 |e 911700PS143053744 |k 0/910000/ |k 1/910000/911700/ |p 9 | ||
| 998 | |g 1198968052 |a Klein, Florian |m 1198968052:Klein, Florian |d 20000 |d 21000 |e 20000PK1198968052 |e 21000PK1198968052 |k 0/20000/ |k 1/20000/21000/ |p 8 | ||
| 998 | |g 137442718 |a Bulut, Cem |m 137442718:Bulut, Cem |d 50000 |e 50000PB137442718 |k 0/50000/ |p 7 | ||
| 998 | |g 1137859903 |a Hohenberger, Ralph |m 1137859903:Hohenberger, Ralph |d 910000 |d 911000 |e 910000PH1137859903 |e 911000PH1137859903 |k 0/910000/ |k 1/910000/911000/ |p 6 | ||
| 998 | |g 1246985810 |a Morath, Katharina |m 1246985810:Morath, Katharina |d 910000 |d 911700 |e 910000PM1246985810 |e 911700PM1246985810 |k 0/910000/ |k 1/910000/911700/ |p 4 | ||
| 998 | |g 1200056019 |a Ananth, Swetha |m 1200056019:Ananth, Swetha |d 910000 |d 911700 |e 910000PA1200056019 |e 911700PA1200056019 |k 0/910000/ |k 1/910000/911700/ |p 2 | ||
| 999 | |a KXP-PPN1876317736 |e 4440102786 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"4 November 2020"}],"name":{"displayForm":["Sheetal Kaw, Swetha Ananth, Nikolaos Tsopoulidis, Katharina Morath, Bahar M Coban, Ralph Hohenberger, Olcay C Bulut, Florian Klein, Bettina Stolp & Oliver T Fackler"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.15252/embj.2020105594"],"eki":["1876317736"]},"recId":"1876317736","person":[{"given":"Sheetal","role":"aut","family":"Kaw","display":"Kaw, Sheetal"},{"family":"Ananth","role":"aut","display":"Ananth, Swetha","given":"Swetha"},{"display":"Tsopoulidis, Nikolaos","role":"aut","family":"Tsopoulidis","given":"Nikolaos"},{"given":"Katharina","family":"Morath","role":"aut","display":"Morath, Katharina"},{"given":"Bahar M","role":"aut","family":"Coban","display":"Coban, Bahar M"},{"role":"aut","family":"Hohenberger","display":"Hohenberger, Ralph","given":"Ralph"},{"display":"Bulut, Cem","family":"Bulut","role":"aut","given":"Cem"},{"display":"Klein, Florian","family":"Klein","role":"aut","given":"Florian"},{"family":"Stolp-Rastätter","role":"aut","display":"Stolp-Rastätter, Bettina","given":"Bettina"},{"display":"Fackler, Oliver Till","family":"Fackler","role":"aut","given":"Oliver Till"}],"language":["eng"],"note":["Gesehen am 18.12.2023"],"title":[{"title_sort":"HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function","title":"HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function"}],"physDesc":[{"extent":"18 S."}],"relHost":[{"title":[{"title_sort":"EMBO journal","title":"The EMBO journal"}],"disp":"European Molecular Biology OrganizationThe EMBO journal","origin":[{"publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]","dateIssuedKey":"1982","dateIssuedDisp":"1982-","publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publ. Group ; Wiley"}],"corporate":[{"display":"European Molecular Biology Organization","role":"aut"}],"id":{"doi":["10.1002/(ISSN)1460-2075"],"zdb":["1467419-1"],"eki":["266022529"],"issn":["1460-2075"]},"pubHistory":["1.1982 -"],"note":["Gesehen am 18.02.2016","Fortsetzung der Druckausgabe"],"titleAlt":[{"title":"The EMBO journal online"}],"part":{"text":"39(2020), 24, Artikel-ID e105594, Seite 1-18","volume":"39","extent":"18","pages":"1-18","year":"2020","issue":"24"},"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["publ. for the European Molecular Biology Organization"]},"recId":"266022529","type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"]}]} | ||
| SRT | |a KAWSHEETALHIV1INFECT4202 | ||