The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia
Ataxia-telangiectasia (A-T) is a multisystem recessive disease characterized by cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency and increased risk of cancer. The ATM gene, responsible for A-T, was recently cloned at human chromosome band 11q22-23, a region of frequent alterations...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1998
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| In: |
British journal of haematology
Year: 1998, Volume: 103, Issue: 2, Pages: 536-538 |
| ISSN: | 1365-2141 |
| DOI: | 10.1046/j.1365-2141.1998.00993.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2141.1998.00993.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.1998.00993.x 
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| Author Notes: | Seisho Takeuchi, Michiaki Koike, Susan Park, Taku Seriu, Claus R. Bartram, Harry E. Taub, Ian K. Williamson, Jeffrey Grewal, Hirokuni Taguchi, H. Phillip Koeffler |
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| 245 | 1 | 4 | |a The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia |c Seisho Takeuchi, Michiaki Koike, Susan Park, Taku Seriu, Claus R. Bartram, Harry E. Taub, Ian K. Williamson, Jeffrey Grewal, Hirokuni Taguchi, H. Phillip Koeffler |
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| 520 | |a Ataxia-telangiectasia (A-T) is a multisystem recessive disease characterized by cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency and increased risk of cancer. The ATM gene, responsible for A-T, was recently cloned at human chromosome band 11q22-23, a region of frequent alterations in childhood acute lymphoblastic leukaemia (ALL). Children with A-T frequently develop T-ALL. We investigated 18 T-ALL samples for ATM mutations and loss of heterozygosity (LOH) at the ATM locus. No mutations of ATM were found within the coding region in the 18 T-ALL samples, and LOH at the ATM locus was detected in three. The ATM gene appears to be an infrequently altered tumour suppressor gene in childhood T-ALL. | ||
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| 650 | 4 | |a ATM | |
| 650 | 4 | |a LOH | |
| 650 | 4 | |a tumour suppressor gene | |
| 700 | 1 | |a Koike, Michiaki |e VerfasserIn |4 aut | |
| 700 | 1 | |a Park, Susan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seriu, Taku |e VerfasserIn |0 (DE-588)1315045761 |0 (DE-627)1877282812 |4 aut | |
| 700 | 1 | |a Bartram, Claus R. |d 1952- |e VerfasserIn |0 (DE-588)139758518 |0 (DE-627)613089502 |0 (DE-576)312997159 |4 aut | |
| 700 | 1 | |a Taub, Harry E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Williamson, Ian K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grewal, Jeffrey |e VerfasserIn |4 aut | |
| 700 | 1 | |a Taguchi, Hirokuni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koeffler, H. Phillip |e VerfasserIn |4 aut | |
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