Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood

Background - Sensitive techniques for detection of minimal residual disease (MRD) at degrees of one leukaemic cell per 103-106 cells (10−3-10−6) during follow-up of children with acute lymphoblastic leukaemia (ALL) can provide insight into the effectiveness of cytotoxic treatment. However, it is not...

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Main Authors:	Van Dongen, Jacques J. M. (Author) , Seriu, Taku (Author) , Panzer-Grümayer, E Renate (Author) , Biondi, Andrea (Author) , Pongers-Willemse, Marja J (Author) , Corral, Lilly (Author) , Stolz, Frank (Author) , Schrappe, Martin (Author) , Masera, Giuseppe (Author) , Kamps, Willem A (Author) , Gadner, Helmuth (Author) , van Wering, Elisabeth R (Author) , Ludwig, Wolf-Dieter (Author) , Basso, Giuseppe (Author) , de Bruijn, Marianne AC (Author) , Cazzaniga, Giovanni (Author) , Hettinger, Klaudia (Author) , van der Does-van den Berg, Anna (Author) , Hop, Wim CJ (Author) , Riehm, Hansjörg (Author) , Bartram, Claus R. (Author)
Format:	Article (Journal)
Language:	English
Published:	28 November 1998
In:	The lancet Year: 1998, Volume: 352, Issue: 9142, Pages: 1731-1738
ISSN:	1474-547X
DOI:	10.1016/S0140-6736(98)04058-6
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0140-6736(98)04058-6 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0140673698040586
Author Notes:	Jacques JM van Dongen, Taku Seriu, E Renate Panzer-Grümayer, Andrea Biondi, Marja J Pongers-Willemse, Lilly Corral, Frank Stolz, Martin Schrappe, Giuseppe Masera, Willem A Kamps, Helmuth Gadner, Elisabeth R van Wering, Wolf-Dieter Ludwig, Giuseppe Basso, Marianne AC de Bruijn, Giovanni Cazzaniga, Klaudia Hettinger, Anna van der Does-van den Berg, Wim CJ Hop, Hansjörg Riehm, Claus R Bartram