Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model

Plexiform neurofibromas (PNF), one of the major features of neurofibromatosis type 1 (NF1), are characterized by complex cellular composition and mostly slow but variable growth patterns. In this study, we examined the effect of imatinib mesylate, a receptor tyrosine kinase inhibitor, on PNF-derived...

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Bibliographic Details

Main Authors:	Demestre, Maria (Author) , Herzberg, Jan (Author) , Holtkamp, Nikola (Author) , Hagel, Christian (Author) , Reuss, David (Author) , Friedrich, Reinhard E. (Author) , Kluwe, Lan (Author) , Deimling, Andreas von (Author) , Mautner, Victor Felix (Author) , Kurtz, Andreas (Author)
Format:	Article (Journal)
Language:	English
Published:	2010
In:	Journal of neuro-oncology Year: 2010, Volume: 98, Issue: 1, Pages: 11-19
ISSN:	1573-7373
DOI:	10.1007/s11060-009-0049-4
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11060-009-0049-4
Author Notes:	Maria Demestre, Jan Herzberg, Nikola Holtkamp, Christian Hagel, David Reuss, Reinhard E. Friedrich, Lan Kluwe, Andreas von Deimling, Victor-F. Mautner, Andreas Kurtz