Cardiovascular outcomes in de novo Kidney transplant recipients receiving everolimus and reduced calcineurin inhibitor or standard triple therapy: 24-month post hoc analysis from TRANSFORM study
Background. - The comparative impact of everolimus (EVR)-based regimens versus standard of care (mycophenolic acid+standard calcineurin inhibitor [MPA+sCNI]) on cardiovascular outcomes in de novo kidney transplant recipients (KTRs) is poorly understood. The incidence of major adverse card...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2023
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| In: |
Transplantation
Year: 2023, Jahrgang: 107, Heft: 7, Pages: 1593-1604 |
| ISSN: | 1534-6080 |
| DOI: | 10.1097/TP.0000000000004555 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/TP.0000000000004555 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/transplantjournal/fulltext/2023/07000/cardiovascular_outcomes_in_de_novo_kidney.25.aspx 
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| Verfasserangaben: | Claudia Sommerer, Christophe Legendre, Franco Citterio, Yoshihiko Watarai, Rainer Oberbauer, Nikolina Basic-Jukic, Jackie Han, Apurva Gawai, Peter Bernhardt, and Steve Chadban |
MARC
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| 245 | 1 | 0 | |a Cardiovascular outcomes in de novo Kidney transplant recipients receiving everolimus and reduced calcineurin inhibitor or standard triple therapy |b 24-month post hoc analysis from TRANSFORM study |c Claudia Sommerer, Christophe Legendre, Franco Citterio, Yoshihiko Watarai, Rainer Oberbauer, Nikolina Basic-Jukic, Jackie Han, Apurva Gawai, Peter Bernhardt, and Steve Chadban |
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| 520 | |a Background. - The comparative impact of everolimus (EVR)-based regimens versus standard of care (mycophenolic acid+standard calcineurin inhibitor [MPA+sCNI]) on cardiovascular outcomes in de novo kidney transplant recipients (KTRs) is poorly understood. The incidence of major adverse cardiac events (MACEs) in KTRs receiving EVR+reduced CNI (rCNI) or MPA+sCNI from the TRANSplant eFficacy and safety Outcomes with an eveRolimus-based regiMen study was evaluated. - Methods. - The incidence of MACE was determined for all randomized patients receiving at least 1 dose of the study drug. Factors associated with MACEs were determined by logistic regression. Risk of MACE out to 3 y post-study was calculated using the Patient Outcome in Renal Transplantation equation. - Results. - MACE occurred in 81 of 1014 (8.0%; EVR+rCNI) versus 89 of 1012 (8.8%; MPA+sCNI) KTRs (risk ratio, 0.91 [95% confidence interval [CI], 0.68-1.21]). The incidence of circulatory death, myocardial infarction, revascularization, or angina was similar between the arms. Incidence of MACE was similar between EVR+rCNI and MPA+sCNI arms with a higher incidence in prespecified risk groups: older age, pretransplant diabetes (15.1% versus 15.9%), statin use (8.5% versus 10.8%), and low estimated glomerular filtration rate (Month 2 estimated glomerular filtration rate <30 versus >60 mL/min/1.73 m2; odds ratio, 2.23 [95% CI, 1.02-4.86]; P = 0.044), respectively. Predicted risk of MACE within 3 y of follow-up did not differ between the treatment arms. - Conclusions. - Cardiovascular morbidity and mortality were similar between de novo KTRs receiving EVR+rCNI and MPA+sCNI. EVR+rCNI is a viable alternative to the current standard of care in KTRs. - - - - - Export | ||
| 700 | 1 | |a Legendre, Christophe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Citterio, Franco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Watarai, Yoshihiko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oberbauer, Rainer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Basic-Jukic, Nikolina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Han, Jackie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gawai, Apurva |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bernhardt, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chadban, Steve |e VerfasserIn |4 aut | |
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