Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis
In Rheumatoid Arthritis (RA), regulatory T cells (Tregs) have been found to be enriched in the synovial fluid. Despite their accumulation, they are unable to suppress synovial inflammation. Recently, we showed the synovial enrichment of interleukin-9 (IL-9) producing helper T cells and its positive...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2023
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| In: |
Clinical immunology
Year: 2023, Jahrgang: 257, Pages: 1-13 |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2023.109814 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clim.2023.109814 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1521661623005776 
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| Verfasserangaben: | Sushmita Chakraborty, Ranjan Gupta, Katharina F. Kubatzky, Santanu Kar, Franziska V. Kraus, M. Margarida Souto-Carneiro, Hanns-Martin Lorenz, Pankaj Kumar, Vijay Kumar, Dipendra Kumar Mitra |
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| 245 | 1 | 0 | |a Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis |c Sushmita Chakraborty, Ranjan Gupta, Katharina F. Kubatzky, Santanu Kar, Franziska V. Kraus, M. Margarida Souto-Carneiro, Hanns-Martin Lorenz, Pankaj Kumar, Vijay Kumar, Dipendra Kumar Mitra |
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| 520 | |a In Rheumatoid Arthritis (RA), regulatory T cells (Tregs) have been found to be enriched in the synovial fluid. Despite their accumulation, they are unable to suppress synovial inflammation. Recently, we showed the synovial enrichment of interleukin-9 (IL-9) producing helper T cells and its positive correlation with disease activity. Therefore, we investigated the impact of IL-9 on synovial Tregs in RA. Here, we confirmed high synovial Tregs in RA patients, however these cells were functionally impaired in terms of suppressive cytokine production (IL-10 and TGF-β). Abrogating IL-9/ IL-9 receptor interaction could restore the suppressive cytokine production of synovial Tregs and reduce the synovial inflammatory T cells producing IFN-γ, TNF-α, IL-17. However, blocking these inflammatory cytokines failed to show any effect on IL-9 producing T cells, highlighting IL-9's hierarchy in the inflammatory network. Thus, we propose that blocking IL-9 might dampen synovial inflammation by restoring Tregs function and inhibiting inflammatory T cells. | ||
| 650 | 4 | |a Inflammatory cytokines | |
| 650 | 4 | |a Interleukin −9 | |
| 650 | 4 | |a Regulatory T cells | |
| 650 | 4 | |a Rheumatoid arthritis | |
| 650 | 4 | |a Synovial fluid | |
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