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Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression

Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differenc...

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Main Authors: Argyelan, Miklos (Author) , Deng, Zhi-De (Author) , Ousdal, Olga Therese (Author) , Oltedal, Leif (Author) , Angulo, Brian (Author) , Baradits, Mate (Author) , Spitzberg, Andrew J. (Author) , Kessler, Ute (Author) , Sartorius, Alexander (Author) , Dols, Annemiek (Author) , Narr, Katherine L. (Author) , Espinoza, Randall (Author) , van Waarde, Jeroen A. (Author) , Tendolkar, Indira (Author) , van Eijndhoven, Philip (Author) , Wingen, Guido Alexander van (Author) , Takamiya, Akihiro (Author) , Kishimoto, Taishiro (Author) , Jorgensen, Martin B. (Author) , Jorgensen, Anders (Author) , Paulson, Olaf B. (Author) , Yrondi, Antoine (Author) , Péran, Patrice (Author) , Soriano-Mas, Carles (Author) , Cardoner, Narcis (Author) , Cano, Marta (Author) , van Diermen, Linda (Author) , Schrijvers, Didier (Author) , Belge, Jean-Baptiste (Author) , Emsell, Louise (Author) , Bouckaert, Filip (Author) , Vandenbulcke, Mathieu (Author) , Kiebs, Maximilian (Author) , Hurlemann, René (Author) , Mulders, Peter C. R. (Author) , Redlich, Ronny (Author) , Dannlowski, Udo (Author) , Kavakbasi, Erhan (Author) , Kritzer, Michael D. (Author) , Ellard, Kristen K. (Author) , Camprodon, Joan A. (Author) , Petrides, Georgios (Author) , Malhotra, Anil K. (Author) , Abbott, Christopher C. (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: Molecular psychiatry
Year: 2024, Volume: 29, Issue: 2, Pages: 229-237
ISSN:1476-5578
DOI:10.1038/s41380-023-02318-2
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41380-023-02318-2
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41380-023-02318-2
Resolving-System, kostenfrei: https://doi.org/10.25673/116782
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Author Notes:Miklos Argyelan, Zhi-De Deng, Olga Therese Ousdal, Leif Oltedal, Brian Angulo, Mate Baradits, Andrew J. Spitzberg, Ute Kessler, Alexander Sartorius, Annemiek Dols, Katherine L. Narr, Randall Espinoza, Jeroen A. van Waarde, Indira Tendolkar, Philip van Eijndhoven, Guido A. van Wingen, Akihiro Takamiya, Taishiro Kishimoto, Martin B. Jorgensen, Anders Jorgensen, Olaf B. Paulson, Antoine Yrondi, Patrice Péran, Carles Soriano-Mas, Narcis Cardoner, Marta Cano, Linda van Diermen, Didier Schrijvers, Jean-Baptiste Belge, Louise Emsell, Filip Bouckaert, Mathieu Vandenbulcke, Maximilian Kiebs, René Hurlemann, Peter CR. Mulders, Ronny Redlich, Udo Dannlowski, Erhan Kavakbasi, Michael D. Kritzer, Kristen K. Ellard, Joan A. Camprodon, Georgios Petrides, Anil K. Malhotra and Christopher C. Abbott
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Summary:Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = −2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.
Item Description:Gesehen am 06.03.2024
Physical Description:Online Resource
ISSN:1476-5578
DOI:10.1038/s41380-023-02318-2

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