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Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells

HIV-infected individuals and SIV-infected rhesus macaques have, on the average, decreased plasma cysteine and cystine concentrations and decreased intracellular glutathione levels. We show that the cysteine supply and the intracellular glutathione levels have a strong influence on the T cell system,...

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Hauptverfasser: Kinscherf, Ralf (VerfasserIn) , Fischbach, Thomas (VerfasserIn) , Mihm, Sabine (VerfasserIn) , Roth, Steffen (VerfasserIn) , Hohenhaus-Sievert, Elke (VerfasserIn) , Weiss, Claus (VerfasserIn) , Edler, Lutz (VerfasserIn) , Bärtsch, Peter (VerfasserIn) , Dröge, Wulf (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1994
In: The FASEB journal
Year: 1994, Jahrgang: 8, Heft: 6, Pages: 448-451
ISSN:1530-6860
DOI:10.1096/fasebj.8.6.7909525
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1096/fasebj.8.6.7909525
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.8.6.7909525
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Verfasserangaben:Ralf Kinscherf, Thomas Fischbach, Sabine Mihm, Steffen Roth, Elke Hohenhaus-Sievert, Claus Weiss, Lutz Edler, Peter Bärtsch, Wulf Dröge
Beschreibung
Zusammenfassung:HIV-infected individuals and SIV-infected rhesus macaques have, on the average, decreased plasma cysteine and cystine concentrations and decreased intracellular glutathione levels. We show that the cysteine supply and the intracellular glutathione levels have a strong influence on the T cell system, A study of healthy human subjects revealed that persons with intracellular glutathione levels of 20-30 nmol/mg protein had significantly higher numbers of CD4+ T cells than persons with either lower or higher glutathione levels. Persons who moved during a 4-weck observation period from the optimal to the suboptimal range (10-20 nmol/mg) experienced, on the average, a 30% decrease in CD4+ T cell numbers. This decrease was prevented by treatment with N-acetyl-cysteine (NAC). NAC caused this relative increase of CD4+ T cell numbers in spite of decreasing glutathione levels and not by increasing the glutathione level. Our studies suggest that the immune system may be exquisitely sensitive not only against a cysteine and glutathione deficiency but also against an excess of cysteine.—Kinscherf, R., Fischbach, T., Mihm, S., Roth, S., Hohenhaus-Sievert, E., Weiss, C., Edler, L., Bärtsch, P., Dröge, W. Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells. FASEB J. 8: 448-451; 1994.
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Beschreibung:Online Resource
ISSN:1530-6860
DOI:10.1096/fasebj.8.6.7909525

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