Changes of the salivary and serum proteome in canine hypothyroidism
In this study, changes in salivary and serum proteome of dogs with hypothyroidism were studied using tandem mass tags (TMT) labelling and liquid chromatography-mass spectrometry (LC-MS/MS). Saliva and serum proteome from 10 dogs with hypothyroidism were compared with 10 healthy dogs. In saliva, a to...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Weitere Verfasser: | |
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2024
|
| In: |
Domestic animal endocrinology
Year: 2024, Jahrgang: 86, Pages: 1-9 |
| ISSN: | 1879-0054 |
| DOI: | 10.1016/j.domaniend.2023.106825 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.domaniend.2023.106825 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0739724023000413 
|
| Verfasserangaben: | L.G. González-Arostegui, A. Muñoz-Prieto, C.P. Rubio, J.J. Cerón, L. Bernal, I. Rubić, V. Mrljak, J.C. González-Sánchez, A. Tvarijonaviciute |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 187871256X | ||
| 003 | DE-627 | ||
| 005 | 20240307020940.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240123s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.domaniend.2023.106825 |2 doi | |
| 035 | |a (DE-627)187871256X | ||
| 035 | |a (DE-599)KXP187871256X | ||
| 035 | |a (OCoLC)1425200312 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a González-Aróstegui, Luis G. |d 1993- |e VerfasserIn |0 (DE-588)1316966798 |0 (DE-627)1878718185 |4 aut | |
| 245 | 1 | 0 | |a Changes of the salivary and serum proteome in canine hypothyroidism |c L.G. González-Arostegui, A. Muñoz-Prieto, C.P. Rubio, J.J. Cerón, L. Bernal, I. Rubić, V. Mrljak, J.C. González-Sánchez, A. Tvarijonaviciute |
| 264 | 1 | |c January 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 2. November 2023, Artikelversion: 17. November 2023 | ||
| 500 | |a Gesehen am 23.01.2024 | ||
| 520 | |a In this study, changes in salivary and serum proteome of dogs with hypothyroidism were studied using tandem mass tags (TMT) labelling and liquid chromatography-mass spectrometry (LC-MS/MS). Saliva and serum proteome from 10 dogs with hypothyroidism were compared with 10 healthy dogs. In saliva, a total of seven proteins showed significant changes between the two groups, being six downregulated and one upregulated, meanwhile, in serum, a total of six proteins showed significant changes, being five downregulated and one upregulated. The altered proteins reflected metabolic and immunologic changes, as well as, skin and coagulation alterations, and these proteins were not affected by gender. One of the proteins that were downregulated in saliva, lactate dehydrognease (LDH), was measured by a spectrophotometric assay in saliva samples from 42 dogs with hypothyroidism, 42 dogs with non-thyroid diseases and 46 healthy dogs. The activity of LDH was lower in the saliva of hypothyroid dogs when compared to non-thyroid diseased dogs and healthy controls. This study indicates that canine hypothyroidism can produce changes in the proteome of saliva and serum. These two sample types showed different variations in their proteins reflecting physiopathological changes that occur in this disease, mainly related to the immune system, metabolism, skin and coagulation. In addition, some of the proteins identified in this study, specially LDH in saliva, should be further explored as potential biomarkers of canine hypothyroidism. | ||
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Dogs | |
| 650 | 4 | |a Hypothyroidism | |
| 650 | 4 | |a Proteins | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a Saliva | |
| 700 | 1 | |a Muñoz Prieto, Alberto |e VerfasserIn |0 (DE-588)1260684369 |0 (DE-627)1807551830 |4 aut | |
| 700 | 1 | |a Rubio, C. P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cerón, J. J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bernal, L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rubić, I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mrljak, V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a González Sánchez, Juan Carlos |d 1987- |0 (DE-588)118600150X |0 (DE-627)1665286881 |4 oth | |
| 700 | 1 | |a Tvarijonaviciute, A. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Domestic animal endocrinology |d Amsterdam [u.a.] : Elsevier Science, 1984 |g 86(2024) vom: Jan., Artikel-ID 106825, Seite 1-9 |h Online-Ressource |w (DE-627)306580659 |w (DE-600)1497551-8 |w (DE-576)263808181 |x 1879-0054 |7 nnas |a Changes of the salivary and serum proteome in canine hypothyroidism |
| 773 | 1 | 8 | |g volume:86 |g year:2024 |g month:01 |g elocationid:106825 |g pages:1-9 |g extent:9 |a Changes of the salivary and serum proteome in canine hypothyroidism |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.domaniend.2023.106825 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0739724023000413 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240123 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 118600150X |a González Sánchez, Juan Carlos |m 118600150X:González Sánchez, Juan Carlos |d 700000 |d 716000 |e 700000PG118600150X |e 716000PG118600150X |k 0/700000/ |k 1/700000/716000/ |p 8 | ||
| 999 | |a KXP-PPN187871256X |e 4466429197 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Online verfügbar: 2. November 2023, Artikelversion: 17. November 2023","Gesehen am 23.01.2024"],"physDesc":[{"extent":"9 S.","noteIll":"Illustrationen"}],"person":[{"display":"González-Aróstegui, Luis G.","role":"aut","roleDisplay":"VerfasserIn","family":"González-Aróstegui","given":"Luis G."},{"given":"Alberto","family":"Muñoz Prieto","display":"Muñoz Prieto, Alberto","role":"aut","roleDisplay":"VerfasserIn"},{"given":"C. P.","family":"Rubio","roleDisplay":"VerfasserIn","role":"aut","display":"Rubio, C. P."},{"role":"aut","display":"Cerón, J. J.","roleDisplay":"VerfasserIn","given":"J. J.","family":"Cerón"},{"family":"Bernal","given":"L.","display":"Bernal, L.","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Rubić, I.","role":"aut","family":"Rubić","given":"I."},{"given":"V.","family":"Mrljak","roleDisplay":"VerfasserIn","display":"Mrljak, V.","role":"aut"},{"given":"Juan Carlos","family":"González Sánchez","role":"oth","display":"González Sánchez, Juan Carlos"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Tvarijonaviciute, A.","family":"Tvarijonaviciute","given":"A."}],"name":{"displayForm":["L.G. González-Arostegui, A. Muñoz-Prieto, C.P. Rubio, J.J. Cerón, L. Bernal, I. Rubić, V. Mrljak, J.C. González-Sánchez, A. Tvarijonaviciute"]},"recId":"187871256X","id":{"doi":["10.1016/j.domaniend.2023.106825"],"eki":["187871256X"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"id":{"zdb":["1497551-8"],"issn":["1879-0054"],"eki":["306580659"]},"recId":"306580659","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 08.02.2021"],"pubHistory":["1.1984 -"],"part":{"year":"2024","extent":"9","pages":"1-9","volume":"86","text":"86(2024) vom: Jan., Artikel-ID 106825, Seite 1-9"},"disp":"Changes of the salivary and serum proteome in canine hypothyroidismDomestic animal endocrinology","language":["eng"],"title":[{"title":"Domestic animal endocrinology","title_sort":"Domestic animal endocrinology","subtitle":"a scientific journal devoted to the endocrinology of domestic animal species"}],"origin":[{"dateIssuedKey":"1984","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1984-","publisher":"Elsevier Science"}],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"January 2024"}],"title":[{"title":"Changes of the salivary and serum proteome in canine hypothyroidism","title_sort":"Changes of the salivary and serum proteome in canine hypothyroidism"}],"language":["eng"]} | ||
| SRT | |a GONZALEZARCHANGESOFT2024 | ||