HLA-E and its soluble form as indicators of a sex-specific immune response in patients with rral squamous cell carcinoma
The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carc...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 November 2023
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| In: |
International journal of molecular sciences
Year: 2023, Jahrgang: 24, Heft: 23, Pages: 1-13 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms242316699 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms242316699 Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/24/23/16699 
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| Verfasserangaben: | Anne Radermacher, Michael Fehrenz, Tamara Bellin, Carolina Claßen, Laura Möller, Ann-Kristin Struckmeier, Mathias Wagner, Philipp Wartenberg, Julius Moratin, Christian Freudlsperger, Kolja Freier and Dominik Horn |
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| 245 | 1 | 0 | |a HLA-E and its soluble form as indicators of a sex-specific immune response in patients with rral squamous cell carcinoma |c Anne Radermacher, Michael Fehrenz, Tamara Bellin, Carolina Claßen, Laura Möller, Ann-Kristin Struckmeier, Mathias Wagner, Philipp Wartenberg, Julius Moratin, Christian Freudlsperger, Kolja Freier and Dominik Horn |
| 246 | 1 | |i Titel des special issue |a Oral Squamous Cell Carcinoma—Pathogenetic, Diagnostic and Therapeutic Perspectives | |
| 264 | 1 | |c 24 November 2023 | |
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| 500 | |a Gesehen am 24.01.2024 | ||
| 520 | |a The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carcinomas (OSCC) after surgical therapy. Then, serum concentration of HLA-E (sHLA-E) was quantified in a prospective cohort by enzyme-linked immunosorbent assay. High HLA-E expression was associated with advanced UICC stage (Spearman’s correlation: p = 0.002) and worse survival (Cox-regression: progression-free survival: hazard ratio (HR) 3.129, confidence range (CI) 1.443-6.787, p = 0.004; overall survival: HR 2.328, CI 1.071-5.060, p = 0.033). The sHLA-E concentration was significantly higher in the control group than in tumor group (Mann-Whitney U-test (MW-U): p = 0.021). Within the tumor group, women showed significantly higher sHLA-E levels than men (MW-U: p = 0.049). A closer look at the tumor group and the control group showed that gender-specific differences exist: while no differences in sHLA-E concentration were detectable between female subjects of tumor group and control group (MW-U: p = 0.916), male subjects of tumor group had a significantly lower sHLA-E concentration compared to those of control group (MW-U: p = 0.001). In summary, our results provide evidence for sex-specific differences in immune responses in OSCC. This fact should be considered regarding future immunotherapy regimens. | ||
| 650 | 4 | |a HLA-E | |
| 650 | 4 | |a immunotherapy | |
| 650 | 4 | |a oral squamous cell carcinoma (OSCC) | |
| 650 | 4 | |a sex-related differences in immune response | |
| 650 | 4 | |a soluble HLA-E | |
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