Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase
Most organisms synthesise the B(6) vitamer pyridoxal 5-phosphate (PLP) via the glutamine amidotransferase PLP synthase, a large enzyme complex of 12 Pdx1 synthase subunits with up to 12 Pdx2 glutaminase subunits attached. Deletion analysis revealed that the C-terminus has four distinct functionaliti...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 September 2010
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| In: |
FEBS letters
Year: 2010, Jahrgang: 584, Heft: 19, Pages: 4169-4174 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2010.09.013 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.febslet.2010.09.013
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| Verfasserangaben: | Bianca Derrer, Volker Windeisen, Gabriela Guédez Rodríguez, Joerg Seidler, Martin Gengenbacher, Wolf D. Lehmann, Karsten Rippe, Irmgard Sinning, Ivo Tews, Barbara Kappes |
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| 245 | 1 | 0 | |a Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase |c Bianca Derrer, Volker Windeisen, Gabriela Guédez Rodríguez, Joerg Seidler, Martin Gengenbacher, Wolf D. Lehmann, Karsten Rippe, Irmgard Sinning, Ivo Tews, Barbara Kappes |
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| 520 | |a Most organisms synthesise the B(6) vitamer pyridoxal 5-phosphate (PLP) via the glutamine amidotransferase PLP synthase, a large enzyme complex of 12 Pdx1 synthase subunits with up to 12 Pdx2 glutaminase subunits attached. Deletion analysis revealed that the C-terminus has four distinct functionalities: assembly of the Pdx1 monomers, binding of the pentose substrate (ribose 5-phosphate), formation of the reaction intermediate I(320), and finally PLP synthesis. Deletions of distinct C-terminal regions distinguish between these individual functions. PLP formation is the only function that is conferred to the enzyme by the C-terminus acting in trans, explaining the cooperative nature of the complex. | ||
| 650 | 4 | |a Amino Acid Sequence | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Base Sequence | |
| 650 | 4 | |a DNA, Protozoan | |
| 650 | 4 | |a Glutaminase | |
| 650 | 4 | |a Kinetics | |
| 650 | 4 | |a Models, Molecular | |
| 650 | 4 | |a Molecular Sequence Data | |
| 650 | 4 | |a Multiprotein Complexes | |
| 650 | 4 | |a Plasmodium falciparum | |
| 650 | 4 | |a Protein Subunits | |
| 650 | 4 | |a Protozoan Proteins | |
| 650 | 4 | |a Pyridoxal Phosphate | |
| 650 | 4 | |a Recombinant Proteins | |
| 650 | 4 | |a Ribosemonophosphates | |
| 650 | 4 | |a Sequence Deletion | |
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