Buchumschlag

Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

Tumor-derived extracellular vesicles (EVs) have been associated with immune evasion and tumor progression. We show that the RNA-sensing receptor RIG-I within tumor cells governs biogenesis and immunomodulatory function of EVs. Cancer-intrinsic RIG-I activation releases EVs, which mediate dendritic c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Heidegger, Simon (VerfasserIn) , Stritzke, Florian (VerfasserIn) , Dahl, Sarah (VerfasserIn) , Daßler-Plenker, Juliane (VerfasserIn) , Joachim, Laura (VerfasserIn) , Buschmann, Dominik (VerfasserIn) , Fan, Kaiji (VerfasserIn) , Sauer, Carolin M. (VerfasserIn) , Ludwig, Nils (VerfasserIn) , Winter, Christof (VerfasserIn) , Enssle, Stefan (VerfasserIn) , Li, Suqi (VerfasserIn) , Perl, Markus (VerfasserIn) , Görgens, André (VerfasserIn) , Haas, Tobias (VerfasserIn) , Orberg, Erik Thiele (VerfasserIn) , Göttert, Sascha (VerfasserIn) , Wölfel, Catherine (VerfasserIn) , Engleitner, Thomas (VerfasserIn) , Cortés-Ciriano, Isidro (VerfasserIn) , Rad, Roland (VerfasserIn) , Herr, Wolfgang (VerfasserIn) , Giebel, Bernd (VerfasserIn) , Ruland, Jürgen (VerfasserIn) , Bassermann, Florian (VerfasserIn) , Coch, Christoph (VerfasserIn) , Hartmann, Gunther (VerfasserIn) , Poeck, Hendrik (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 19 September 2023
In: Cell reports. Medicine
Year: 2023, Jahrgang: 4, Heft: 9, Pages: 1-25
ISSN:2666-3791
DOI:10.1016/j.xcrm.2023.101171
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.xcrm.2023.101171
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2666379123003245
Volltext
Verfasserangaben:Simon Heidegger, Florian Stritzke, Sarah Dahl, Juliane Daßler-Plenker, Laura Joachim, Dominik Buschmann, Kaiji Fan, Carolin M. Sauer, Nils Ludwig, Christof Winter, Stefan Enssle, Suqi Li, Markus Perl, André Görgens, Tobias Haas, Erik Thiele Orberg, Sascha Göttert, Catherine Wölfel, Thomas Engleitner, Isidro Cortés-Ciriano, Roland Rad, Wolfgang Herr, Bernd Giebel, Jürgen Ruland, Florian Bassermann, Christoph Coch, Gunther Hartmann, and Hendrik Poeck

MARC

LEADER 00000caa a2200000 c 4500
001 1879092662
003 DE-627
005 20240325174201.0
007 cr uuu---uuuuu
008 240126s2023 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.xcrm.2023.101171  |2 doi 
035 |a (DE-627)1879092662 
035 |a (DE-599)KXP1879092662 
035 |a (OCoLC)1425207634 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Heidegger, Simon  |d 1983-  |e VerfasserIn  |0 (DE-588)1012936740  |0 (DE-627)662776070  |0 (DE-576)346196396  |4 aut 
245 1 0 |a Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy  |c Simon Heidegger, Florian Stritzke, Sarah Dahl, Juliane Daßler-Plenker, Laura Joachim, Dominik Buschmann, Kaiji Fan, Carolin M. Sauer, Nils Ludwig, Christof Winter, Stefan Enssle, Suqi Li, Markus Perl, André Görgens, Tobias Haas, Erik Thiele Orberg, Sascha Göttert, Catherine Wölfel, Thomas Engleitner, Isidro Cortés-Ciriano, Roland Rad, Wolfgang Herr, Bernd Giebel, Jürgen Ruland, Florian Bassermann, Christoph Coch, Gunther Hartmann, and Hendrik Poeck 
264 1 |c 19 September 2023 
300 |a 25 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online verfügbar: 31. August 2023, Artikelversion: 19. September 2023 
500 |a Gesehen am 26.01.2024 
520 |a Tumor-derived extracellular vesicles (EVs) have been associated with immune evasion and tumor progression. We show that the RNA-sensing receptor RIG-I within tumor cells governs biogenesis and immunomodulatory function of EVs. Cancer-intrinsic RIG-I activation releases EVs, which mediate dendritic cell maturation and T cell antitumor immunity, synergizing with immune checkpoint blockade. Intact RIG-I, autocrine interferon signaling, and the GTPase Rab27a in tumor cells are required for biogenesis of immunostimulatory EVs. Active intrinsic RIG-I signaling governs composition of the tumor EV RNA cargo including small non-coding stimulatory RNAs. High transcriptional activity of EV pathway genes and RIG-I in melanoma samples associate with prolonged patient survival and beneficial response to immunotherapy. EVs generated from human melanoma after RIG-I stimulation induce potent antigen-specific T cell responses. We thus define a molecular pathway that can be targeted in tumors to favorably alter EV immunomodulatory function. We propose “reprogramming” of tumor EVs as a personalized strategy for T cell-mediated cancer immunotherapy. 
650 4 |a cancer immunotherapy 
650 4 |a cancer resistance 
650 4 |a extracellular vesicles 
650 4 |a innate immunity 
650 4 |a nucleic acid receptors 
650 4 |a personalized therapy 
650 4 |a RIG-I 
650 4 |a RNA 
650 4 |a STING 
700 1 |a Stritzke, Florian  |e VerfasserIn  |0 (DE-588)1317334337  |0 (DE-627)1879093049  |4 aut 
700 1 |a Dahl, Sarah  |e VerfasserIn  |4 aut 
700 1 |a Daßler-Plenker, Juliane  |e VerfasserIn  |4 aut 
700 1 |a Joachim, Laura  |e VerfasserIn  |4 aut 
700 1 |a Buschmann, Dominik  |e VerfasserIn  |4 aut 
700 1 |a Fan, Kaiji  |e VerfasserIn  |4 aut 
700 1 |a Sauer, Carolin M.  |e VerfasserIn  |4 aut 
700 1 |a Ludwig, Nils  |e VerfasserIn  |4 aut 
700 1 |a Winter, Christof  |e VerfasserIn  |4 aut 
700 1 |a Enssle, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Li, Suqi  |e VerfasserIn  |4 aut 
700 1 |a Perl, Markus  |e VerfasserIn  |4 aut 
700 1 |a Görgens, André  |e VerfasserIn  |4 aut 
700 1 |a Haas, Tobias  |e VerfasserIn  |4 aut 
700 1 |a Orberg, Erik Thiele  |e VerfasserIn  |4 aut 
700 1 |a Göttert, Sascha  |e VerfasserIn  |4 aut 
700 1 |a Wölfel, Catherine  |e VerfasserIn  |4 aut 
700 1 |a Engleitner, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Cortés-Ciriano, Isidro  |e VerfasserIn  |4 aut 
700 1 |a Rad, Roland  |e VerfasserIn  |4 aut 
700 1 |a Herr, Wolfgang  |e VerfasserIn  |4 aut 
700 1 |a Giebel, Bernd  |e VerfasserIn  |4 aut 
700 1 |a Ruland, Jürgen  |e VerfasserIn  |4 aut 
700 1 |a Bassermann, Florian  |e VerfasserIn  |4 aut 
700 1 |a Coch, Christoph  |e VerfasserIn  |4 aut 
700 1 |a Hartmann, Gunther  |e VerfasserIn  |4 aut 
700 1 |a Poeck, Hendrik  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Cell reports. Medicine  |d Cambridge, MA : Cell Press, 2020  |g 4(2023), 9 vom: Sept., Artikel-ID 101171, Seite 1-25  |h Online-Ressource  |w (DE-627)1696877792  |w (DE-600)3019420-9  |x 2666-3791  |7 nnas  |a Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy 
773 1 8 |g volume:4  |g year:2023  |g number:9  |g month:09  |g elocationid:101171  |g pages:1-25  |g extent:25  |a Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy 
856 4 0 |u https://doi.org/10.1016/j.xcrm.2023.101171  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S2666379123003245  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20240126 
993 |a Article 
994 |a 2023 
998 |g 1317334337  |a Stritzke, Florian  |m 1317334337:Stritzke, Florian  |d 910000  |d 911400  |e 910000PS1317334337  |e 911400PS1317334337  |k 0/910000/  |k 1/910000/911400/  |p 2 
999 |a KXP-PPN1879092662  |e 4468219459 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Simon Heidegger, Florian Stritzke, Sarah Dahl, Juliane Daßler-Plenker, Laura Joachim, Dominik Buschmann, Kaiji Fan, Carolin M. Sauer, Nils Ludwig, Christof Winter, Stefan Enssle, Suqi Li, Markus Perl, André Görgens, Tobias Haas, Erik Thiele Orberg, Sascha Göttert, Catherine Wölfel, Thomas Engleitner, Isidro Cortés-Ciriano, Roland Rad, Wolfgang Herr, Bernd Giebel, Jürgen Ruland, Florian Bassermann, Christoph Coch, Gunther Hartmann, and Hendrik Poeck"]},"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Cell reports","partname":"Medicine","title":"Cell reports"}],"part":{"year":"2023","text":"4(2023), 9 vom: Sept., Artikel-ID 101171, Seite 1-25","extent":"25","issue":"9","volume":"4","pages":"1-25"},"note":["Gesehen am 29. April 2020"],"pubHistory":["Volume 1, issue 1 (2020)-"],"disp":"Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapyCell reports. Medicine","recId":"1696877792","origin":[{"publisherPlace":"Cambridge, MA ; Maryland Heights, MO","dateIssuedDisp":"[2020]-","publisher":"Cell Press ; Elsevier"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["3019420-9"],"issn":["2666-3791"],"eki":["1696877792"]},"language":["eng"]}],"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"19 September 2023"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Online verfügbar: 31. August 2023, Artikelversion: 19. September 2023","Gesehen am 26.01.2024"],"title":[{"title_sort":"Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy","title":"Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy"}],"person":[{"role":"aut","given":"Simon","family":"Heidegger","display":"Heidegger, Simon","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Stritzke","display":"Stritzke, Florian","role":"aut","given":"Florian"},{"roleDisplay":"VerfasserIn","display":"Dahl, Sarah","family":"Dahl","role":"aut","given":"Sarah"},{"role":"aut","given":"Juliane","roleDisplay":"VerfasserIn","display":"Daßler-Plenker, Juliane","family":"Daßler-Plenker"},{"roleDisplay":"VerfasserIn","display":"Joachim, Laura","family":"Joachim","given":"Laura","role":"aut"},{"display":"Buschmann, Dominik","family":"Buschmann","roleDisplay":"VerfasserIn","given":"Dominik","role":"aut"},{"role":"aut","given":"Kaiji","roleDisplay":"VerfasserIn","family":"Fan","display":"Fan, Kaiji"},{"display":"Sauer, Carolin M.","family":"Sauer","roleDisplay":"VerfasserIn","given":"Carolin M.","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Ludwig, Nils","family":"Ludwig","given":"Nils","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Winter","display":"Winter, Christof","given":"Christof","role":"aut"},{"role":"aut","given":"Stefan","family":"Enssle","display":"Enssle, Stefan","roleDisplay":"VerfasserIn"},{"family":"Li","display":"Li, Suqi","roleDisplay":"VerfasserIn","given":"Suqi","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Perl","display":"Perl, Markus","given":"Markus","role":"aut"},{"role":"aut","given":"André","roleDisplay":"VerfasserIn","family":"Görgens","display":"Görgens, André"},{"role":"aut","given":"Tobias","roleDisplay":"VerfasserIn","family":"Haas","display":"Haas, Tobias"},{"role":"aut","given":"Erik Thiele","family":"Orberg","display":"Orberg, Erik Thiele","roleDisplay":"VerfasserIn"},{"given":"Sascha","role":"aut","display":"Göttert, Sascha","family":"Göttert","roleDisplay":"VerfasserIn"},{"family":"Wölfel","display":"Wölfel, Catherine","roleDisplay":"VerfasserIn","role":"aut","given":"Catherine"},{"roleDisplay":"VerfasserIn","display":"Engleitner, Thomas","family":"Engleitner","given":"Thomas","role":"aut"},{"display":"Cortés-Ciriano, Isidro","family":"Cortés-Ciriano","roleDisplay":"VerfasserIn","role":"aut","given":"Isidro"},{"given":"Roland","role":"aut","roleDisplay":"VerfasserIn","display":"Rad, Roland","family":"Rad"},{"given":"Wolfgang","role":"aut","display":"Herr, Wolfgang","family":"Herr","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Giebel, Bernd","family":"Giebel","role":"aut","given":"Bernd"},{"roleDisplay":"VerfasserIn","display":"Ruland, Jürgen","family":"Ruland","role":"aut","given":"Jürgen"},{"given":"Florian","role":"aut","roleDisplay":"VerfasserIn","family":"Bassermann","display":"Bassermann, Florian"},{"roleDisplay":"VerfasserIn","display":"Coch, Christoph","family":"Coch","role":"aut","given":"Christoph"},{"family":"Hartmann","display":"Hartmann, Gunther","roleDisplay":"VerfasserIn","given":"Gunther","role":"aut"},{"role":"aut","given":"Hendrik","roleDisplay":"VerfasserIn","display":"Poeck, Hendrik","family":"Poeck"}],"recId":"1879092662","language":["eng"],"id":{"eki":["1879092662"],"doi":["10.1016/j.xcrm.2023.101171"]},"physDesc":[{"extent":"25 S."}]} 
SRT |a HEIDEGGERSTARGETINGN1920 

Ähnliche Einträge