Characterization of obesity in severe asthma in the German Asthma Net
Background - Asthma is increasingly recognized as heterogeneous, characterized by different endotypes, with obesity not only a distinct phenotype but a risk factor for severe asthma. - Objective - We sought to understand the associations of obesity with relevant parameters of severe asthma, includin...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 2023
|
| In: |
The journal of allergy and clinical immunology. In practice
Year: 2023, Jahrgang: 11, Heft: 11, Pages: 3417-3424, e1-e3 |
| ISSN: | 2213-2201 |
| DOI: | 10.1016/j.jaip.2023.06.049 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jaip.2023.06.049 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2213219823007146 
|
| Verfasserangaben: | Christina Bal, Dr Med, Wolfgang Pohl, Dr Med, Katrin Milger, Dr Med, Dirk Skowasch, Dr Med, Christian Schulz, Dr Med, Monika Gappa, Dr Med, Cordula Koerner-Rettberg, Dr Med, Margret Jandl, Dr Med, Olaf Schmidt, Dr Med, Sonja Zehetmayer, Mag, Christian Taube, Dr Med, Eckard Hamelmann, Dr Med, Roland Buhl, Dr Med, Stephanie Korn, Dr Med, and Marco Idzko, Dr Med; on behalf of the German Asthma Net (GAN) study group |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1879394103 | ||
| 003 | DE-627 | ||
| 005 | 20240307025624.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240129s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jaip.2023.06.049 |2 doi | |
| 035 | |a (DE-627)1879394103 | ||
| 035 | |a (DE-599)KXP1879394103 | ||
| 035 | |a (OCoLC)1425207368 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bal, Christina |e VerfasserIn |0 (DE-588)1263024807 |0 (DE-627)181100735X |4 aut | |
| 245 | 1 | 0 | |a Characterization of obesity in severe asthma in the German Asthma Net |c Christina Bal, Dr Med, Wolfgang Pohl, Dr Med, Katrin Milger, Dr Med, Dirk Skowasch, Dr Med, Christian Schulz, Dr Med, Monika Gappa, Dr Med, Cordula Koerner-Rettberg, Dr Med, Margret Jandl, Dr Med, Olaf Schmidt, Dr Med, Sonja Zehetmayer, Mag, Christian Taube, Dr Med, Eckard Hamelmann, Dr Med, Roland Buhl, Dr Med, Stephanie Korn, Dr Med, and Marco Idzko, Dr Med; on behalf of the German Asthma Net (GAN) study group |
| 264 | 1 | |c November 2023 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar 4 July 2023, Version des Artikels 7 November 2023 | ||
| 500 | |a Gesehen am 29.01.2024 | ||
| 520 | |a Background - Asthma is increasingly recognized as heterogeneous, characterized by different endotypes, with obesity not only a distinct phenotype but a risk factor for severe asthma. - Objective - We sought to understand the associations of obesity with relevant parameters of severe asthma, including asthma control, disease burden, and lung function. - Methods - The German Asthma Net registry is a multicenter international real-life registry capturing long-term follow-up data. This analysis included 2213 patients (52 ± 16 years, 58% female, 29% with obesity [body mass index ≥30 kg/m2], 4.2 ± 4.3 exacerbations/year). The primary analysis assessed relationships between BMI and variables through univariate tests, followed by a multiple regression model. Secondary outcomes regarded clinically relevant variables in relation to weight groups. - Results - Patients with obesity were more frequently female, more likely to have depression and gastroesophageal reflux, and suffered from worse asthma control, lower quality of life, reduced static lung volumes, more pronounced hypoxemia, and higher blood neutrophil counts, all statistically significant. Blood eosinophils, exhaled nitric oxide, and total IgE were independent of obesity. In the multiple regression analysis, obesity was significantly associated with more frequent reflux and depression, reduced static lung function values, older age, poor asthma control, and long-acting muscarinic antagonist therapy, and inversely associated with bronchiectasis and nonsmoking status. - Conclusion - In this large, well-characterized cohort, we identified the association of obesity with a significantly higher disease burden and a similar portfolio of inflammation type 2 markers in patients with and without obesity; therefore, patients with obesity seem similarly eligible for the treatment with biologics targeting these disease endotypes. | ||
| 650 | 4 | |a Asthma control | |
| 650 | 4 | |a Biomarker | |
| 650 | 4 | |a BMI | |
| 650 | 4 | |a Comorbidities | |
| 650 | 4 | |a Exacerbations | |
| 650 | 4 | |a Lung function | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Registry | |
| 650 | 4 | |a Severe asthma | |
| 700 | 1 | |a Pohl, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Milger, Katrin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Skowasch, Dirk |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schulz, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gappa, Monika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koerner-Rettberg, Cordula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jandl, Margret |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmidt, Olaf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zehetmayer, Sonja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Taube, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hamelmann, Eckard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buhl, Roland |e VerfasserIn |4 aut | |
| 700 | 1 | |a Korn, Stephanie |d 1980- |e VerfasserIn |0 (DE-588)131754483 |0 (DE-627)513603298 |0 (DE-576)298718855 |4 aut | |
| 700 | 1 | |a Idzko, Marco |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of allergy and clinical immunology. In practice |d Amsterdam [u.a.] : Elsevier, 2013 |g 11(2023), 11 vom: Nov., Seite 3417-3424, e1-e3 |h Online-Ressource |w (DE-627)757132758 |w (DE-600)2728366-5 |w (DE-576)392331748 |x 2213-2201 |7 nnas |a Characterization of obesity in severe asthma in the German Asthma Net |
| 773 | 1 | 8 | |g volume:11 |g year:2023 |g number:11 |g month:11 |g pages:3417-3424, e1-e3 |g extent:11 |a Characterization of obesity in severe asthma in the German Asthma Net |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jaip.2023.06.049 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2213219823007146 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240129 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 131754483 |a Korn, Stephanie |m 131754483:Korn, Stephanie |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PK131754483 |e 950000PK131754483 |e 950900PK131754483 |e 50000PK131754483 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 14 | ||
| 999 | |a KXP-PPN1879394103 |e 4471838946 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"partname":"In practice","title":"The journal of allergy and clinical immunology","title_sort":"journal of allergy and clinical immunology"}],"recId":"757132758","language":["eng"],"disp":"Characterization of obesity in severe asthma in the German Asthma NetThe journal of allergy and clinical immunology. In practice","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 13.12.13"],"part":{"volume":"11","text":"11(2023), 11 vom: Nov., Seite 3417-3424, e1-e3","extent":"11","year":"2023","issue":"11","pages":"3417-3424, e1-e3"},"titleAlt":[{"title":"The journal of allergy and clinical immunology / In practice"}],"pubHistory":["1.2013 -"],"id":{"eki":["757132758"],"zdb":["2728366-5"],"issn":["2213-2201"]},"origin":[{"dateIssuedDisp":"2013-","publisher":"Elsevier","dateIssuedKey":"2013","publisherPlace":"Amsterdam [u.a.]"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"11 S."}],"name":{"displayForm":["Christina Bal, Dr Med, Wolfgang Pohl, Dr Med, Katrin Milger, Dr Med, Dirk Skowasch, Dr Med, Christian Schulz, Dr Med, Monika Gappa, Dr Med, Cordula Koerner-Rettberg, Dr Med, Margret Jandl, Dr Med, Olaf Schmidt, Dr Med, Sonja Zehetmayer, Mag, Christian Taube, Dr Med, Eckard Hamelmann, Dr Med, Roland Buhl, Dr Med, Stephanie Korn, Dr Med, and Marco Idzko, Dr Med; on behalf of the German Asthma Net (GAN) study group"]},"id":{"doi":["10.1016/j.jaip.2023.06.049"],"eki":["1879394103"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"November 2023"}],"language":["eng"],"recId":"1879394103","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Online verfügbar 4 July 2023, Version des Artikels 7 November 2023","Gesehen am 29.01.2024"],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Bal, Christina","given":"Christina","family":"Bal"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Pohl, Wolfgang","given":"Wolfgang","family":"Pohl"},{"display":"Milger, Katrin","roleDisplay":"VerfasserIn","role":"aut","family":"Milger","given":"Katrin"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Skowasch, Dirk","given":"Dirk","family":"Skowasch"},{"given":"Christian","family":"Schulz","role":"aut","display":"Schulz, Christian","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Gappa, Monika","given":"Monika","family":"Gappa"},{"given":"Cordula","family":"Koerner-Rettberg","role":"aut","display":"Koerner-Rettberg, Cordula","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Jandl, Margret","given":"Margret","family":"Jandl"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schmidt, Olaf","given":"Olaf","family":"Schmidt"},{"given":"Sonja","family":"Zehetmayer","role":"aut","roleDisplay":"VerfasserIn","display":"Zehetmayer, Sonja"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Taube, Christian","given":"Christian","family":"Taube"},{"family":"Hamelmann","given":"Eckard","display":"Hamelmann, Eckard","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Buhl, Roland","given":"Roland","family":"Buhl"},{"given":"Stephanie","family":"Korn","role":"aut","display":"Korn, Stephanie","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Idzko, Marco","role":"aut","family":"Idzko","given":"Marco"}],"title":[{"title_sort":"Characterization of obesity in severe asthma in the German Asthma Net","title":"Characterization of obesity in severe asthma in the German Asthma Net"}]} | ||
| SRT | |a BALCHRISTICHARACTERI2023 | ||