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The theranostic optimization of PSMA-GCK01 does not compromise the imaging characteristics of [99mTc]Tc-PSMA-GCK01 compared to dedicated diagnostic [99mTc]Tc-EDDA/HYNIC-iPSMA in prostate cancer

Radiolabeled PSMA-ligands play a major role in today’s nuclear medicine. Since approval of [177Lu]Lu-PSMA-617 for therapy of metastatic prostate cancer, availability of 177Lu became bottleneck of supply due to the high demand. Recently, a theranostic PSMA-ligand, PSMA-GCK01, was developed which can...

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Hauptverfasser: Mamlins, Eduards (VerfasserIn) , Scharbert, Lara (VerfasserIn) , Cardinale, Jens (VerfasserIn) , Krotov, Maria (VerfasserIn) , Winter, Erik (VerfasserIn) , Rathke, Hendrik (VerfasserIn) , Strodel, Birgit (VerfasserIn) , Ankrah, Alfred O. (VerfasserIn) , Sathekge, Mike (VerfasserIn) , Haberkorn, Uwe (VerfasserIn) , Kratochwil, Clemens (VerfasserIn) , Giesel, Frederik L. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 08 December 2023
In: Molecular imaging & biology
Year: 2023, Pages: 1-9
ISSN:1860-2002
DOI:10.1007/s11307-023-01881-y
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11307-023-01881-y
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s11307-023-01881-y
Volltext
Verfasserangaben:Eduards Mamlins, Lara Scharbert, Jens Cardinale, Maria Krotov, Erik Winter, Hendrik Rathke, Birgit Strodel, Alfred O. Ankrah, Mike Sathekge, Uwe Haberkorn, Clemens Kratochwil, Frederik L. Giesel
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Zusammenfassung:Radiolabeled PSMA-ligands play a major role in today’s nuclear medicine. Since approval of [177Lu]Lu-PSMA-617 for therapy of metastatic prostate cancer, availability of 177Lu became bottleneck of supply due to the high demand. Recently, a theranostic PSMA-ligand, PSMA-GCK01, was developed which can be labeled either diagnostically with 99mTc or therapeutically with 188Re with both nuclides available from well-known generator systems. This novel tracer might aid to overcome aforementioned supply limitations. In this investigation, the biodistribution and general imaging characteristics of [99mTc]Tc-PSMA-GCK01 were compared with the diagnostic reference compound [99mTc]Tc-EDDA/HYNIC-iPSMA in patients with advanced stage prostate cancer. In addition, the binding of both ligands to PSMA was analyzed at the molecular level using molecular docking.
Beschreibung:Gesehen am 30.01.2024
Beschreibung:Online Resource
ISSN:1860-2002
DOI:10.1007/s11307-023-01881-y

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