Minimally invasive versus open pancreatoduodenectomy for pancreatic ductal adenocarcinoma: Individual patient data meta-analysis of randomized trials
Objective - Assessment of minimally invasive pancreatoduodenectomy (MIPD) in patients with pancreatic ductal adenocarcinoma (PDAC) is scarce and limited to non-randomized studies. This study aimed to compare oncological and surgical outcomes after MIPD compared to open pancreatoduodenectomy (OPD) fo...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 August 2023
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| In: |
European journal of surgical oncology
Year: 2023, Jahrgang: 49, Heft: 8, Pages: 1351-1361 |
| ISSN: | 1532-2157 |
| DOI: | 10.1016/j.ejso.2023.03.227 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ejso.2023.03.227 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0748798323004274 
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| Verfasserangaben: | Bas A. Uijterwijk, Kongyuan Wei, Meidai Kasai, Benedetto Ielpo, Jony van Hilst, Palanivelu Chinnusamy, Daniel H. L. Lemmers, Fernando Burdio, Palanisamy Senthilnathan, Marc G. Besselink, Mohammed Abu Hilal, Renyi Qin |
MARC
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| 245 | 1 | 0 | |a Minimally invasive versus open pancreatoduodenectomy for pancreatic ductal adenocarcinoma |b Individual patient data meta-analysis of randomized trials |c Bas A. Uijterwijk, Kongyuan Wei, Meidai Kasai, Benedetto Ielpo, Jony van Hilst, Palanivelu Chinnusamy, Daniel H. L. Lemmers, Fernando Burdio, Palanisamy Senthilnathan, Marc G. Besselink, Mohammed Abu Hilal, Renyi Qin |
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| 520 | |a Objective - Assessment of minimally invasive pancreatoduodenectomy (MIPD) in patients with pancreatic ductal adenocarcinoma (PDAC) is scarce and limited to non-randomized studies. This study aimed to compare oncological and surgical outcomes after MIPD compared to open pancreatoduodenectomy (OPD) for patients after resectable PDAC from published randomized controlled trials (RCTs). - Methods - A systematic review was performed to identify RCTs comparing MIPD and OPD including PDAC (Jan 2015-July 2021). Individual data of patients with PDAC were requested. Primary outcomes were R0 rate and lymph node yield. Secondary outcomes were blood-loss, operation time, major complications, hospital stay and 90-day mortality. - Results - Overall, 4 RCTs (all addressed laparoscopic MIPD) with 275 patients with PDAC were included. In total, 128 patients underwent laparoscopic MIPD and 147 patients underwent OPD. The R0 rate (risk difference(RD) −1%, P = 0.740) and lymph node yield (mean difference(MD) +1.55, P = 0.305) were comparable between laparoscopic MIPD and OPD. Laparoscopic MIPD was associated with less perioperative blood-loss (MD -91ml, P = 0.026), shorter length of hospital stay (MD -3.8 days, P = 0.044), while operation time was longer (MD +98.5 min, P = 0.003). Major complications (RD -11%, P = 0.302) and 90-day mortality (RD -2%, P = 0.328) were comparable between laparoscopic MIPD and OPD. - Conclusions - This individual patient data meta-analysis of MIPD versus OPD in patients with resectable PDAC suggests that laparoscopic MIPD is non-inferior regarding radicality, lymph node yield, major complications and 90-day mortality and is associated with less blood loss, shorter hospital stay, and longer operation time. The impact on long-term survival and recurrence should be studied in RCTs including robotic MIPD. | ||
| 650 | 4 | |a HPB surgery | |
| 650 | 4 | |a Minimally invasive pancreatoduodenectomy | |
| 650 | 4 | |a Minimally invasive surgery | |
| 650 | 4 | |a Open pancreatoduodenectomy | |
| 650 | 4 | |a Pancreatic ductal adenocarcinoma | |
| 650 | 4 | |a Pancreatoduodenectomy | |
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| 700 | 1 | |a Abu Hilal, Mohammed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Qin, Renyi |e VerfasserIn |4 aut | |
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