Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation
The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independ...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2024
|
| In: |
Bone marrow transplantation
Year: 2024, Volume: 59, Pages: 217–223 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/s41409-023-02139-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41409-023-02139-5 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41409-023-02139-5 
|
| Author Notes: | Alexandros Spyridonidis, Myriam Labopin, Tobias Gedde-Dahl, Arnold Ganser, Matthias Stelljes, Charles Craddock, Eva Maria Wagner-Drouet, Jurjen Versluis, Thomas Schroeder, Igor Wolfgang Blau, Gerald G. Wulf, Peter Dreger, Gitte Olesen, Henrik Sengeloev, Nicolaus Kröger, Victoria Potter, Edouard Forcade, Jakob Passweg, Régis Peffault de Latour, Johan Maertens, Keith M.O. Wilson, Jean Henri Bourhis, Juergen Finke, Eolia Brissot, Ali Bazarbachi, Sebastian Giebel, Bipin P. Savani, Arnon Nagler, Fabio Ciceri and Mohamad Mohty |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1879939339 | ||
| 003 | DE-627 | ||
| 005 | 20250522233349.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240205s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41409-023-02139-5 |2 doi | |
| 035 | |a (DE-627)1879939339 | ||
| 035 | |a (DE-599)KXP1879939339 | ||
| 035 | |a (OCoLC)1425200288 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Spyridonidis, Alexandros |d 1968- |e VerfasserIn |0 (DE-588)115781668 |0 (DE-627)077468147 |0 (DE-576)290073677 |4 aut | |
| 245 | 1 | 0 | |a Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation |c Alexandros Spyridonidis, Myriam Labopin, Tobias Gedde-Dahl, Arnold Ganser, Matthias Stelljes, Charles Craddock, Eva Maria Wagner-Drouet, Jurjen Versluis, Thomas Schroeder, Igor Wolfgang Blau, Gerald G. Wulf, Peter Dreger, Gitte Olesen, Henrik Sengeloev, Nicolaus Kröger, Victoria Potter, Edouard Forcade, Jakob Passweg, Régis Peffault de Latour, Johan Maertens, Keith M.O. Wilson, Jean Henri Bourhis, Juergen Finke, Eolia Brissot, Ali Bazarbachi, Sebastian Giebel, Bipin P. Savani, Arnon Nagler, Fabio Ciceri and Mohamad Mohty |
| 264 | 1 | |c 2024 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 17 November 2023 | ||
| 500 | |a Gesehen am 05.02.2024 | ||
| 520 | |a The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively), and examined the validity of the TCI category in predicting early non-relapse mortality (NRM), 2-year NRM and relapse (REL). In the unadjusted comparison, the TCI index provided a significant risk stratification for d100 and d180 NRM, NRM and REL risk. In the multivariate analysis adjusted for significant variables, there was an independent association of TCI with early NRM, NRM and REL. In summary, we confirm in contemporary treated patients that TCI reflects the conditioning regimen related morbidity and anti-leukemic efficacy satisfactorily and across other established prognostic factors. | ||
| 650 | 4 | |a Stem-cell research | |
| 650 | 4 | |a Therapeutics | |
| 700 | 1 | |a Labopin, Myriam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gedde-Dahl, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ganser, Arnold |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stelljes, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Craddock, Charles |e VerfasserIn |0 (DE-588)1208708767 |0 (DE-627)1695264614 |4 aut | |
| 700 | 1 | |a Wagner-Drouet, Eva Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Versluis, Jurjen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schroeder, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blau, Igor Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wulf, Gerald G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dreger, Peter |e VerfasserIn |0 (DE-588)1028891881 |0 (DE-627)732699894 |0 (DE-576)376320966 |4 aut | |
| 700 | 1 | |a Olesen, Gitte |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sengeloev, Henrik |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Kröger, Nicolaus |d 1959- |e VerfasserIn |0 (DE-588)112156533 |0 (DE-627)477107354 |0 (DE-576)167115103 |4 aut | |
| 700 | 1 | |a Potter, Victoria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Forcade, Edouard |e VerfasserIn |4 aut | |
| 700 | 1 | |8 3\p |a Passweg, Jakob R. |d 1959- |e VerfasserIn |0 (DE-588)1077588011 |0 (DE-627)837268265 |0 (DE-576)446392251 |4 aut | |
| 700 | 1 | |a de Latour, Régis Peffault |e VerfasserIn |4 aut | |
| 700 | 1 | |8 4\p |a Maertens, Johan |e VerfasserIn |0 (DE-588)1286965314 |0 (DE-627)1843525259 |4 aut | |
| 700 | 1 | |a Wilson, Keith M. O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bourhis, Jean Henri |e VerfasserIn |4 aut | |
| 700 | 1 | |8 5\p |a Finke, Jürgen |e VerfasserIn |0 (DE-588)1096178028 |0 (DE-627)856561029 |0 (DE-576)467887586 |4 aut | |
| 700 | 1 | |a Brissot, Eolia |e VerfasserIn |4 aut | |
| 700 | 1 | |8 6\p |a Bazarbachi, Ali |e VerfasserIn |0 (DE-588)1189768747 |0 (DE-627)1668480697 |4 aut | |
| 700 | 1 | |a Giebel, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Savani, Bipin P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nagler, Arnon |e VerfasserIn |4 aut | |
| 700 | 1 | |8 7\p |a Ciceri, Fabio |e VerfasserIn |0 (DE-588)1260305732 |0 (DE-627)1922854816 |4 aut | |
| 700 | 1 | |8 8\p |a Mohty, Mohamad |e VerfasserIn |0 (DE-588)120355768X |0 (DE-627)1688532021 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Bone marrow transplantation |d London : Springer Nature, 1997 |g 59(2024), Seite 217–223 |h Online-Ressource |w (DE-627)320433366 |w (DE-600)2004030-1 |w (DE-576)091012996 |x 1476-5365 |7 nnas |a Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation |
| 773 | 1 | 8 | |g volume:59 |g year:2024 |g pages:217–223 |g extent:7 |a Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41409-023-02139-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41409-023-02139-5 |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 5\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 6\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 7\p |a cgwrk |d 20250505 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 8\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20240205 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1028891881 |a Dreger, Peter |m 1028891881:Dreger, Peter |d 910000 |d 910100 |e 910000PD1028891881 |e 910100PD1028891881 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 999 | |a KXP-PPN1879939339 |e 4476301851 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"Alexandros","family":"Spyridonidis","display":"Spyridonidis, Alexandros"},{"role":"aut","given":"Myriam","family":"Labopin","display":"Labopin, Myriam"},{"role":"aut","family":"Gedde-Dahl","display":"Gedde-Dahl, Tobias","given":"Tobias"},{"role":"aut","family":"Ganser","display":"Ganser, Arnold","given":"Arnold"},{"display":"Stelljes, Matthias","family":"Stelljes","given":"Matthias","role":"aut"},{"given":"Charles","family":"Craddock","display":"Craddock, Charles","role":"aut"},{"given":"Eva Maria","display":"Wagner-Drouet, Eva Maria","family":"Wagner-Drouet","role":"aut"},{"role":"aut","given":"Jurjen","family":"Versluis","display":"Versluis, Jurjen"},{"role":"aut","display":"Schroeder, Thomas","family":"Schroeder","given":"Thomas"},{"family":"Blau","display":"Blau, Igor Wolfgang","given":"Igor Wolfgang","role":"aut"},{"role":"aut","family":"Wulf","display":"Wulf, Gerald G.","given":"Gerald G."},{"role":"aut","given":"Peter","family":"Dreger","display":"Dreger, Peter"},{"given":"Gitte","family":"Olesen","display":"Olesen, Gitte","role":"aut"},{"given":"Henrik","display":"Sengeloev, Henrik","family":"Sengeloev","role":"aut"},{"role":"aut","family":"Kröger","display":"Kröger, Nicolaus","given":"Nicolaus"},{"given":"Victoria","display":"Potter, Victoria","family":"Potter","role":"aut"},{"role":"aut","given":"Edouard","family":"Forcade","display":"Forcade, Edouard"},{"given":"Jakob R.","family":"Passweg","display":"Passweg, Jakob R.","role":"aut"},{"family":"de Latour","display":"de Latour, Régis Peffault","given":"Régis Peffault","role":"aut"},{"role":"aut","given":"Johan","display":"Maertens, Johan","family":"Maertens"},{"role":"aut","family":"Wilson","display":"Wilson, Keith M. O.","given":"Keith M. O."},{"given":"Jean Henri","display":"Bourhis, Jean Henri","family":"Bourhis","role":"aut"},{"role":"aut","family":"Finke","display":"Finke, Jürgen","given":"Jürgen"},{"role":"aut","display":"Brissot, Eolia","family":"Brissot","given":"Eolia"},{"role":"aut","given":"Ali","display":"Bazarbachi, Ali","family":"Bazarbachi"},{"role":"aut","given":"Sebastian","family":"Giebel","display":"Giebel, Sebastian"},{"role":"aut","display":"Savani, Bipin P.","family":"Savani","given":"Bipin P."},{"given":"Arnon","family":"Nagler","display":"Nagler, Arnon","role":"aut"},{"role":"aut","given":"Fabio","family":"Ciceri","display":"Ciceri, Fabio"},{"display":"Mohty, Mohamad","family":"Mohty","given":"Mohamad","role":"aut"}],"physDesc":[{"extent":"7 S."}],"title":[{"title":"Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation","title_sort":"Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation"}],"relHost":[{"disp":"Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantationBone marrow transplantation","note":["Gesehen am 17.01.25"],"pubHistory":["Nachgewiesen 19.1997 -"],"recId":"320433366","id":{"eki":["320433366"],"issn":["1476-5365"],"zdb":["2004030-1"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"origin":[{"dateIssuedKey":"1997","publisher":"Springer Nature ; Macmillan ; Nature Publishing Group","publisherPlace":"London ; Basingstoke ; London","dateIssuedDisp":"1997-"}],"part":{"volume":"59","year":"2024","extent":"7","pages":"217–223","text":"59(2024), Seite 217–223"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Bone marrow transplantation","title":"Bone marrow transplantation"}]}],"id":{"eki":["1879939339"],"doi":["10.1038/s41409-023-02139-5"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"origin":[{"dateIssuedDisp":"2024","dateIssuedKey":"2024"}],"name":{"displayForm":["Alexandros Spyridonidis, Myriam Labopin, Tobias Gedde-Dahl, Arnold Ganser, Matthias Stelljes, Charles Craddock, Eva Maria Wagner-Drouet, Jurjen Versluis, Thomas Schroeder, Igor Wolfgang Blau, Gerald G. Wulf, Peter Dreger, Gitte Olesen, Henrik Sengeloev, Nicolaus Kröger, Victoria Potter, Edouard Forcade, Jakob Passweg, Régis Peffault de Latour, Johan Maertens, Keith M.O. Wilson, Jean Henri Bourhis, Juergen Finke, Eolia Brissot, Ali Bazarbachi, Sebastian Giebel, Bipin P. Savani, Arnon Nagler, Fabio Ciceri and Mohamad Mohty"]},"recId":"1879939339","note":["Online veröffentlicht: 17 November 2023","Gesehen am 05.02.2024"]} | ||
| SRT | |a SPYRIDONIDVALIDATION2024 | ||