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Long-term generator replacement experience in hypoglossal nerve stimulator therapy recipients with CPAP-intolerant obstructive sleep apnea: orignal research

Abstract Objective In the last decade, hypoglossal nerve stimulation (HNS) has emerged as a therapeutic alternative for patients with obstructive sleep apnea. The original clinical trial cohorts are entering the phase of expected battery depletion (8-12 years). This study aimed to examine the surgic...

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Main Authors: Magaña, Linda (Author) , Strollo, Patrick J., Jr. (Author) , Steffen, Armin (Author) , Ravesloot, Madeline (Author) , van Maanen, Peter (Author) , Harrison, Christine (Author) , Maurer, Joachim T. (Author) , Soose, Ryan J. (Author)
Format: Article (Journal)
Language:English
Published: 01 April 2023
In: Otolaryngology - head and neck surgery
Year: 2023, Volume: 169, Issue: 4, Pages: 1064-1069
ISSN:1097-6817
DOI:10.1002/ohn.340
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/ohn.340
Verlag, lizenzpflichtig, Volltext: https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/ohn.340
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Author Notes:Linda C Magaña, Patrick J Strollo, Armin Steffen, Madeline Ravesloot, Peter van Maanen, Christine Harrison, Joachim T Maurer, Ryan J Soose
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Summary:Abstract Objective In the last decade, hypoglossal nerve stimulation (HNS) has emerged as a therapeutic alternative for patients with obstructive sleep apnea. The original clinical trial cohorts are entering the phase of expected battery depletion (8-12 years). This study aimed to examine the surgical experience with implantable pulse generator (IPG) replacements and the associated long-term therapy outcomes. Study Design Retrospective analysis of patients from the original clinical trial databases (STAR, German post-market) who were followed in the ongoing ADHERE registry. Setting International multicenter HNS registry. Methods The ADHERE registry and clinical trial databases were cross-referenced to identify the serial numbers of IPGs that were replaced. Data collection included demographics, apnea-hypopnea index (AHI), therapy use, operative times, and adverse events. Results Fourteen patients underwent IPG replacement 8.3 ± 1.1 years after their initial implantation. Body mass index was unchanged between the original implant and IPG replacement (29 ± 4 vs 28 ± 2 kg/m2, p = .50).
Item Description:Gesehen am 05.02.2024
Physical Description:Online Resource
ISSN:1097-6817
DOI:10.1002/ohn.340

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