Therapeutic drug monitoring of osimertinib in non-small cell lung cancer and short bowel syndrome: a case report
Short bowel syndrome (SBS) following extensive intestinal resection is often characterized by impaired absorption of orally administered drugs, including tyrosine kinase inhibitors (TKI). We report the case of a patient with EGFR-mutated non-small cell lung carcinoma treated with 80 mg/day of the TK...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2024
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| In: |
British journal of clinical pharmacology
Year: 2024, Jahrgang: 90, Heft: 1, Pages: 344-349 |
| ISSN: | 1365-2125 |
| DOI: | 10.1111/bcp.15924 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/bcp.15924 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bcp.15924 
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| Verfasserangaben: | Rémi Longuespée, Julia Kunz, Margaux Fresnais, Kathrin I. Foerster, Jürgen Burhenne, Michael Thomas, Daniel Kazdal, Albrecht Stenzinger, Petros Christopoulos, Walter E. Haefeli |
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| 520 | |a Short bowel syndrome (SBS) following extensive intestinal resection is often characterized by impaired absorption of orally administered drugs, including tyrosine kinase inhibitors (TKI). We report the case of a patient with EGFR-mutated non-small cell lung carcinoma treated with 80 mg/day of the TKI osimertinib who achieved partial response of the tumour, but was subsequently subjected to a double-barrelled jejunostomy due to ileus. Due to the development of SBS after the bypass surgery, plasma concentrations of osimertinib were monitored using mass spectrometry. The therapeutic drug monitoring confirmed a malabsorption of osimertinib in the patient (108 ng/mL, which is below the 5th percentile of the expected plasma concentration) and was useful to guide adjustments of TKI dosing in order to achieve adequate blood levels (161 ng/mL after increase of the dose to 120 mg/day) in order to maintain tumour control. | ||
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