Caspase-8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice
The gut has a specific vascular barrier that controls trafficking of antigens and microbiota into the bloodstream. However, the molecular mechanisms regulating the maintenance of this vascular barrier remain elusive. Here, we identified Caspase-8 as a pro-survival factor in mature intestinal endothe...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 May 2022
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| In: |
EMBO molecular medicine
Year: 2022, Jahrgang: 14, Heft: 6, Pages: 1-21 |
| ISSN: | 1757-4684 |
| DOI: | 10.15252/emmm.202114121 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.15252/emmm.202114121 Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.15252/emmm.202114121 
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| Verfasserangaben: | Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Géza Scherman, Lena Erkert, Jay V Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Köhler, Hellmut G Augustin, Christoph Becker, Thomas Schmidt and Carmen Ruiz de Almodóvar |
MARC
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| 245 | 1 | 0 | |a Caspase-8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice |c Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Géza Scherman, Lena Erkert, Jay V Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Köhler, Hellmut G Augustin, Christoph Becker, Thomas Schmidt and Carmen Ruiz de Almodóvar |
| 246 | 3 | 3 | |a Caspase-eight in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice |
| 264 | 1 | |c 2 May 2022 | |
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| 520 | |a The gut has a specific vascular barrier that controls trafficking of antigens and microbiota into the bloodstream. However, the molecular mechanisms regulating the maintenance of this vascular barrier remain elusive. Here, we identified Caspase-8 as a pro-survival factor in mature intestinal endothelial cells that is required to actively maintain vascular homeostasis in the small intestine in an organ-specific manner. In particular, we find that deletion of Caspase-8 in endothelial cells results in small intestinal hemorrhages and bowel inflammation, while all other organs remained unaffected. We also show that Caspase-8 seems to be particularly needed in lymphatic endothelial cells to maintain gut homeostasis. Our work demonstrates that endothelial cell dysfunction, leading to the breakdown of the gut-vascular barrier, is an active driver of chronic small intestinal inflammation, highlighting the role of the intestinal vasculature as a safeguard of organ function. | ||
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