Prevalence of non-alcoholic fatty liver disease in the Russian Ural Eye and Medical Study and the Ural Very Old Study
Information about prevalence and associated factors of non-alcoholic fatty liver disease (NAFLD) has been scarce for the Russian, Eastern European and Central Asian world region. We assessed prevalence and associated factors of NAFLD in two population-based studies (Ural Eye and Medical Study (UEMS)...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 May 2022
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| In: |
Scientific reports
Year: 2022, Jahrgang: 12, Pages: 1-9 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-022-12004-y |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-022-12004-y Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41598-022-12004-y 
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| Verfasserangaben: | Mukharram M. Bikbov, Timur R. Gilmanshin, Rinat M. Zainullin, Gyulli M. Kazakbaeva, Ellina M. Iakupova, Albina A. Fakhretdinova, Azaliia M. Tuliakova, Songhomitra Panda-Jonas, Leisan I. Gilemzianova, Dinar A. Khakimov, Liana A. Miniazeva and Jost B. Jonas |
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| 245 | 1 | 0 | |a Prevalence of non-alcoholic fatty liver disease in the Russian Ural Eye and Medical Study and the Ural Very Old Study |c Mukharram M. Bikbov, Timur R. Gilmanshin, Rinat M. Zainullin, Gyulli M. Kazakbaeva, Ellina M. Iakupova, Albina A. Fakhretdinova, Azaliia M. Tuliakova, Songhomitra Panda-Jonas, Leisan I. Gilemzianova, Dinar A. Khakimov, Liana A. Miniazeva and Jost B. Jonas |
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| 520 | |a Information about prevalence and associated factors of non-alcoholic fatty liver disease (NAFLD) has been scarce for the Russian, Eastern European and Central Asian world region. We assessed prevalence and associated factors of NAFLD in two population-based studies (Ural Eye and Medical Study (UEMS), Ural Very Old Study (UVOS)), which were conducted in rural and urban regions in Bashkortostan/Russia and included participants aged 40 + years and 85 + years, respectively. Defining NAFLD by an absence of regular alcohol consumption, and by abnormally high alanine transaminase (ALT) and aspartate transaminase (AST) concentrations or an AST/ALT ratio of > 1.0, 2341 out of 5852 UEMS participants (40.0%; 95% confidence intervals (CI) 38.8, 41.3) had NAFLD. A higher NAFLD prevalence correlated (multivariable analysis) with older age (odds ratio (OR) 1.02; 95%CI 1.01, 1.03; P < 0.001), female sex (OR 1.87; 95%CI 1.58, 2.21; P < 0.001), higher waist-hip circumference ratio (OR 2.64; 95%CI 1.11, 6.27; P = 0.03), lower depression score (OR 0.98; 95%CI 0.96, 0.999; P = 0.04), higher serum concentrations of creatinine (OR 1.004; 95%CI 1.000, 1.008; P = 0.03) and bilirubine (OR 1.009; 95%CI 1.002, 1.015; P = 0.008), lower prothrombin index (OR 0.99; 95%CI 0.985, 0.998; P = 0.01), lower ankle-brachial index (OR 0.49; 95%CI 0.32, 0.75; P = 0.001), higher prevalence of a grain-rich diet (OR 1.88; 95%CI 1.50, 2.36; P < 0.001) and iron deficiency-related anemia (OR 1.61; 95%CI 1.13, 2.29; P = 0.009), and lower prevalence of vigorous leisure activities (OR 0.84; 95%CI 0.72, 0.99; P = 0.04). In the UVOS, NAFLD prevalence (mean: 789/1130; 69.8%; 95%CI 67.1, 72.3) was associated with female sex (OR 2.24; 95%CI 1.66, 3.01; P < 0.001), higher serum concentrations of low-density lipoproteins (OR 1.34; 95%CI 1.17, 1.55; P < 0.001), lower prothrombin index (OR 0.98; 95%CI 0.96, 0.99; P = 0.002), and lower ankle-brachial index (OR 0.03; 95%CI 0.02, 0.29; P = 0.003). The NAFLD prevalence of 40% in the UEMS and 69.8% in the UVOS corresponds to findings obtained in other world regions and shows the importance of NAFLD, including its determinants such as age, sex, waist-hip ratio, serum creatinine concentration, prothrombin index, ankle-brachial index, and lower physical activity. | ||
| 650 | 4 | |a Non-alcoholic fatty liver disease | |
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| 700 | 1 | |a Zainullin, Rinat M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kazakbaeva, Gyulli M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Iakupova, Ellina M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fakhretdinova, Albina A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tuliakova, Azaliia M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Panda-Jonas, Songhomitra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gilemzianova, Leisan I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Khakimov, Dinar A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Miniazeva, Liana A. |e VerfasserIn |4 aut | |
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