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Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder: article

Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To pro...

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Hauptverfasser: Amare, Azmeraw T. (VerfasserIn) , Thalamuthu, Anbupalam (VerfasserIn) , Schubert, Klaus Oliver (VerfasserIn) , Figge, Christian (VerfasserIn) , Fullerton, Janice M. (VerfasserIn) , Ahmed, Muktar (VerfasserIn) , Hartmann, Simon (VerfasserIn) , Papiol, Sergi (VerfasserIn) , Heilbronner, Urs (VerfasserIn) , Degenhardt, Franziska (VerfasserIn) , Tekola-Ayele, Fasil (VerfasserIn) , Hou, Liping (VerfasserIn) , Hsu, Yi-Hsiang (VerfasserIn) , Shekhtman, Tatyana (VerfasserIn) , Adli, Mazda (VerfasserIn) , Akula, Nirmala (VerfasserIn) , Akiyama, Kazufumi (VerfasserIn) , Ardau, Raffaella (VerfasserIn) , Arias, Bárbara (VerfasserIn) , Aubry, Jean-Michel (VerfasserIn) , Hasler, Roland (VerfasserIn) , Richard-Lepouriel, Hélène (VerfasserIn) , Perroud, Nader (VerfasserIn) , Backlund, Lena (VerfasserIn) , Bhattacharjee, Abesh Kumar (VerfasserIn) , Bellivier, Frank (VerfasserIn) , Benabarre, Antonio (VerfasserIn) , Bengesser, Susanne (VerfasserIn) , Biernacka, Joanna M. (VerfasserIn) , Birner, Armin (VerfasserIn) , Marie-Claire, Cynthia (VerfasserIn) , Cervantes, Pablo (VerfasserIn) , Chen, Hsi-Chung (VerfasserIn) , Chillotti, Caterina (VerfasserIn) , Cichon, Sven (VerfasserIn) , Cruceanu, Cristiana (VerfasserIn) , Czerski, Piotr M. (VerfasserIn) , Dalkner, Nina (VerfasserIn) , Del Zompo, Maria (VerfasserIn) , DePaulo, J. Raymond (VerfasserIn) , Étain, Bruno (VerfasserIn) , Jamain, Stephane (VerfasserIn) , Falkai, Peter (VerfasserIn) , Forstner, Andreas J. (VerfasserIn) , Frisen, Louise (VerfasserIn) , Frye, Mark A. (VerfasserIn) , Gard, Sébastien (VerfasserIn) , Garnham, Julie S. (VerfasserIn) , Goes, Fernando S. (VerfasserIn) , Grigoroiu-Serbanescu, Maria (VerfasserIn) , Fallgatter, Andreas J. (VerfasserIn) , Stegmaier, Sophia (VerfasserIn) , Ethofer, Thomas (VerfasserIn) , Biere, Silvia (VerfasserIn) , Petrova, Kristiyana (VerfasserIn) , Schuster, Ceylan (VerfasserIn) , Adorjan, Kristina (VerfasserIn) , Budde, Monika (VerfasserIn) , Heilbronner, Maria (VerfasserIn) , Kalman, Janos L. (VerfasserIn) , Kohshour, Mojtaba Oraki (VerfasserIn) , Reich-Erkelenz, Daniela (VerfasserIn) , Schaupp, Sabrina K. (VerfasserIn) , Schulte, Eva C. (VerfasserIn) , Senner, Fanny (VerfasserIn) , Vogl, Thomas (VerfasserIn) , Anghelescu, Ion-George (VerfasserIn) , Arolt, Volker (VerfasserIn) , Dannlowski, Udo (VerfasserIn) , Dietrich, Detlef (VerfasserIn) , Jäger, Markus (VerfasserIn) , Lang, Fabian U. (VerfasserIn) , Juckel, Georg (VerfasserIn) , Konrad, Carsten (VerfasserIn) , Reimer, Jens (VerfasserIn) , Schmauß, Max (VerfasserIn) , Schmitt, Andrea (VerfasserIn) , Spitzer, Carsten (VerfasserIn) , von Hagen, Martin (VerfasserIn) , Wiltfang, Jens (VerfasserIn) , Zimmermann, Jörg (VerfasserIn) , Andlauer, Till F. M. (VerfasserIn) , Fischer, Andre (VerfasserIn) , Bermpohl, Felix (VerfasserIn) , Ritter, Philipp (VerfasserIn) , Matura, Silke (VerfasserIn) , Gryaznova, Anna (VerfasserIn) , Falkenberg, Irina (VerfasserIn) , Yildiz, Cüneyt (VerfasserIn) , Kircher, Tilo (VerfasserIn) , Schmidt, Julia (VerfasserIn) , Koch, Marius (VerfasserIn) , Gade, Kathrin (VerfasserIn) , Trost, Sarah (VerfasserIn) , Haussleiter, Ida S. (VerfasserIn) , Lambert, Martin (VerfasserIn) , Rohenkohl, Anja C. (VerfasserIn) , Kraft, Vivien (VerfasserIn) , Grof, Paul (VerfasserIn) , Hashimoto, Ryota (VerfasserIn) , Hauser, Joanna (VerfasserIn) , Herms, Stefan (VerfasserIn) , Hoffmann, Per (VerfasserIn) , Jiménez, Esther (VerfasserIn) , Kahn, Jean-Pierre (VerfasserIn) , Kassem, Layla (VerfasserIn) , Kuo, Po-Hsiu (VerfasserIn) , Kato, Tadafumi (VerfasserIn) , Kelsoe, John (VerfasserIn) , Kittel-Schneider, Sarah (VerfasserIn) , Ferensztajn-Rochowiak, Ewa (VerfasserIn) , König, Barbara (VerfasserIn) , Kusumi, Ichiro (VerfasserIn) , Laje, Gonzalo (VerfasserIn) , Landén, Mikael (VerfasserIn) , Lavebratt, Catharina (VerfasserIn) , Leboyer, Marion (VerfasserIn) , Leckband, Susan G. (VerfasserIn) , Tortorella, Alfonso (VerfasserIn) , Manchia, Mirko (VerfasserIn) , Martinsson, Lina (VerfasserIn) , McCarthy, Michael J. (VerfasserIn) , McElroy, Susan (VerfasserIn) , Colom, Francesc (VerfasserIn) , Millischer, Vincent (VerfasserIn) , Mitjans, Marina (VerfasserIn) , Mondimore, Francis M. (VerfasserIn) , Monteleone, Palmiero (VerfasserIn) , Nievergelt, Caroline M. (VerfasserIn) , Nöthen, Markus M. (VerfasserIn) , Novák, Tomas (VerfasserIn) , O’Donovan, Claire (VerfasserIn) , Ozaki, Norio (VerfasserIn) , Pfennig, Andrea (VerfasserIn) , Pisanu, Claudia (VerfasserIn) , Potash, James B. (VerfasserIn) , Reif, Andreas (VerfasserIn) , Reininghaus, Eva (VerfasserIn) , Rouleau, Guy A. (VerfasserIn) , Rybakowski, Janusz K. (VerfasserIn) , Schalling, Martin (VerfasserIn) , Schofield, Peter R. (VerfasserIn) , Schweizer, Barbara W. (VerfasserIn) , Severino, Giovanni (VerfasserIn) , Shilling, Paul D. (VerfasserIn) , Shimoda, Katzutaka (VerfasserIn) , Simhandl, Christian (VerfasserIn) , Slaney, Claire M. (VerfasserIn) , Squassina, Alessio (VerfasserIn) , Stamm, Thomas (VerfasserIn) , Stopkova, Pavla (VerfasserIn) , Maj, Mario (VerfasserIn) , Turecki, Gustavo (VerfasserIn) , Vieta, Eduard (VerfasserIn) , Veeh, Julia (VerfasserIn) , Witt, Stephanie (VerfasserIn) , Wright, Adam (VerfasserIn) , Zandi, Peter P. (VerfasserIn) , Mitchell, Philip B. (VerfasserIn) , Bauer, Michael (VerfasserIn) , Alda, Martin (VerfasserIn) , Rietschel, Marcella (VerfasserIn) , McMahon, Francis J. (VerfasserIn) , Schulze, Thomas G. (VerfasserIn) , Clark, Scott R. (VerfasserIn) , Baune, Bernhard T. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 11 July 2023
In: Molecular psychiatry
Year: 2023, Jahrgang: 28, Heft: 12, Pages: 5251-5261
ISSN:1476-5578
DOI:10.1038/s41380-023-02149-1
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41380-023-02149-1
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41380-023-02149-1
Volltext
Verfasserangaben:Azmeraw T. Amare, Anbupalam Thalamuthu, Klaus Oliver Schubert, Janice M. Fullerton, Muktar Ahmed, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Liping Hou, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Roland Hasler, Hélène Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Maria Del Zompo, J. Raymond DePaulo, Bruno Étain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Andreas J. Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef Dietrich, Christian Figge, Markus Jäger, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauß, Andrea Schmitt, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Jörg Zimmermann, Till F. M. Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cüneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S. Haussleiter, Martin Lambert, Anja C. Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Novák, Claire O’Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Scott R. Clark & Bernhard T. Baune

MARC

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245 1 0 |a Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder  |b article  |c Azmeraw T. Amare, Anbupalam Thalamuthu, Klaus Oliver Schubert, Janice M. Fullerton, Muktar Ahmed, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Liping Hou, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Roland Hasler, Hélène Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Maria Del Zompo, J. Raymond DePaulo, Bruno Étain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Andreas J. Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef Dietrich, Christian Figge, Markus Jäger, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauß, Andrea Schmitt, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Jörg Zimmermann, Till F. M. Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cüneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S. Haussleiter, Martin Lambert, Anja C. Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Novák, Claire O’Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Scott R. Clark & Bernhard T. Baune 
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520 |a Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium’s possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N = 2367) and replicated in the combined PsyCourse (N = 89) and BipoLife (N = 102) studies. The associations of Li+PGS and lithium treatment response — defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P < 0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P = 9.8 × 10−12, R2 = 1.9%) and continuous (P = 6.4 × 10−9, R2 = 2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P = 3.9 × 10−4, R2 = 0.9%), but not for the continuous outcome (P = 0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment. 
650 4 |a Bipolar disorder 
650 4 |a Genetics 
650 4 |a Predictive markers 
700 1 |a Thalamuthu, Anbupalam  |e VerfasserIn  |4 aut 
700 1 |a Schubert, Klaus Oliver  |e VerfasserIn  |4 aut 
700 1 |a Figge, Christian  |e VerfasserIn  |4 aut 
700 1 |a Fullerton, Janice M.  |e VerfasserIn  |4 aut 
700 1 |a Ahmed, Muktar  |e VerfasserIn  |4 aut 
700 1 |a Hartmann, Simon  |e VerfasserIn  |4 aut 
700 1 |a Papiol, Sergi  |e VerfasserIn  |4 aut 
700 1 |a Heilbronner, Urs  |e VerfasserIn  |4 aut 
700 1 |a Degenhardt, Franziska  |e VerfasserIn  |4 aut 
700 1 |a Tekola-Ayele, Fasil  |e VerfasserIn  |4 aut 
700 1 |a Hou, Liping  |e VerfasserIn  |4 aut 
700 1 |a Hsu, Yi-Hsiang  |e VerfasserIn  |4 aut 
700 1 |a Shekhtman, Tatyana  |e VerfasserIn  |4 aut 
700 1 |a Adli, Mazda  |e VerfasserIn  |4 aut 
700 1 |a Akula, Nirmala  |e VerfasserIn  |4 aut 
700 1 |a Akiyama, Kazufumi  |e VerfasserIn  |4 aut 
700 1 |a Ardau, Raffaella  |e VerfasserIn  |4 aut 
700 1 |a Arias, Bárbara  |e VerfasserIn  |4 aut 
700 1 |a Aubry, Jean-Michel  |e VerfasserIn  |4 aut 
700 1 |a Hasler, Roland  |e VerfasserIn  |4 aut 
700 1 |a Richard-Lepouriel, Hélène  |e VerfasserIn  |4 aut 
700 1 |a Perroud, Nader  |e VerfasserIn  |4 aut 
700 1 |a Backlund, Lena  |e VerfasserIn  |4 aut 
700 1 |a Bhattacharjee, Abesh Kumar  |e VerfasserIn  |4 aut 
700 1 |a Bellivier, Frank  |e VerfasserIn  |4 aut 
700 1 |a Benabarre, Antonio  |e VerfasserIn  |4 aut 
700 1 |a Bengesser, Susanne  |e VerfasserIn  |4 aut 
700 1 |a Biernacka, Joanna M.  |e VerfasserIn  |4 aut 
700 1 |a Birner, Armin  |e VerfasserIn  |4 aut 
700 1 |a Marie-Claire, Cynthia  |e VerfasserIn  |4 aut 
700 1 |a Cervantes, Pablo  |e VerfasserIn  |4 aut 
700 1 |a Chen, Hsi-Chung  |e VerfasserIn  |4 aut 
700 1 |a Chillotti, Caterina  |e VerfasserIn  |4 aut 
700 1 |a Cichon, Sven  |e VerfasserIn  |4 aut 
700 1 |a Cruceanu, Cristiana  |e VerfasserIn  |4 aut 
700 1 |a Czerski, Piotr M.  |e VerfasserIn  |4 aut 
700 1 |a Dalkner, Nina  |e VerfasserIn  |4 aut 
700 1 |a Del Zompo, Maria  |e VerfasserIn  |4 aut 
700 1 |a DePaulo, J. Raymond  |e VerfasserIn  |4 aut 
700 1 |a Étain, Bruno  |e VerfasserIn  |4 aut 
700 1 |a Jamain, Stephane  |e VerfasserIn  |4 aut 
700 1 |a Falkai, Peter  |e VerfasserIn  |4 aut 
700 1 |a Forstner, Andreas J.  |e VerfasserIn  |4 aut 
700 1 |a Frisen, Louise  |e VerfasserIn  |4 aut 
700 1 |a Frye, Mark A.  |e VerfasserIn  |4 aut 
700 1 |a Gard, Sébastien  |e VerfasserIn  |4 aut 
700 1 |a Garnham, Julie S.  |e VerfasserIn  |4 aut 
700 1 |a Goes, Fernando S.  |e VerfasserIn  |4 aut 
700 1 |a Grigoroiu-Serbanescu, Maria  |e VerfasserIn  |4 aut 
700 1 |a Fallgatter, Andreas J.  |e VerfasserIn  |4 aut 
700 1 |a Stegmaier, Sophia  |e VerfasserIn  |4 aut 
700 1 |a Ethofer, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Biere, Silvia  |e VerfasserIn  |4 aut 
700 1 |a Petrova, Kristiyana  |e VerfasserIn  |4 aut 
700 1 |a Schuster, Ceylan  |e VerfasserIn  |4 aut 
700 1 |a Adorjan, Kristina  |e VerfasserIn  |4 aut 
700 1 |a Budde, Monika  |e VerfasserIn  |4 aut 
700 1 |a Heilbronner, Maria  |e VerfasserIn  |4 aut 
700 1 |a Kalman, Janos L.  |e VerfasserIn  |4 aut 
700 1 |a Kohshour, Mojtaba Oraki  |e VerfasserIn  |4 aut 
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700 1 |a Senner, Fanny  |e VerfasserIn  |4 aut 
700 1 |a Vogl, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Anghelescu, Ion-George  |e VerfasserIn  |4 aut 
700 1 |a Arolt, Volker  |e VerfasserIn  |4 aut 
700 1 |a Dannlowski, Udo  |e VerfasserIn  |4 aut 
700 1 |a Dietrich, Detlef  |e VerfasserIn  |4 aut 
700 1 |a Jäger, Markus  |e VerfasserIn  |4 aut 
700 1 |a Lang, Fabian U.  |e VerfasserIn  |4 aut 
700 1 |a Juckel, Georg  |e VerfasserIn  |4 aut 
700 1 |a Konrad, Carsten  |e VerfasserIn  |4 aut 
700 1 |a Reimer, Jens  |e VerfasserIn  |4 aut 
700 1 |a Schmauß, Max  |e VerfasserIn  |4 aut 
700 1 |a Schmitt, Andrea  |e VerfasserIn  |4 aut 
700 1 |a Spitzer, Carsten  |e VerfasserIn  |4 aut 
700 1 |a von Hagen, Martin  |e VerfasserIn  |4 aut 
700 1 |a Wiltfang, Jens  |e VerfasserIn  |4 aut 
700 1 |a Zimmermann, Jörg  |e VerfasserIn  |4 aut 
700 1 |a Andlauer, Till F. M.  |e VerfasserIn  |4 aut 
700 1 |a Fischer, Andre  |e VerfasserIn  |4 aut 
700 1 |a Bermpohl, Felix  |e VerfasserIn  |4 aut 
700 1 |a Ritter, Philipp  |e VerfasserIn  |4 aut 
700 1 |a Matura, Silke  |e VerfasserIn  |4 aut 
700 1 |a Gryaznova, Anna  |e VerfasserIn  |4 aut 
700 1 |a Falkenberg, Irina  |e VerfasserIn  |4 aut 
700 1 |a Yildiz, Cüneyt  |e VerfasserIn  |4 aut 
700 1 |a Kircher, Tilo  |e VerfasserIn  |4 aut 
700 1 |a Schmidt, Julia  |e VerfasserIn  |4 aut 
700 1 |a Koch, Marius  |e VerfasserIn  |4 aut 
700 1 |a Gade, Kathrin  |e VerfasserIn  |4 aut 
700 1 |a Trost, Sarah  |e VerfasserIn  |4 aut 
700 1 |a Haussleiter, Ida S.  |e VerfasserIn  |4 aut 
700 1 |a Lambert, Martin  |e VerfasserIn  |4 aut 
700 1 |a Rohenkohl, Anja C.  |e VerfasserIn  |4 aut 
700 1 |a Kraft, Vivien  |e VerfasserIn  |4 aut 
700 1 |a Grof, Paul  |e VerfasserIn  |4 aut 
700 1 |a Hashimoto, Ryota  |e VerfasserIn  |4 aut 
700 1 |a Hauser, Joanna  |e VerfasserIn  |4 aut 
700 1 |a Herms, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Hoffmann, Per  |e VerfasserIn  |4 aut 
700 1 |a Jiménez, Esther  |e VerfasserIn  |4 aut 
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