Association between retinal thickness and disease characteristics in adult epilepsy: a cross-sectional OCT evaluation
Objective Thinning of the peripapillary retinal nerve fiber layer (p-RNFL), as measured by optical coherence tomography (OCT), was recently introduced as a promising marker for cerebral neuronal loss in people with epilepsy (PwE). However, its clinical implication remains to be elucidated. We thus a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
Februar 2024
|
| In: |
Epilepsia open
Year: 2024, Volume: 9, Issue: 1, Pages: 236-249 |
| ISSN: | 2470-9239 |
| DOI: | 10.1002/epi4.12859 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/epi4.12859 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/epi4.12859 
|
| Author Notes: | Luisa Delazer, Han Bao, Michael Lauseker, Livia Stauner, Georg Nübling, Julian Conrad, Soheyl Noachtar, Joachim Havla, Elisabeth Kaufmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1880835304 | ||
| 003 | DE-627 | ||
| 005 | 20240307020511.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240215s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/epi4.12859 |2 doi | |
| 035 | |a (DE-627)1880835304 | ||
| 035 | |a (DE-599)KXP1880835304 | ||
| 035 | |a (OCoLC)1425200267 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Delazer, Luisa |e VerfasserIn |0 (DE-588)1320670008 |0 (DE-627)1881096106 |4 aut | |
| 245 | 1 | 0 | |a Association between retinal thickness and disease characteristics in adult epilepsy |b a cross-sectional OCT evaluation |c Luisa Delazer, Han Bao, Michael Lauseker, Livia Stauner, Georg Nübling, Julian Conrad, Soheyl Noachtar, Joachim Havla, Elisabeth Kaufmann |
| 264 | 1 | |c Februar 2024 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht am 3. November 2023 | ||
| 500 | |a Gesehen am 15.02.2024 | ||
| 520 | |a Objective Thinning of the peripapillary retinal nerve fiber layer (p-RNFL), as measured by optical coherence tomography (OCT), was recently introduced as a promising marker for cerebral neuronal loss in people with epilepsy (PwE). However, its clinical implication remains to be elucidated. We thus aimed to (1) systematically characterize the extent of the retinal neuroaxonal loss in a broad spectrum of unselected PwE and (2) to evaluate the main clinical determinants. Methods In this prospective study, a spectral-domain OCT evaluation was performed on 98 well-characterized PwE and 85 healthy controls (HCs) (18-55 years of age). All inner retinal layers and the total macula volume were assessed. Group comparisons and linear regression analyses with stepwise backward selection were performed to identify relevant clinical and demographic modulators of the retinal neuroaxonal integrity. Results PwE (age: 33.7 ± 10.6 years; 58.2% female) revealed a significant neuroaxonal loss across all assessed retinal layers (global pRNFL, P = 0.001, Δ = 4.24 μm; macular RNFL, P < 0.001, Δ = 0.05 mm3; ganglion cell inner plexiform layer, P < 0.001, Δ = 0.11 mm3; inner nuclear layer, INL, P = 0.03, Δ = 0.02 mm3) as well as significantly reduced total macula volumes (TMV, P < 0.001, Δ = 0.18 mm3) compared to HCs (age: 31.2 ± 9.0 years; 57.6% female). The extent of retinal neuroaxonal loss was associated with the occurrence and frequency of tonic-clonic seizures and the number of antiseizure medications, and was most pronounced in male patients. Significance PwE presented an extensive retinal neuroaxonal loss, affecting not only the peripapillary but also macular structures. The noninvasive and economic measurement via OCT bears the potential to establish as a practical tool to inform patient management, as the extent of the retinal neuroaxonal loss reflects aspects of disease severity and sex-specific vulnerability. Plain Language Summary The retina is an extension of the brain and closely connected to it. Thus, cerebral alterations like atrophy reflect also on the retinal level. This is advantageous, as the retina is easily accessible and measureable with help of the optical coherence tomography. Here we report that adults with epilepsy have a significantly thinner retina than healthy persons. Especially people with many big seizures and a lot of medications have a thinner retina. We propose that measurement of the retina can be useful as a marker of disease severity and to inform patient management. | ||
| 650 | 4 | |a anti-seizure medication | |
| 650 | 4 | |a brain atrophy | |
| 650 | 4 | |a disease burden | |
| 650 | 4 | |a focal to bilateral tonic clonic seizures | |
| 650 | 4 | |a optical coherence tomography | |
| 650 | 4 | |a sexual dimorphism | |
| 700 | 1 | |a Bao, Han |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lauseker, Michael |d 1981- |e VerfasserIn |0 (DE-588)1058710265 |0 (DE-627)79743223X |0 (DE-576)414848438 |4 aut | |
| 700 | 1 | |a Stauner, Livia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nübling, Georg |d 1984- |e VerfasserIn |0 (DE-588)1026451418 |0 (DE-627)726743763 |0 (DE-576)371794129 |4 aut | |
| 700 | 1 | |a Conrad, Julian |d 1984- |e VerfasserIn |0 (DE-588)1045448508 |0 (DE-627)774514965 |0 (DE-576)399216510 |4 aut | |
| 700 | 1 | |a Noachtar, Soheyl |e VerfasserIn |0 (DE-588)1149784946 |0 (DE-627)101009517X |0 (DE-576)496839578 |4 aut | |
| 700 | 1 | |a Havla, Joachim |d 1981- |e VerfasserIn |0 (DE-588)141343583 |0 (DE-627)629423946 |0 (DE-576)324224184 |4 aut | |
| 700 | 1 | |a Kaufmann, Elisabeth |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Epilepsia open |d Hoboken, NJ : Wiley, 2016 |g 9(2024), 1 vom: Feb., Seite 236-249 |h Online-Ressource |w (DE-627)863942067 |w (DE-600)2863427-5 |w (DE-576)475442954 |x 2470-9239 |7 nnas |a Association between retinal thickness and disease characteristics in adult epilepsy a cross-sectional OCT evaluation |
| 773 | 1 | 8 | |g volume:9 |g year:2024 |g number:1 |g month:02 |g pages:236-249 |g extent:14 |a Association between retinal thickness and disease characteristics in adult epilepsy a cross-sectional OCT evaluation |
| 856 | 4 | 0 | |u https://doi.org/10.1002/epi4.12859 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/epi4.12859 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240215 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1045448508 |a Conrad, Julian |m 1045448508:Conrad, Julian |d 60000 |d 62700 |e 60000PC1045448508 |e 62700PC1045448508 |k 0/60000/ |k 1/60000/62700/ |p 6 | ||
| 999 | |a KXP-PPN1880835304 |e 4484631547 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"863942067","disp":"Association between retinal thickness and disease characteristics in adult epilepsy a cross-sectional OCT evaluationEpilepsia open","id":{"eki":["863942067"],"issn":["2470-9239"],"zdb":["2863427-5"]},"origin":[{"publisher":"Wiley","dateIssuedDisp":"[2016]-","publisherPlace":"Hoboken, NJ"}],"part":{"year":"2024","issue":"1","pages":"236-249","volume":"9","text":"9(2024), 1 vom: Feb., Seite 236-249","extent":"14"},"corporate":[{"role":"isb","display":"International League against Epilepsy"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 29.05.2020"],"pubHistory":["21. Jul 2016-"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Epilepsia open","title":"Epilepsia open","subtitle":"the open access journal of the International League Against Epilepsy"}]}],"note":["Online veröffentlicht am 3. November 2023","Gesehen am 15.02.2024"],"name":{"displayForm":["Luisa Delazer, Han Bao, Michael Lauseker, Livia Stauner, Georg Nübling, Julian Conrad, Soheyl Noachtar, Joachim Havla, Elisabeth Kaufmann"]},"recId":"1880835304","id":{"doi":["10.1002/epi4.12859"],"eki":["1880835304"]},"origin":[{"dateIssuedDisp":"Februar 2024","dateIssuedKey":"2024"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"14 S."}],"language":["eng"],"person":[{"family":"Delazer","role":"aut","given":"Luisa","display":"Delazer, Luisa"},{"family":"Bao","given":"Han","role":"aut","display":"Bao, Han"},{"family":"Lauseker","role":"aut","given":"Michael","display":"Lauseker, Michael"},{"family":"Stauner","role":"aut","given":"Livia","display":"Stauner, Livia"},{"role":"aut","given":"Georg","family":"Nübling","display":"Nübling, Georg"},{"family":"Conrad","role":"aut","given":"Julian","display":"Conrad, Julian"},{"role":"aut","given":"Soheyl","family":"Noachtar","display":"Noachtar, Soheyl"},{"display":"Havla, Joachim","role":"aut","given":"Joachim","family":"Havla"},{"family":"Kaufmann","role":"aut","given":"Elisabeth","display":"Kaufmann, Elisabeth"}],"title":[{"subtitle":"a cross-sectional OCT evaluation","title":"Association between retinal thickness and disease characteristics in adult epilepsy","title_sort":"Association between retinal thickness and disease characteristics in adult epilepsy"}]} | ||
| SRT | |a DELAZERLUIASSOCIATIO2024 | ||