Cover Image

Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer

Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associatio...

Full description

Saved in:
Bibliographic Details
Main Authors: Wichert, Katharina (Author) , Hoppe, Reiner (Author) , Ickstadt, Katja (Author) , Behrens, Thomas (Author) , Winter, Stefan (Author) , Herold, Robert (Author) , Terschüren, Claudia (Author) , Lo, Wing-Yee (Author) , Guénel, Pascal (Author) , Truong, Thérèse (Author) , Bolla, Manjeet K. (Author) , Wang, Qin (Author) , Dennis, Joe (Author) , Michailidou, Kyriaki (Author) , Lush, Michael (Author) , Andrulis, Irene L. (Author) , Brenner, Hermann (Author) , Chang-Claude, Jenny (Author) , Cox, Angela (Author) , Cross, Simon S. (Author) , Czene, Kamila (Author) , Eriksson, Mikael (Author) , Figueroa, Jonine D. (Author) , García-Closas, Montserrat (Author) , Goldberg, Mark S. (Author) , Hamann, Ute (Author) , He, Wei (Author) , Holleczek, Bernd (Author) , Hopper, John L. (Author) , Jakubowska, Anna (Author) , Ko, Yon-Dschun (Author) , Lubiński, Jan (Author) , Mulligan, Anna Marie (Author) , Obi, Nadia (Author) , Rhenius, Valerie (Author) , Shah, Mitul (Author) , Shu, Xiao-Ou (Author) , Simard, Jacques (Author) , Southey, Melissa C. (Author) , Zheng, Wei (Author) , Dunning, Alison M. (Author) , Pharoah, Paul D. P. (Author) , Hall, Per (Author) , Easton, Douglas F. (Author) , Brüning, Thomas (Author) , Brauch, Hiltrud (Author) , Harth, Volker (Author) , Rabstein, Sylvia (Author)
Format: Article (Journal)
Language:English
Published: 03 October 2023
In: European journal of epidemiology
Year: 2023, Volume: 38, Issue: 10, Pages: 1053-1068
ISSN:1573-7284
DOI:10.1007/s10654-023-01048-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10654-023-01048-7
Get full text
Author Notes:Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Robert Herold, Claudia Terschüren, Wing-Yee Lo, Pascal Guénel, Thérèse Truong, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Irene L. Andrulis, Hermann Brenner, Jenny Chang-Claude, Angela Cox, Simon S. Cross, Kamila Czene, Mikael Eriksson, Jonine D. Figueroa, Montserrat García-Closas, Mark S. Goldberg, Ute Hamann, Wei He, Bernd Holleczek, John L. Hopper, Anna Jakubowska, Yon-Dschun Ko, Jan Lubiński, Anna Marie Mulligan, Nadia Obi, Valerie Rhenius, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C. Southey, Wei Zheng, Alison M. Dunning, Paul D.P. Pharoah, Per Hall, Douglas F. Easton, Thomas Brüning, Hiltrud Brauch, Volker Harth, Sylvia Rabstein

MARC

LEADER 00000caa a2200000 c 4500
001 1880997339
003 DE-627
005 20250827152713.0
007 cr uuu---uuuuu
008 240216s2023 xx |||||o 00| ||eng c
024 7 |a 10.1007/s10654-023-01048-7  |2 doi 
035 |a (DE-627)1880997339 
035 |a (DE-599)KXP1880997339 
035 |a (OCoLC)1425200689 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Wichert, Katharina  |d 1991-  |e VerfasserIn  |0 (DE-588)1173741933  |0 (DE-627)1043589910  |0 (DE-576)515648108  |4 aut 
245 1 0 |a Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer  |c Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Robert Herold, Claudia Terschüren, Wing-Yee Lo, Pascal Guénel, Thérèse Truong, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Irene L. Andrulis, Hermann Brenner, Jenny Chang-Claude, Angela Cox, Simon S. Cross, Kamila Czene, Mikael Eriksson, Jonine D. Figueroa, Montserrat García-Closas, Mark S. Goldberg, Ute Hamann, Wei He, Bernd Holleczek, John L. Hopper, Anna Jakubowska, Yon-Dschun Ko, Jan Lubiński, Anna Marie Mulligan, Nadia Obi, Valerie Rhenius, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C. Southey, Wei Zheng, Alison M. Dunning, Paul D.P. Pharoah, Per Hall, Douglas F. Easton, Thomas Brüning, Hiltrud Brauch, Volker Harth, Sylvia Rabstein 
264 1 |c 03 October 2023 
300 |a 16 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 16.02.2024 
520 |a Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls). Genotype data of 97 candidate single nucleotide polymorphisms (SNPs) at 18 defined gene regions were investigated for breast-cancer risk effects. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CI) by logistic regression for the main-effect analysis as well as stratified analyses by estrogen- and progesterone-receptor (ER, PR) status. SNP-SNP interactions were analyzed via a two-step procedure based on logic regression. The Bayesian false-discovery probability (BFDP) was used for all analyses to account for multiple testing. Noteworthy associations (BFDP < 0.8) included 10 linked SNPs in tryptophan hydroxylase 2 (TPH2) (e.g. rs1386492: OR = 1.07, 95% CI 1.02-1.12), and a SNP in the mitogen-activated protein kinase 8 (MAPK8) (rs10857561: OR = 1.11, 95% CI 1.04-1.18). The SNP-SNP interaction analysis revealed noteworthy interaction terms with TPH2- and MAPK-related SNPs (e.g. rs1386483R ∧ rs1473473D ∧ rs3729931D: OR = 1.20, 95% CI 1.09-1.32). In line with the light-at-night hypothesis that links shift work with elevated breast-cancer risks our results point to SNPs in TPH2 and MAPK-genes that may impact the intricate network of circadian regulation. 
650 4 |a Circadian rhythm 
650 4 |a MAPK8 
650 4 |a Serotonin biosynthesis 
650 4 |a Shift work 
650 4 |a TPH2 
700 1 |a Hoppe, Reiner  |e VerfasserIn  |4 aut 
700 1 |a Ickstadt, Katja  |e VerfasserIn  |4 aut 
700 1 |a Behrens, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Winter, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Herold, Robert  |e VerfasserIn  |4 aut 
700 1 |a Terschüren, Claudia  |e VerfasserIn  |4 aut 
700 1 |a Lo, Wing-Yee  |e VerfasserIn  |4 aut 
700 1 |a Guénel, Pascal  |e VerfasserIn  |4 aut 
700 1 |a Truong, Thérèse  |e VerfasserIn  |4 aut 
700 1 |a Bolla, Manjeet K.  |e VerfasserIn  |4 aut 
700 1 |a Wang, Qin  |e VerfasserIn  |4 aut 
700 1 |a Dennis, Joe  |e VerfasserIn  |4 aut 
700 1 |a Michailidou, Kyriaki  |e VerfasserIn  |4 aut 
700 1 |a Lush, Michael  |e VerfasserIn  |4 aut 
700 1 |a Andrulis, Irene L.  |e VerfasserIn  |4 aut 
700 1 |a Brenner, Hermann  |e VerfasserIn  |0 (DE-588)1020516445  |0 (DE-627)691247005  |0 (DE-576)360642136  |4 aut 
700 1 |a Chang-Claude, Jenny  |e VerfasserIn  |0 (DE-588)1049304993  |0 (DE-627)781626188  |0 (DE-576)168344475  |4 aut 
700 1 |a Cox, Angela  |e VerfasserIn  |4 aut 
700 1 |a Cross, Simon S.  |e VerfasserIn  |4 aut 
700 1 |a Czene, Kamila  |e VerfasserIn  |4 aut 
700 1 |a Eriksson, Mikael  |e VerfasserIn  |4 aut 
700 1 |a Figueroa, Jonine D.  |e VerfasserIn  |4 aut 
700 1 |a García-Closas, Montserrat  |e VerfasserIn  |4 aut 
700 1 |a Goldberg, Mark S.  |e VerfasserIn  |4 aut 
700 1 |a Hamann, Ute  |e VerfasserIn  |0 (DE-588)1074024230  |0 (DE-627)830169970  |0 (DE-576)161285090  |4 aut 
700 1 |a He, Wei  |e VerfasserIn  |4 aut 
700 1 |a Holleczek, Bernd  |d 1973-  |e VerfasserIn  |0 (DE-588)1053591020  |0 (DE-627)790337649  |0 (DE-576)409545155  |4 aut 
700 1 |a Hopper, John L.  |e VerfasserIn  |4 aut 
700 1 |a Jakubowska, Anna  |e VerfasserIn  |4 aut 
700 1 |a Ko, Yon-Dschun  |e VerfasserIn  |4 aut 
700 1 |a Lubiński, Jan  |e VerfasserIn  |4 aut 
700 1 |a Mulligan, Anna Marie  |e VerfasserIn  |4 aut 
700 1 |a Obi, Nadia  |e VerfasserIn  |4 aut 
700 1 |a Rhenius, Valerie  |e VerfasserIn  |4 aut 
700 1 |a Shah, Mitul  |e VerfasserIn  |4 aut 
700 1 |a Shu, Xiao-Ou  |e VerfasserIn  |4 aut 
700 1 |a Simard, Jacques  |e VerfasserIn  |4 aut 
700 1 |a Southey, Melissa C.  |e VerfasserIn  |4 aut 
700 1 |a Zheng, Wei  |e VerfasserIn  |4 aut 
700 1 |a Dunning, Alison M.  |e VerfasserIn  |4 aut 
700 1 |a Pharoah, Paul D. P.  |e VerfasserIn  |4 aut 
700 1 |a Hall, Per  |e VerfasserIn  |4 aut 
700 1 |a Easton, Douglas F.  |e VerfasserIn  |4 aut 
700 1 |a Brüning, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Brauch, Hiltrud  |e VerfasserIn  |4 aut 
700 1 |a Harth, Volker  |e VerfasserIn  |4 aut 
700 1 |a Rabstein, Sylvia  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t European journal of epidemiology  |d [Cham] : Springer Nature Switzerland AG, 1985  |g 38(2023), 10, Seite 1053-1068  |h Online-Ressource  |w (DE-627)320441636  |w (DE-600)2004992-4  |w (DE-576)121465535  |x 1573-7284  |7 nnas  |a Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer 
773 1 8 |g volume:38  |g year:2023  |g number:10  |g pages:1053-1068  |g extent:16  |a Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer 
856 4 0 |u https://doi.org/10.1007/s10654-023-01048-7  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20240216 
993 |a Article 
994 |a 2023 
998 |g 1053591020  |a Holleczek, Bernd  |m 1053591020:Holleczek, Bernd  |d 50000  |e 50000PH1053591020  |k 0/50000/  |p 28 
998 |g 1074024230  |a Hamann, Ute  |m 1074024230:Hamann, Ute  |d 50000  |e 50000PH1074024230  |k 0/50000/  |p 26 
998 |g 1049304993  |a Chang-Claude, Jenny  |m 1049304993:Chang-Claude, Jenny  |d 50000  |e 50000PC1049304993  |k 0/50000/  |p 18 
998 |g 1020516445  |a Brenner, Hermann  |m 1020516445:Brenner, Hermann  |d 850000  |d 851600  |d 50000  |e 850000PB1020516445  |e 851600PB1020516445  |e 50000PB1020516445  |k 0/850000/  |k 1/850000/851600/  |k 0/50000/  |p 17 
999 |a KXP-PPN1880997339  |e 4485777057 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 16.02.2024"],"origin":[{"dateIssuedDisp":"03 October 2023","dateIssuedKey":"2023"}],"relHost":[{"disp":"Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancerEuropean journal of epidemiology","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"text":"38(2023), 10, Seite 1053-1068","pages":"1053-1068","issue":"10","volume":"38","year":"2023","extent":"16"},"title":[{"title_sort":"European journal of epidemiology","title":"European journal of epidemiology"}],"recId":"320441636","id":{"zdb":["2004992-4"],"issn":["1573-7284"],"eki":["320441636"]},"pubHistory":["1.1985 -"],"origin":[{"dateIssuedKey":"1985","publisherPlace":"[Cham] ; Dordrecht [u.a.] ; Dordrecht [u.a.] ; Dordrecht [u.a.]","dateIssuedDisp":"1985-","publisher":"Springer Nature Switzerland AG ; Springer Science + Business Media B.V. ; Springer Science + Business Media B.V. ; Kluwer Acad. Publ."}],"note":["Gesehen am 26.08.2020","Gesehen am 16.03.09"],"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"family":"Wichert","given":"Katharina","role":"aut","display":"Wichert, Katharina"},{"family":"Hoppe","given":"Reiner","role":"aut","display":"Hoppe, Reiner"},{"family":"Ickstadt","given":"Katja","display":"Ickstadt, Katja","role":"aut"},{"family":"Behrens","given":"Thomas","display":"Behrens, Thomas","role":"aut"},{"given":"Stefan","family":"Winter","role":"aut","display":"Winter, Stefan"},{"role":"aut","display":"Herold, Robert","given":"Robert","family":"Herold"},{"given":"Claudia","family":"Terschüren","display":"Terschüren, Claudia","role":"aut"},{"display":"Lo, Wing-Yee","role":"aut","family":"Lo","given":"Wing-Yee"},{"given":"Pascal","family":"Guénel","display":"Guénel, Pascal","role":"aut"},{"family":"Truong","given":"Thérèse","role":"aut","display":"Truong, Thérèse"},{"role":"aut","display":"Bolla, Manjeet K.","family":"Bolla","given":"Manjeet K."},{"display":"Wang, Qin","role":"aut","given":"Qin","family":"Wang"},{"display":"Dennis, Joe","role":"aut","family":"Dennis","given":"Joe"},{"given":"Kyriaki","family":"Michailidou","role":"aut","display":"Michailidou, Kyriaki"},{"role":"aut","display":"Lush, Michael","given":"Michael","family":"Lush"},{"display":"Andrulis, Irene L.","role":"aut","family":"Andrulis","given":"Irene L."},{"display":"Brenner, Hermann","role":"aut","given":"Hermann","family":"Brenner"},{"display":"Chang-Claude, Jenny","role":"aut","given":"Jenny","family":"Chang-Claude"},{"given":"Angela","family":"Cox","display":"Cox, Angela","role":"aut"},{"family":"Cross","given":"Simon S.","role":"aut","display":"Cross, Simon S."},{"family":"Czene","given":"Kamila","role":"aut","display":"Czene, Kamila"},{"given":"Mikael","family":"Eriksson","display":"Eriksson, Mikael","role":"aut"},{"family":"Figueroa","given":"Jonine D.","role":"aut","display":"Figueroa, Jonine D."},{"given":"Montserrat","family":"García-Closas","display":"García-Closas, Montserrat","role":"aut"},{"given":"Mark S.","family":"Goldberg","role":"aut","display":"Goldberg, Mark S."},{"display":"Hamann, Ute","role":"aut","given":"Ute","family":"Hamann"},{"family":"He","given":"Wei","display":"He, Wei","role":"aut"},{"role":"aut","display":"Holleczek, Bernd","given":"Bernd","family":"Holleczek"},{"given":"John L.","family":"Hopper","display":"Hopper, John L.","role":"aut"},{"display":"Jakubowska, Anna","role":"aut","family":"Jakubowska","given":"Anna"},{"given":"Yon-Dschun","family":"Ko","display":"Ko, Yon-Dschun","role":"aut"},{"display":"Lubiński, Jan","role":"aut","family":"Lubiński","given":"Jan"},{"given":"Anna Marie","family":"Mulligan","display":"Mulligan, Anna Marie","role":"aut"},{"role":"aut","display":"Obi, Nadia","given":"Nadia","family":"Obi"},{"display":"Rhenius, Valerie","role":"aut","family":"Rhenius","given":"Valerie"},{"display":"Shah, Mitul","role":"aut","family":"Shah","given":"Mitul"},{"family":"Shu","given":"Xiao-Ou","role":"aut","display":"Shu, Xiao-Ou"},{"role":"aut","display":"Simard, Jacques","given":"Jacques","family":"Simard"},{"role":"aut","display":"Southey, Melissa C.","family":"Southey","given":"Melissa C."},{"display":"Zheng, Wei","role":"aut","family":"Zheng","given":"Wei"},{"given":"Alison M.","family":"Dunning","display":"Dunning, Alison M.","role":"aut"},{"role":"aut","display":"Pharoah, Paul D. P.","family":"Pharoah","given":"Paul D. P."},{"display":"Hall, Per","role":"aut","given":"Per","family":"Hall"},{"family":"Easton","given":"Douglas F.","display":"Easton, Douglas F.","role":"aut"},{"display":"Brüning, Thomas","role":"aut","family":"Brüning","given":"Thomas"},{"given":"Hiltrud","family":"Brauch","display":"Brauch, Hiltrud","role":"aut"},{"family":"Harth","given":"Volker","display":"Harth, Volker","role":"aut"},{"given":"Sylvia","family":"Rabstein","display":"Rabstein, Sylvia","role":"aut"}],"title":[{"title":"Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer","title_sort":"Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer"}],"physDesc":[{"extent":"16 S."}],"recId":"1880997339","language":["eng"],"name":{"displayForm":["Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Robert Herold, Claudia Terschüren, Wing-Yee Lo, Pascal Guénel, Thérèse Truong, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Irene L. Andrulis, Hermann Brenner, Jenny Chang-Claude, Angela Cox, Simon S. Cross, Kamila Czene, Mikael Eriksson, Jonine D. Figueroa, Montserrat García-Closas, Mark S. Goldberg, Ute Hamann, Wei He, Bernd Holleczek, John L. Hopper, Anna Jakubowska, Yon-Dschun Ko, Jan Lubiński, Anna Marie Mulligan, Nadia Obi, Valerie Rhenius, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C. Southey, Wei Zheng, Alison M. Dunning, Paul D.P. Pharoah, Per Hall, Douglas F. Easton, Thomas Brüning, Hiltrud Brauch, Volker Harth, Sylvia Rabstein"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1880997339"],"doi":["10.1007/s10654-023-01048-7"]}} 
SRT |a WICHERTKATPOLYMORPHI0320 

Similar Items