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Prediction of high bell stages of necrotizing enterocolitis using a mathematic formula for risk determination

Necrotizing enterocolitis (NEC) continues to cause high morbidity and mortality. Identifying early predictors for severe NEC is essential to improve therapy and optimize timing for surgical intervention. We present a retrospective study of patients with NEC, treated between 2010 and 2020, trying to...

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Bibliographische Detailangaben
Hauptverfasser: Diez, Sonja (VerfasserIn) , Bell, Lea Emilia (VerfasserIn) , Moosmann, Julia (VerfasserIn) , Weiß, Christel (VerfasserIn) , Müller, Hanna (VerfasserIn) , Besendörfer, Manuel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 24 April 2022
In: Children
Year: 2022, Jahrgang: 9, Heft: 5, Pages: 1-12
ISSN:2227-9067
DOI:10.3390/children9050604
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/children9050604
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2227-9067/9/5/604
Volltext
Verfasserangaben:Sonja Diez, Lea Emilia Bell, Julia Moosmann, Christel Weiss, Hanna Müller, and Manuel Besendörfer
Beschreibung
Zusammenfassung:Necrotizing enterocolitis (NEC) continues to cause high morbidity and mortality. Identifying early predictors for severe NEC is essential to improve therapy and optimize timing for surgical intervention. We present a retrospective study of patients with NEC, treated between 2010 and 2020, trying to identify factors influencing the severity of NEC. Within the study period, 88 affected infants with NEC or NEC-like symptoms are analyzed. A multiple logistic regression analysis reveals the following three independent predictors for NEC in Bell stage III: red blood cell transfusion (p = 0.027 with odds ratio (OR) = 3.298), sonographic findings (p = 0.037; OR = 6.496 for patients with positive vs. patients without pathological findings) and cardiac anatomy (p = 0.015; OR = 1.922 for patients with patent ductus arteriosus (PDA) vs. patients with congenital heart disease (CHD); OR = 5.478/OR = 2.850 for patients with CHD/PDA vs. patients without cardiac disease). Results are summarized in a clinical score for daily application in clinical routine. The score is easy to apply and combines clinically established parameters, helping to determine the timing of surgical intervention.
Beschreibung:Gesehen am 19.02.2024
Beschreibung:Online Resource
ISSN:2227-9067
DOI:10.3390/children9050604

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