GLOS and HARM in patients with transient neurovascular symptoms with and without ischemic infarction
Background and purpose - Gadolinium leakage in ocular structures (GLOS) on fluid attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke and other neurological disorders. - Methods - In patients with transient neurovascular symptoms who underwent repeated MRI...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2022
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| In: |
Journal of neuroradiology
Year: 2022, Jahrgang: 49, Heft: 3, Pages: 244-249 |
| ISSN: | 1773-0406 |
| DOI: | 10.1016/j.neurad.2021.03.007 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neurad.2021.03.007 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0150986121000626 
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| Verfasserangaben: | A. Förster, Ana Ramos, H. Wenz, J Böhme, C. Groden, A. Alonso |
MARC
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| 245 | 1 | 0 | |a GLOS and HARM in patients with transient neurovascular symptoms with and without ischemic infarction |c A. Förster, Ana Ramos, H. Wenz, J Böhme, C. Groden, A. Alonso |
| 264 | 1 | |c May 2022 | |
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| 520 | |a Background and purpose - Gadolinium leakage in ocular structures (GLOS) on fluid attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke and other neurological disorders. - Methods - In patients with transient neurovascular symptoms who underwent repeated MRI with intravenous contrast agent administration, the presence of acute ischemic lesions on diffusion-weighted images (DWI) as well as the frequency and pattern of blood-brain barrier and blood-retina barrier impairment as demonstrated by the hyperintense acute reperfusion marker (HARM) and GLOS respectively on postcontrast FLAIR were evaluated. - Results - Overall 28 patients with transient neurovascular symptoms (median age 70.5 years; 18 (64.3%) male) were included. Follow-up MRI was performed within 35 (IQR 21-47) hours after the initial MRI. On DWI, acute ischemic lesions were observed in 22 (78.6%). On contrast-enhanced FLAIR, GLOS was observed in 12 (42.9%) patients: in 1 (3.6%) only in the anterior chamber, and in 11 (39.3%) in the anterior chamber and vitreous body. HARM was observed in 3 (10.7%) patients. In one patient without ischemic lesion on DWI or HARM on FLAIR, GLOS was observed in the anterior chamber and vitreous body. Presence of GLOS was associated with higher age (p=0.04) and detection of HARM (p=0.03). - Conclusions - In patients with transient neurovascular symptoms, GLOS is a frequent finding and associated with HARM on contrast-enhanced FLAIR. As GLOS was observed in one patient without an ischemic lesion or HARM, it might be useful as an additional imaging marker. | ||
| 650 | 4 | |a Contrast-enhanced FLAIR | |
| 650 | 4 | |a Gadolinium leakage | |
| 650 | 4 | |a GLOS | |
| 650 | 4 | |a Ocular | |
| 650 | 4 | |a Transient ischemic attack | |
| 650 | 4 | |a Transient neurovascular symptoms | |
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| 700 | 1 | |a Alonso, Angelika |d 1977- |e VerfasserIn |0 (DE-588)1025166795 |0 (DE-627)721355315 |0 (DE-576)370025865 |4 aut | |
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