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Outcome assessment of intraoperative radiotherapy for brain metastases: results of a prospective observational study with comparative matched-pair analysis

Intraoperative radiation therapy (IORT) is an emerging alternative to adjuvant stereotactic external beam radiation therapy (EBRT) following resection of brain metastases (BM). Advantages of IORT include an instant prevention of tumor regrowth, optimized dose-sparing of adjacent healthy brain tissue...

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Main Authors: Layer, Julian (Author) , Hamed, Motaz (Author) , Potthoff, Anna-Laura (Author) , Dejonckheere, Cas S. (Author) , Layer, Katharina (Author) , Sarria, Gustavo R. (Author) , Scafa, Davide (Author) , Koch, David (Author) , Köksal, Mümtaz (Author) , Kugel, Fabian (Author) , Grimmer, Molina (Author) , Holz, Jasmin A. (Author) , Zeyen, Thomas (Author) , Friker, Lea L. (Author) , Borger, Valeri (Author) , Schmeel, F. Carsten (Author) , Weller, Johannes (Author) , Hölzel, Michael (Author) , Schäfer, Niklas (Author) , Garbe, Stephan (Author) , Forstbauer, Helmut (Author) , Giordano, Frank Anton (Author) , Herrlinger, Ulrich (Author) , Vatter, Hartmut (Author) , Schneider, Matthias (Author) , Schmeel, L. Christopher (Author)
Format: Article (Journal)
Language:English
Published: August 2023
In: Journal of neuro-oncology
Year: 2023, Volume: 164, Pages: 107-116
ISSN:1573-7373
DOI:10.1007/s11060-023-04380-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-023-04380-w
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s11060-023-04380-w
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Author Notes:Julian P Layer, Motaz Hamed, Anna-Laura Potthoff, Cas S Dejonckheere, Katharina Layer, Gustavo R Sarria, Davide Scafa, David Koch, Mümtaz Köksal, Fabian Kugel, Molina Grimmer, Jasmin A. Holz, Thomas Zeyen, Lea L Friker, Valeri Borger, F Carsten Schmeel, Johannes Weller, Michael Hölzel, Niklas Schäfer, Stephan Garbe, Helmut Forstbauer, Frank A Giordano, Ulrich Herrlinger, Hartmut Vatter, Matthias Schneider & L Christopher Schmeel

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520 |a Intraoperative radiation therapy (IORT) is an emerging alternative to adjuvant stereotactic external beam radiation therapy (EBRT) following resection of brain metastases (BM). Advantages of IORT include an instant prevention of tumor regrowth, optimized dose-sparing of adjacent healthy brain tissue and immediate completion of BM treatment, allowing an earlier admission to subsequent systemic treatments. However, prospective outcome data are limited. We sought to assess long-term outcome of IORT in comparison to EBRT. 
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