HPV-associated head and neck cancer is characterized by distinct profiles of CD8+ T cells and myeloid-derived suppressor cells
Patients with HPV−-localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune p...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 November 2023
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| In: |
Cancer immunology immunotherapy
Year: 2023, Volume: 72, Issue: 12, Pages: 4367-4383 |
| ISSN: | 1432-0851 |
| DOI: | 10.1007/s00262-023-03571-8 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00262-023-03571-8
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| Author Notes: | Benjamin A. Kansy, Tim P. Wehrs, Kirsten Bruderek, Yu Si, Sonja Ludwig, Freya Droege, Pia Hasskamp, Uta Henkel, Nina Dominas, Thomas K. Hoffmann, Peter A. Horn, Martin Schuler, Thomas C. Gauler, Monika Lindemann, Stephan Lang, Agnes Bankfalvi, Sven Brandau |
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| 520 | |a Patients with HPV−-localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune profiles of CD8+ T cells and myeloid-derived suppressor cells (MDSC) in HPV+ versus HPV− disease. | ||
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