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Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the...

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Bibliographische Detailangaben
Hauptverfasser: Wilms, Henrik (VerfasserIn) , Sievers, Jobst (VerfasserIn) , Rickert, Uta (VerfasserIn) , Rostami-Yazdi, Martin (VerfasserIn) , Mrowietz, Ulrich (VerfasserIn) , Lucius, Ralph (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 19 May 2010
In: Journal of neuroinflammation
Year: 2010, Jahrgang: 7, Pages: 1-8
ISSN:1742-2094
DOI:10.1186/1742-2094-7-30
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1742-2094-7-30
Volltext
Verfasserangaben:Henrik Wilms, Jobst Sievers, Uta Rickert, Martin Rostami-Yazdi, Ulrich Mrowietz and Ralph Lucius
Beschreibung
Zusammenfassung:Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the effector cells of neuroinflammation; however, little is known of the effect of DMF on microglia and astrocytes. The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation.
Beschreibung:Gesehen am 26.02.2024
Beschreibung:Online Resource
ISSN:1742-2094
DOI:10.1186/1742-2094-7-30

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