Prognosis of atrial fibrillation in patients with symptomatic peripheral arterial disease: data from the REduction of Atherothrombosis for Continued Health (REACH) registry
Background - Atrial fibrillation (AF) is a significant risk factor for cardiovascular (CV) mortality. This study aims to evaluate the prognostic implication of AF in patients with peripheral arterial disease (PAD). - Methods - The International Reduction of Atherothrombosis for Continued Health (REA...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2010
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| In: |
European journal of vascular and endovascular surgery
Year: 2010, Volume: 40, Issue: 1, Pages: 9-16 |
| ISSN: | 1532-2165 |
| DOI: | 10.1016/j.ejvs.2010.03.003 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejvs.2010.03.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1078588410001528 
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| Author Notes: | T.A. Winkel, S.E. Hoeks, O. Schouten, U. Zeymer, T. Limbourg, I. Baumgartner, D.L. Bhatt, Ph. G. Steg, S. Goto, J. Röther, P.P. Cacoub, H.J.M. Verhagen, J.J. Bax, D. Poldermans |
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| 100 | 1 | |a Winkel, Tamara A. |e VerfasserIn |0 (DE-588)1321748647 |0 (DE-627)1881627462 |4 aut | |
| 245 | 1 | 0 | |a Prognosis of atrial fibrillation in patients with symptomatic peripheral arterial disease |b data from the REduction of Atherothrombosis for Continued Health (REACH) registry |c T.A. Winkel, S.E. Hoeks, O. Schouten, U. Zeymer, T. Limbourg, I. Baumgartner, D.L. Bhatt, Ph. G. Steg, S. Goto, J. Röther, P.P. Cacoub, H.J.M. Verhagen, J.J. Bax, D. Poldermans |
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| 500 | |a Gesehen am 26.02.2024 | ||
| 520 | |a Background - Atrial fibrillation (AF) is a significant risk factor for cardiovascular (CV) mortality. This study aims to evaluate the prognostic implication of AF in patients with peripheral arterial disease (PAD). - Methods - The International Reduction of Atherothrombosis for Continued Health (REACH) Registry included 23,542 outpatients in Europe with established coronary artery disease, cerebrovascular disease (CVD), PAD and/or ≥3 risk factors. Of these, 3753 patients had symptomatic PAD. CV risk factors were determined at baseline. Study end point was a combination of cardiac death, non-fatal myocardial infarction (MI) and stroke (CV events) during 2 years of follow-up. Cox regression analysis adjusted for age, gender and other risk factors (i.e., congestive heart failure, coronary artery re-vascularisation, coronary artery bypass grafting (CABG), MI, hypertension, stroke, current smoking and diabetes) was used. - Results - Of 3753 PAD patients, 392 (10%) were known to have AF. Patients with AF were older and had a higher prevalence of CVD, diabetes and hypertension. Long-term CV mortality occurred in 5.6% of patients with AF and in 1.6% of those without AF (p<0.001). Multivariable analyses showed that AF was an independent predictor of late CV events (hazard ratio (HR): 1.5; 95% confidence interval (CI): 1.09-2.0). - Conclusion - AF is common in European patients with symptomatic PAD and is independently associated with a worse 2-year CV outcome. | ||
| 650 | 4 | |a Atrial fibrillation | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a REACH Registry | |
| 700 | 1 | |a Hoeks, S. E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schouten, O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zeymer, Uwe |e VerfasserIn |0 (DE-588)1163486884 |0 (DE-627)1027835694 |0 (DE-576)508027608 |4 aut | |
| 700 | 1 | |a Limbourg, Tobias |e VerfasserIn |0 (DE-588)1321748779 |0 (DE-627)1881627837 |4 aut | |
| 700 | 1 | |a Baumgartner, I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bhatt, D. L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steg, Ph. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goto, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Röther, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cacoub, P. P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Verhagen, H. J. M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bax, J. J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Poldermans, D. |e VerfasserIn |4 aut | |
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