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Efficient single copy integration via homology-directed repair (scHDR) by 5’modification of large DNA donor fragments in mice

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CRISPR/Cas approaches have largely replaced conventional gene targeting strategies. However, homology-directed repair (HDR) in the mouse genome is not very efficient, and precisely inserting longer sequences using HDR remains challenging, given that donor constructs preferentially integrate as conca...

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Main Authors: Medert, Rebekka (Author) , Thumberger, Thomas (Author) , Tavhelidse-Suck, Tinatini (Author) , Hub, Tobias (Author) , Kellner, Tanja (Author) , Oguchi, Yoko (Author) , Dlugosz, Sascha (Author) , Zimmermann, Frank (Author) , Wittbrodt, Joachim (Author) , Freichel, Marc (Author)
Format: Article (Journal) Chapter/Article
Language:English
Published: September 30, 2021
In: bioRxiv beta
Year: 2021, Pages: 1-37
DOI:10.1101/2021.09.30.462539
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1101/2021.09.30.462539
Verlag, lizenzpflichtig, Volltext: https://www.biorxiv.org/content/10.1101/2021.09.30.462539v1
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Author Notes:Rebekka Medert, Thomas Thumberger, Tinatini Tavhelidse, Tobias Hub, Tanja Kellner, Yoko Oguchi, Sascha Dlugosz, Frank Zimmermann, Joachim Wittbrodt, Marc Freichel
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Efficient single copy integration via homology-directed repair (scHDR) by 5′modification of large DNA donor fragments in mice by Medert, Rebekka (Author) , Thumberger, Thomas (Author) , Tavhelidse-Suck, Tinatini (Author) , Hub, Tobias (Author) , Kellner, Tanja (Author) , Oguchi, Yoko (Author) , Dlugosz, Sascha (Author) , Zimmermann, Frank (Author) , Wittbrodt, Joachim (Author) , Freichel, Marc (Author) ,


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