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Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

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Single nucleotide variants (SNVs) are prevalent genetic factors shaping individual trait profiles and disease susceptibility. The recent development and optimizations of base editors, rubber and pencil genome editing tools now promise to enable direct functional assessment of SNVs in model organisms...

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Main Authors: Cornean, Alex (Author) , Gierten, Jakob (Author) , Welz, Bettina (Author) , Mateo, Juan L. (Author) , Thumberger, Thomas (Author) , Wittbrodt, Joachim (Author)
Format: Article (Journal) Chapter/Article
Language:English
Published: July 26, 2021
In: bioRxiv beta
Year: 2021, Pages: 1-63
DOI:10.1101/2021.07.26.453883
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1101/2021.07.26.453883
Verlag, kostenfrei, Volltext: https://www.biorxiv.org/content/10.1101/2021.07.26.453883v1
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Author Notes:authors: Alex Cornean, Jakob Gierten, Bettina Welz, Juan L. Mateo, Thomas Thumberger, Joachim Wittbrodt
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Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction by Cornean, Alex (Author) , Gierten, Jakob (Author) , Welz, Bettina (Author) , Mateo, Juan L. (Author) , Thumberger, Thomas (Author) , Wittbrodt, Joachim (Author) ,


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