Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction
Single nucleotide variants (SNVs) are prevalent genetic factors shaping individual trait profiles and disease susceptibility. The recent development and optimizations of base editors, rubber and pencil genome editing tools now promise to enable direct functional assessment of SNVs in model organisms...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
July 26, 2021
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| In: |
bioRxiv beta
Year: 2021, Pages: 1-63 |
| DOI: | 10.1101/2021.07.26.453883 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1101/2021.07.26.453883 Verlag, kostenfrei, Volltext: https://www.biorxiv.org/content/10.1101/2021.07.26.453883v1 
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| Verfasserangaben: | authors: Alex Cornean, Jakob Gierten, Bettina Welz, Juan L. Mateo, Thomas Thumberger, Joachim Wittbrodt |
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