Buchumschlag

Microenvironmental signals shaping NK-cell reactivity in cancer: review

Since the postulation of the “missing-self” concept, much progress has been made in defining requirements for NK-cell activation. Unlike T lymphocytes that process signals from receptors in a hierarchic manner dominated by the T-cell receptors, NK cells integrate receptor signals more “democraticall...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Balzasch, Bianca M. (VerfasserIn) , Cerwenka, Adelheid (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 2023
In: European journal of immunology
Year: 2023, Jahrgang: 53, Heft: 12
ISSN:1521-4141
DOI:10.1002/eji.202250103
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/eji.202250103
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250103
Volltext
Verfasserangaben:Bianca M. Balzasch and Adelheid Cerwenka

MARC

LEADER 00000caa a2200000 c 4500
001 1881698823
003 DE-627
005 20240402140543.0
007 cr uuu---uuuuu
008 240227s2023 xx |||||o 00| ||eng c
024 7 |a 10.1002/eji.202250103  |2 doi 
035 |a (DE-627)1881698823 
035 |a (DE-599)KXP1881698823 
035 |a (OCoLC)1425200533 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Balzasch, Bianca M.  |d 1996-  |e VerfasserIn  |0 (DE-588)1321820755  |0 (DE-627)1881699811  |4 aut 
245 1 0 |a Microenvironmental signals shaping NK-cell reactivity in cancer  |b review  |c Bianca M. Balzasch and Adelheid Cerwenka 
264 1 |c December 2023 
300 |b Illustrationen 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online veröffentlicht: 17. Mai 2023 
500 |a Gesehen am 27.02.2024 
520 |a Since the postulation of the “missing-self” concept, much progress has been made in defining requirements for NK-cell activation. Unlike T lymphocytes that process signals from receptors in a hierarchic manner dominated by the T-cell receptors, NK cells integrate receptor signals more “democratically.” Signals originate not only the downstream of cell-surface receptors triggered by membrane-bound ligands or cytokines, but are also mediated by specialized microenvironmental sensors that perceive the cellular surrounding by detecting metabolites or the availability of oxygen. Thus, NK-cell effector functions are driven in an organ and disease-dependent manner. Here, we review the latest findings on how NK-cell reactivity in cancer is determined by the reception and integration of complex signals. Finally, we discuss how this knowledge can be exploited to guide novel combinatorial approaches for NK-cell-based anticancer therapies. 
650 4 |a Cancer 
650 4 |a Microenvironmental sensors 
650 4 |a NK cells 
650 4 |a NK-cell-based immunotherapy 
650 4 |a Tumor microenvironment 
700 1 |a Cerwenka, Adelheid  |d 1968-  |e VerfasserIn  |0 (DE-588)1076261019  |0 (DE-627)834583658  |0 (DE-576)271029749  |4 aut 
773 0 8 |i Enthalten in  |t European journal of immunology  |d Weinheim : Wiley-VCH, 1971  |g 53(2023), 12, Artikel-ID e2250103  |h Online-Ressource  |w (DE-627)302718842  |w (DE-600)1491907-2  |w (DE-576)079876684  |x 1521-4141  |7 nnas  |a Microenvironmental signals shaping NK-cell reactivity in cancer review 
773 1 8 |g volume:53  |g year:2023  |g number:12  |g elocationid:e2250103  |g extent:9  |a Microenvironmental signals shaping NK-cell reactivity in cancer review 
856 4 0 |u https://doi.org/10.1002/eji.202250103  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250103  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20240227 
993 |a Article 
994 |a 2023 
998 |g 1076261019  |a Cerwenka, Adelheid  |m 1076261019:Cerwenka, Adelheid  |d 60000  |d 65400  |e 60000PC1076261019  |e 65400PC1076261019  |k 0/60000/  |k 1/60000/65400/  |p 2  |y j 
998 |g 1321820755  |a Balzasch, Bianca M.  |m 1321820755:Balzasch, Bianca M.  |d 60000  |d 65400  |e 60000PB1321820755  |e 65400PB1321820755  |k 0/60000/  |k 1/60000/65400/  |p 1  |x j 
999 |a KXP-PPN1881698823  |e 4492001972 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"302718842","part":{"volume":"53","issue":"12","extent":"9","year":"2023","text":"53(2023), 12, Artikel-ID e2250103"},"disp":"Microenvironmental signals shaping NK-cell reactivity in cancer reviewEuropean journal of immunology","pubHistory":["1.1971 -"],"corporate":[{"display":"European Federation of Immunological Societies","role":"isb"}],"origin":[{"dateIssuedDisp":"1971-","dateIssuedKey":"1971","publisherPlace":"Weinheim","publisher":"Wiley-VCH"}],"id":{"eki":["302718842"],"zdb":["1491907-2"],"issn":["1521-4141"],"doi":["10.1002/(ISSN)1521-4141"]},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"European journal of immunology","title":"European journal of immunology","subtitle":"basic, clinical, translational"}],"note":["Gesehen am 28.09.2021","Fortsetzung der Druck-Ausgabe"]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","family":"Balzasch","display":"Balzasch, Bianca M.","given":"Bianca M."},{"given":"Adelheid","family":"Cerwenka","display":"Cerwenka, Adelheid","role":"aut"}],"recId":"1881698823","id":{"doi":["10.1002/eji.202250103"],"eki":["1881698823"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"December 2023"}],"name":{"displayForm":["Bianca M. Balzasch and Adelheid Cerwenka"]},"note":["Online veröffentlicht: 17. Mai 2023","Gesehen am 27.02.2024"],"language":["eng"],"title":[{"title_sort":"Microenvironmental signals shaping NK-cell reactivity in cancer","subtitle":"review","title":"Microenvironmental signals shaping NK-cell reactivity in cancer"}],"physDesc":[{"extent":"9 S.","noteIll":"Illustrationen"}]} 
SRT |a BALZASCHBIMICROENVIR2023 

Ähnliche Einträge