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Microenvironmental signals shaping NK-cell reactivity in cancer: review

Since the postulation of the “missing-self” concept, much progress has been made in defining requirements for NK-cell activation. Unlike T lymphocytes that process signals from receptors in a hierarchic manner dominated by the T-cell receptors, NK cells integrate receptor signals more “democraticall...

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Bibliographic Details
Main Authors: Balzasch, Bianca M. (Author) , Cerwenka, Adelheid (Author)
Format: Article (Journal)
Language:English
Published: December 2023
In: European journal of immunology
Year: 2023, Volume: 53, Issue: 12
ISSN:1521-4141
DOI:10.1002/eji.202250103
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/eji.202250103
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250103
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Author Notes:Bianca M. Balzasch and Adelheid Cerwenka

MARC

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520 |a Since the postulation of the “missing-self” concept, much progress has been made in defining requirements for NK-cell activation. Unlike T lymphocytes that process signals from receptors in a hierarchic manner dominated by the T-cell receptors, NK cells integrate receptor signals more “democratically.” Signals originate not only the downstream of cell-surface receptors triggered by membrane-bound ligands or cytokines, but are also mediated by specialized microenvironmental sensors that perceive the cellular surrounding by detecting metabolites or the availability of oxygen. Thus, NK-cell effector functions are driven in an organ and disease-dependent manner. Here, we review the latest findings on how NK-cell reactivity in cancer is determined by the reception and integration of complex signals. Finally, we discuss how this knowledge can be exploited to guide novel combinatorial approaches for NK-cell-based anticancer therapies. 
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